Early and Late Postoperative Seizures in Meningioma Patients and Prediction by a Recent Scoring System
Seizures are among the most common symptoms of meningioma. This retrospective study sought to identify risk factors for early and late seizures in meningioma patients and to evaluate a modified STAMPE2 score. In 556 patients who underwent meningioma surgery, we correlated different risk factors with...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/3/450 |
| _version_ | 1797407566584610816 |
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| author | Peter Baumgarten Mana Sarlak Daniel Monden Andrea Spyrantis Simon Bernatz Florian Gessler Daniel Dubinski Elke Hattingen Gerhard Marquardt Adam Strzelczyk Felix Rosenow Patrick N. Harter Volker Seifert Thomas M. Freiman |
| author_facet | Peter Baumgarten Mana Sarlak Daniel Monden Andrea Spyrantis Simon Bernatz Florian Gessler Daniel Dubinski Elke Hattingen Gerhard Marquardt Adam Strzelczyk Felix Rosenow Patrick N. Harter Volker Seifert Thomas M. Freiman |
| author_sort | Peter Baumgarten |
| collection | DOAJ |
| description | Seizures are among the most common symptoms of meningioma. This retrospective study sought to identify risk factors for early and late seizures in meningioma patients and to evaluate a modified STAMPE2 score. In 556 patients who underwent meningioma surgery, we correlated different risk factors with the occurrence of postoperative seizures. A modified STAMPE2 score was applied. Risk factors for preoperative seizures were edema (<i>p</i> = 0.039) and temporal location (<i>p</i> = 0.038). For postoperative seizures preoperative tumor size (<i>p</i> < 0.001), sensomotory deficit (<i>p</i> = 0.004) and sphenoid wing location (<i>p</i> = 0.032) were independent risk factors. In terms of postoperative status epilepticus; sphenoid wing location (<i>p</i> = 0.022), tumor volume (<i>p</i> = 0.045) and preoperative seizures (<i>p</i> < 0.001) were independent risk factors. Postoperative seizures lead to a KPS deterioration and thus an impaired quality of life (<i>p</i> < 0.001). Late seizures occurred in 43% of patients with postoperative seizures. The small sub-cohort of patients (2.7%) with a STAMPE2 score of more than six points had a significantly increased risk for seizures (<i>p</i> < 0.001, total risk 70%). We concluded that besides distinct risk factors, high scores of the modified STAMPE2 score could estimate the risk of postoperative seizures. However, it seems not transferable to our cohort |
| first_indexed | 2024-03-09T03:43:25Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T03:43:25Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-61b2350313cd47da92b0b695ffc0d4652023-12-03T14:36:42ZengMDPI AGCancers2072-66942021-01-0113345010.3390/cancers13030450Early and Late Postoperative Seizures in Meningioma Patients and Prediction by a Recent Scoring SystemPeter Baumgarten0Mana Sarlak1Daniel Monden2Andrea Spyrantis3Simon Bernatz4Florian Gessler5Daniel Dubinski6Elke Hattingen7Gerhard Marquardt8Adam Strzelczyk9Felix Rosenow10Patrick N. Harter11Volker Seifert12Thomas M. Freiman13Department of Neurosurgery, University Hospital, Goethe University Frankfurt, 60528 Frankfurt am Main, GermanyDepartment of Neurosurgery, University Hospital, Goethe University Frankfurt, 60528 Frankfurt am Main, GermanyDepartment of Neurosurgery, University Hospital, Goethe University Frankfurt, 60528 Frankfurt am Main, GermanyDepartment of Neurosurgery, University Hospital, Goethe University Frankfurt, 60528 Frankfurt am Main, GermanyNeurological Institute (Edinger Institute), University Hospital, Goethe University Frankfurt, 60528 Frankfurt am Main, GermanyDepartment of Neurosurgery, University Hospital, Goethe University Frankfurt, 