Preoperative ejection fraction as a predictor of survival after coronary artery bypass grafting: comparison with a matched general population
<p>Abstract</p> <p>Background</p> <p>Preoperative left ventricular dysfunction is an established risk factor for early and late mortality after revascularization. This retrospective analysis demonstrates the effects of preoperative ejection fraction on the short-term an...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-04-01
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| Series: | Journal of Cardiothoracic Surgery |
| Online Access: | http://www.cardiothoracicsurgery.org/content/5/1/29 |
| _version_ | 1818472663157309440 |
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| author | Martens Elisabeth J de Wolf Andre M ter Woorst Joost F Schönberger Jacques PAM van Straten Albert HM Soliman Hamad Mohamed van Zundert André AJ |
| author_facet | Martens Elisabeth J de Wolf Andre M ter Woorst Joost F Schönberger Jacques PAM van Straten Albert HM Soliman Hamad Mohamed van Zundert André AJ |
| author_sort | Martens Elisabeth J |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Preoperative left ventricular dysfunction is an established risk factor for early and late mortality after revascularization. This retrospective analysis demonstrates the effects of preoperative ejection fraction on the short-term and long-term survival of patients after coronary artery bypass grafting.</p> <p>Methods</p> <p>Early and late mortality were determined retrospectively in 10 626 consecutive patients who underwent isolated coronary bypass between January 1998 and December 2007. The subjects were divided into 3 groups according to their preoperative ejection fraction. Expected survival was estimated by comparison with a general Dutch population group described in the database of the Dutch Central Bureau for Statistics. For each of our groups with a known preoperative ejection fraction, a general Dutch population group was matched for age, sex, and year of operation.</p> <p>Results and Discussion</p> <p>One hundred twenty-two patients were lost to follow-up. In 219 patients, the preoperative ejection fraction could not be retrieved. In the remaining patients (n = 10 285), the results of multivariate logistic regression and Cox regression analysis identified the ejection fraction as a predictor of early and late mortality. When we compared long-term survival and expected survival, we found a relatively poorer outcome in all subjects with an ejection fraction of < 50%. In subjects with a preoperative ejection fraction of > 50%, long-term survival exceeded expected survival.</p> <p>Conclusions</p> <p>The severity of left ventricular dysfunction was associated with poor survival. Compared with the survival of the matched general population, our coronary bypass patients had a worse outcome only if their preoperative ejection fraction was < 50%.</p> |
| first_indexed | 2024-04-14T04:10:37Z |
| format | Article |
| id | doaj.art-61b2399bd8a141a9b1a90ba4b1ffbb3b |
| institution | Directory Open Access Journal |
| issn | 1749-8090 |
| language | English |
| last_indexed | 2024-04-14T04:10:37Z |
| publishDate | 2010-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj.art-61b2399bd8a141a9b1a90ba4b1ffbb3b2022-12-22T02:13:10ZengBMCJournal of Cardiothoracic Surgery1749-80902010-04-01512910.1186/1749-8090-5-29Preoperative ejection fraction as a predictor of survival after coronary artery bypass grafting: comparison with a matched general populationMartens Elisabeth Jde Wolf Andre Mter Woorst Joost FSchönberger Jacques PAMvan Straten Albert HMSoliman Hamad Mohamedvan Zundert André AJ<p>Abstract</p> <p>Background</p> <p>Preoperative left ventricular dysfunction is an established risk factor for early and late mortality after revascularization. This retrospective analysis demonstrates the effects of preoperative ejection fraction on the short-term and long-term survival of patients after coronary artery bypass grafting.</p> <p>Methods</p> <p>Early and late mortality were determined retrospectively in 10 626 consecutive patients who underwent isolated coronary bypass between January 1998 and December 2007. The subjects were divided into 3 groups according to their preoperative ejection fraction. Expected survival was estimated by comparison with a general Dutch population group described in the database of the Dutch Central Bureau for Statistics. For each of our groups with a known preoperative ejection fraction, a general Dutch population group was matched for age, sex, and year of operation.</p> <p>Results and Discussion</p> <p>One hundred twenty-two patients were lost to follow-up. In 219 patients, the preoperative ejection fraction could not be retrieved. In the remaining patients (n = 10 285), the results of multivariate logistic regression and Cox regression analysis identified the ejection fraction as a predictor of early and late mortality. When we compared long-term survival and expected survival, we found a relatively poorer outcome in all subjects with an ejection fraction of < 50%. In subjects with a preoperative ejection fraction of > 50%, long-term survival exceeded expected survival.</p> <p>Conclusions</p> <p>The severity of left ventricular dysfunction was associated with poor survival. Compared with the survival of the matched general population, our coronary bypass patients had a worse outcome only if their preoperative ejection fraction was < 50%.</p>http://www.cardiothoracicsurgery.org/content/5/1/29 |
| spellingShingle | Martens Elisabeth J de Wolf Andre M ter Woorst Joost F Schönberger Jacques PAM van Straten Albert HM Soliman Hamad Mohamed van Zundert André AJ Preoperative ejection fraction as a predictor of survival after coronary artery bypass grafting: comparison with a matched general population Journal of Cardiothoracic Surgery |
| title | Preoperative ejection fraction as a predictor of survival after coronary artery bypass grafting: comparison with a matched general population |
| title_full | Preoperative ejection fraction as a predictor of survival after coronary artery bypass grafting: comparison with a matched general population |
| title_fullStr | Preoperative ejection fraction as a predictor of survival after coronary artery bypass grafting: comparison with a matched general population |
| title_full_unstemmed | Preoperative ejection fraction as a predictor of survival after coronary artery bypass grafting: comparison with a matched general population |
| title_short | Preoperative ejection fraction as a predictor of survival after coronary artery bypass grafting: comparison with a matched general population |
| title_sort | preoperative ejection fraction as a predictor of survival after coronary artery bypass grafting comparison with a matched general population |
| url | http://www.cardiothoracicsurgery.org/content/5/1/29 |
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