Successful recovery from severe hypertension in a patient with Leigh syndrome
Hypertension is a rare complication of Leigh Syndrome (LS), but prognosis of patients with hypertension is poor and its presence is indicative of the terminal stage of the disease. Herein, we report a four-year-old girl case diagnosed with LS at 15 months of age who subsequently developed severe hyp...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Molecular Genetics and Metabolism Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214426920301300 |
| _version_ | 1818594500706041856 |
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| author | Yuto Arai Kiyotaka Kosugiyama Takuya Tamura Sasagu Matsumoto Akira Sudo Hideaki Shiraishi Cammack Ivor Akira Ohtake Kiyoshi Nagumo |
| author_facet | Yuto Arai Kiyotaka Kosugiyama Takuya Tamura Sasagu Matsumoto Akira Sudo Hideaki Shiraishi Cammack Ivor Akira Ohtake Kiyoshi Nagumo |
| author_sort | Yuto Arai |
| collection | DOAJ |
| description | Hypertension is a rare complication of Leigh Syndrome (LS), but prognosis of patients with hypertension is poor and its presence is indicative of the terminal stage of the disease. Herein, we report a four-year-old girl case diagnosed with LS at 15 months of age who subsequently developed severe hypertension and respiratory failure. Physical examination and laboratory findings did not indicate a secondary cause of hypertension. Her respiratory failure was treated with non-invasive ventilation and hypertension controlled with enalapril, furosemide and spironolactone. To our knowledge, this is the first case of a patient with LS recovering from severe hypertension. |
| first_indexed | 2024-12-16T11:01:07Z |
| format | Article |
| id | doaj.art-61b2938a30e34a0e824097d2332f01ef |
| institution | Directory Open Access Journal |
| issn | 2214-4269 |
| language | English |
| last_indexed | 2024-12-16T11:01:07Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Genetics and Metabolism Reports |
| spelling | doaj.art-61b2938a30e34a0e824097d2332f01ef2022-12-21T22:33:59ZengElsevierMolecular Genetics and Metabolism Reports2214-42692020-12-0125100684Successful recovery from severe hypertension in a patient with Leigh syndromeYuto Arai0Kiyotaka Kosugiyama1Takuya Tamura2Sasagu Matsumoto3Akira Sudo4Hideaki Shiraishi5Cammack Ivor6Akira Ohtake7Kiyoshi Nagumo8Department of Pediatrics, Teine-Keijinkai Hospital, Sapporo, Japan; Corresponding author.Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, JapanDepartment of Pediatrics, Teine-Keijinkai Hospital, Sapporo, JapanDepartment of Pediatrics, Teine-Keijinkai Hospital, Sapporo, JapanSocial Welfare Corporation Nire-no-kai Children's Clinic, Sapporo, JapanDepartment of Pediatrics, Hokkaido University School of Medicine, Sapporo, JapanDepartment of Clinical Residency Training, Teine-Keijinkai Hospital, Sapporo, JapanCenter for Intractable Diseases, Saitama Medical University Hospital, Saitama, JapanDepartment of Pediatrics, Teine-Keijinkai Hospital, Sapporo, JapanHypertension is a rare complication of Leigh Syndrome (LS), but prognosis of patients with hypertension is poor and its presence is indicative of the terminal stage of the disease. Herein, we report a four-year-old girl case diagnosed with LS at 15 months of age who subsequently developed severe hypertension and respiratory failure. Physical examination and laboratory findings did not indicate a secondary cause of hypertension. Her respiratory failure was treated with non-invasive ventilation and hypertension controlled with enalapril, furosemide and spironolactone. To our knowledge, this is the first case of a patient with LS recovering from severe hypertension.http://www.sciencedirect.com/science/article/pii/S2214426920301300Leigh syndromeHypertensionRespiratory failureMedulla oblongataNucleus tractus solitarii |
| spellingShingle | Yuto Arai Kiyotaka Kosugiyama Takuya Tamura Sasagu Matsumoto Akira Sudo Hideaki Shiraishi Cammack Ivor Akira Ohtake Kiyoshi Nagumo Successful recovery from severe hypertension in a patient with Leigh syndrome Molecular Genetics and Metabolism Reports Leigh syndrome Hypertension Respiratory failure Medulla oblongata Nucleus tractus solitarii |
| title | Successful recovery from severe hypertension in a patient with Leigh syndrome |
| title_full | Successful recovery from severe hypertension in a patient with Leigh syndrome |
| title_fullStr | Successful recovery from severe hypertension in a patient with Leigh syndrome |
| title_full_unstemmed | Successful recovery from severe hypertension in a patient with Leigh syndrome |
| title_short | Successful recovery from severe hypertension in a patient with Leigh syndrome |
| title_sort | successful recovery from severe hypertension in a patient with leigh syndrome |
| topic | Leigh syndrome Hypertension Respiratory failure Medulla oblongata Nucleus tractus solitarii |
| url | http://www.sciencedirect.com/science/article/pii/S2214426920301300 |
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