YopP-expressing variant of Y. pestis activates a potent innate immune response affording cross-protection against yersiniosis and tularemia [corrected].
Plague, initiated by Yersinia pestis infection, is a rapidly progressing disease with a high mortality rate if not quickly treated. The existence of antibiotic-resistant Y. pestis strains emphasizes the need for the development of novel countermeasures against plague. We previously reported the gene...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3865221?pdf=render |
| _version_ | 1819108028938452992 |
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| author | Ayelet Zauberman Yehuda Flashner Yinon Levy Yaron Vagima Avital Tidhar Ofer Cohen Erez Bar-Haim David Gur Moshe Aftalion Gideon Halperin Avigdor Shafferman Emanuelle Mamroud |
| author_facet | Ayelet Zauberman Yehuda Flashner Yinon Levy Yaron Vagima Avital Tidhar Ofer Cohen Erez Bar-Haim David Gur Moshe Aftalion Gideon Halperin Avigdor Shafferman Emanuelle Mamroud |
| author_sort | Ayelet Zauberman |
| collection | DOAJ |
| description | Plague, initiated by Yersinia pestis infection, is a rapidly progressing disease with a high mortality rate if not quickly treated. The existence of antibiotic-resistant Y. pestis strains emphasizes the need for the development of novel countermeasures against plague. We previously reported the generation of a recombinant Y. pestis strain (Kim53ΔJ+P) that over-expresses Y. enterocolitica YopP. When this strain was administered subcutaneously to mice, it elicited a fast and effective protective immune response in models of bubonic, pneumonic and septicemic plague. In the present study, we further characterized the immune response induced by the Kim53ΔJ+P recombinant strain. Using a panel of mouse strains defective in specific immune functions, we observed the induction of a prompt protective innate immune response that was interferon-γ dependent. Moreover, inoculation of mice with Y. pestis Kim53ΔJ+P elicited a rapid protective response against secondary infection by other bacterial pathogens, including the enteropathogen Y. enterocolitica and the respiratory pathogen Francisella tularensis. Thus, the development of new therapies to enhance the innate immune response may provide an initial critical delay in disease progression following the exposure to highly virulent bacterial pathogens, extending the time window for successful treatment. |
| first_indexed | 2024-12-22T03:03:25Z |
| format | Article |
| id | doaj.art-61b2332f79954324bc5c8bbf9fa91553 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T03:03:25Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-61b2332f79954324bc5c8bbf9fa915532022-12-21T18:41:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01812e8356010.1371/journal.pone.0083560YopP-expressing variant of Y. pestis activates a potent innate immune response affording cross-protection against yersiniosis and tularemia [corrected].Ayelet ZaubermanYehuda FlashnerYinon LevyYaron VagimaAvital TidharOfer CohenErez Bar-HaimDavid GurMoshe AftalionGideon HalperinAvigdor ShaffermanEmanuelle MamroudPlague, initiated by Yersinia pestis infection, is a rapidly progressing disease with a high mortality rate if not quickly treated. The existence of antibiotic-resistant Y. pestis strains emphasizes the need for the development of novel countermeasures against plague. We previously reported the generation of a recombinant Y. pestis strain (Kim53ΔJ+P) that over-expresses Y. enterocolitica YopP. When this strain was administered subcutaneously to mice, it elicited a fast and effective protective immune response in models of bubonic, pneumonic and septicemic plague. In the present study, we further characterized the immune response induced by the Kim53ΔJ+P recombinant strain. Using a panel of mouse strains defective in specific immune functions, we observed the induction of a prompt protective innate immune response that was interferon-γ dependent. Moreover, inoculation of mice with Y. pestis Kim53ΔJ+P elicited a rapid protective response against secondary infection by other bacterial pathogens, including the enteropathogen Y. enterocolitica and the respiratory pathogen Francisella tularensis. Thus, the development of new therapies to enhance the innate immune response may provide an initial critical delay in disease progression following the exposure to highly virulent bacterial pathogens, extending the time window for successful treatment.http://europepmc.org/articles/PMC3865221?pdf=render |
| spellingShingle | Ayelet Zauberman Yehuda Flashner Yinon Levy Yaron Vagima Avital Tidhar Ofer Cohen Erez Bar-Haim David Gur Moshe Aftalion Gideon Halperin Avigdor Shafferman Emanuelle Mamroud YopP-expressing variant of Y. pestis activates a potent innate immune response affording cross-protection against yersiniosis and tularemia [corrected]. PLoS ONE |
| title | YopP-expressing variant of Y. pestis activates a potent innate immune response affording cross-protection against yersiniosis and tularemia [corrected]. |
| title_full | YopP-expressing variant of Y. pestis activates a potent innate immune response affording cross-protection against yersiniosis and tularemia [corrected]. |
| title_fullStr | YopP-expressing variant of Y. pestis activates a potent innate immune response affording cross-protection against yersiniosis and tularemia [corrected]. |
| title_full_unstemmed | YopP-expressing variant of Y. pestis activates a potent innate immune response affording cross-protection against yersiniosis and tularemia [corrected]. |
| title_short | YopP-expressing variant of Y. pestis activates a potent innate immune response affording cross-protection against yersiniosis and tularemia [corrected]. |
| title_sort | yopp expressing variant of y pestis activates a potent innate immune response affording cross protection against yersiniosis and tularemia corrected |
| url | http://europepmc.org/articles/PMC3865221?pdf=render |
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