60528 Frankfurt am Main, GermanyDepartment of Neurosurgery, University Hospital, Goethe University Frankfurt, 60528 Frankfurt am Main, GermanyDepartment of Neuroradiology, University Hospital, Goethe University Frankfurt, 60528 Frankfurt am Main, GermanyDepartment of Neurosurgery, University Hospital, Goethe University Frankfurt, 60528 Frankfurt am Main, GermanyEpilepsy Center Frankfurt Rhine-Main, University Hospital, Goethe University Frankfurt, 60528 Frankfurt am Main, GermanyEpilepsy Center Frankfurt Rhine-Main, University Hospital, Goethe University Frankfurt, 60528 Frankfurt am Main, GermanyNeurological Institute (Edinger Institute), University Hospital, Goethe University Frankfurt, 60528 Frankfurt am Main, GermanyDepartment of Neurosurgery, University Hospital, Goethe University Frankfurt, 60528 Frankfurt am Main, GermanyDepartment of Neurosurgery, University Hospital, Goethe University Frankfurt, 60528 Frankfurt am Main, GermanySeizures are among the most common symptoms of meningioma. This retrospective study sought to identify risk factors for early and late seizures in meningioma patients and to evaluate a modified STAMPE2 score. In 556 patients who underwent meningioma surgery, we correlated different risk factors with the occurrence of postoperative seizures. A modified STAMPE2 score was applied. Risk factors for preoperative seizures were edema (<i>p</i> = 0.039) and temporal location (<i>p</i> = 0.038). For postoperative seizures preoperative tumor size (<i>p</i> < 0.001), sensomotory deficit (<i>p</i> = 0.004) and sphenoid wing location (<i>p</i> = 0.032) were independent risk factors. In terms of postoperative status epilepticus; sphenoid wing location (<i>p</i> = 0.022), tumor volume (<i>p</i> = 0.045) and preoperative seizures (<i>p</i> < 0.001) were independent risk factors. Postoperative seizures lead to a KPS deterioration and thus an impaired quality of life (<i>p</i> < 0.001). Late seizures occurred in 43% of patients with postoperative seizures. The small sub-cohort of patients (2.7%) with a STAMPE2 score of more than six points had a significantly increased risk for seizures (<i>p</i> < 0.001, total risk 70%). We concluded that besides distinct risk factors, high scores of the modified STAMPE2 score could estimate the risk of postoperative seizures. However, it seems not transferable to our cohorthttps://www.mdpi.com/2072-6694/13/3/450anticonvulsantsepilepsymeningiomaseizuresSTAMPE2 |
| spellingShingle | Peter Baumgarten Mana Sarlak Daniel Monden Andrea Spyrantis Simon Bernatz Florian Gessler Daniel Dubinski Elke Hattingen Gerhard Marquardt Adam Strzelczyk Felix Rosenow Patrick N. Harter Volker Seifert Thomas M. Freiman Early and Late Postoperative Seizures in Meningioma Patients and Prediction by a Recent Scoring System Cancers anticonvulsants epilepsy meningioma seizures STAMPE2 |
| title | Early and Late Postoperative Seizures in Meningioma Patients and Prediction by a Recent Scoring System |
| title_full | Early and Late Postoperative Seizures in Meningioma Patients and Prediction by a Recent Scoring System |
| title_fullStr | Early and Late Postoperative Seizures in Meningioma Patients and Prediction by a Recent Scoring System |
| title_full_unstemmed | Early and Late Postoperative Seizures in Meningioma Patients and Prediction by a Recent Scoring System |
| title_short | Early and Late Postoperative Seizures in Meningioma Patients and Prediction by a Recent Scoring System |
| title_sort | early and late postoperative seizures in meningioma patients and prediction by a recent scoring system |
| topic | anticonvulsants epilepsy meningioma seizures STAMPE2 |
| url | https://www.mdpi.com/2072-6694/13/3/450 |
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