Mast cells in central nervous system neoplasms: an immunohistochemical study
Objective: To investigate the relationship between mast cells (MCs) and different central nervous system (CNS) tumors. Methods: It was a comparative immunohistochemical study to investigate the presence, number, and location of MCs in pilocytic astrocytomas, glioblastoma, medulloblastoma, ependymoma...
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Permanyer
2023-10-01
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| Series: | Revista Mexicana de Neurociencia |
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| Online Access: | https://www.revmexneurociencia.com/frame_esp.php?id=223 |
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| author | Aldair Ochoa-Rojas Ana L. Calderón-Garcidueñas César I. Peña-Ruelas Rubén Ruiz-Ramos Noé López-Amador Enrique Villarreal-Ríos Edmundo E. Castelán-Maldonado |
| author_facet | Aldair Ochoa-Rojas Ana L. Calderón-Garcidueñas César I. Peña-Ruelas Rubén Ruiz-Ramos Noé López-Amador Enrique Villarreal-Ríos Edmundo E. Castelán-Maldonado |
| author_sort | Aldair Ochoa-Rojas |
| collection | DOAJ |
| description | Objective: To investigate the relationship between mast cells (MCs) and different central nervous system (CNS) tumors. Methods: It was a comparative immunohistochemical study to investigate the presence, number, and location of MCs in pilocytic astrocytomas, glioblastoma, medulloblastoma, ependymoma, meningioma, and immature and mature teratomas. Means, medians, and standard deviation were obtained. Comparation in the number of MCs in the different tumors was carried out using the Mann–Whitney test (p < 0.05). Results: There was a significant difference in the number of MCs between pilocytic astrocytoma (X? = 0), and mature teratoma (X? = 65), in relation to the other neoplasms (X? = 3-11.4). MCs were identified in meningeal lining in meningiomas, in the perivascular space in ependymomas and in the tumor stroma and perivascular space in the rest of the tumors analyzed. Conclusions: MCs appear to play different roles in CNS tumors. Its absence in pilocytic astrocytomas and its presence in glioblastomas suggests a role in the latter, probably related to angiogenesis. The maximum number of MCs was observed in mature teratomas, specifically in relation to stratified squamous epithelium, possibly in relation to trophic factors that contribute to epithelial renewal and maintenance. These findings call for future research to determine if MCs can be a therapeutic target or are important as a prognostic factor.
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| first_indexed | 2024-03-12T21:29:33Z |
| format | Article |
| id | doaj.art-61b2bf21d0364ad391d3814b5ab06914 |
| institution | Directory Open Access Journal |
| issn | 2604-6180 |
| language | English |
| last_indexed | 2024-03-12T21:29:33Z |
| publishDate | 2023-10-01 |
| publisher | Permanyer |
| record_format | Article |
| series | Revista Mexicana de Neurociencia |
| spelling | doaj.art-61b2bf21d0364ad391d3814b5ab069142023-07-27T22:40:01ZengPermanyerRevista Mexicana de Neurociencia2604-61802023-10-0124410.24875/RMN.22000085Mast cells in central nervous system neoplasms: an immunohistochemical studyAldair Ochoa-Rojas0Ana L. Calderón-Garcidueñas1César I. Peña-Ruelas2Rubén Ruiz-Ramos3Noé López-Amador4Enrique Villarreal-Ríos5Edmundo E. Castelán-Maldonado6Faculty of Bioanalysis, Universidad Veracruzana, Veracruz, MéxicoNeuropathology Department, Instituto Nacional de Neurología y Neurocirugia, Ciudad de México, MéxicoPathology Department, Unidad Médica de Alta Especialidad, Monterrey, Nuevo León, MéxicoFaculty of Medicine, Universidad Veracruzana, Veracruz, MéxicoInstituto de Medicina Forense, Universidad Veracruzana, Veracruz, MéxicoUnidad Regional de Investigación Epidemiológica en Servicios de Salud Querétaro, Querétaro, MéxicoPathology Department, Unidad Médica de Alta Especialidad, Monterrey, Nuevo León, MéxicoObjective: To investigate the relationship between mast cells (MCs) and different central nervous system (CNS) tumors. Methods: It was a comparative immunohistochemical study to investigate the presence, number, and location of MCs in pilocytic astrocytomas, glioblastoma, medulloblastoma, ependymoma, meningioma, and immature and mature teratomas. Means, medians, and standard deviation were obtained. Comparation in the number of MCs in the different tumors was carried out using the Mann–Whitney test (p < 0.05). Results: There was a significant difference in the number of MCs between pilocytic astrocytoma (X? = 0), and mature teratoma (X? = 65), in relation to the other neoplasms (X? = 3-11.4). MCs were identified in meningeal lining in meningiomas, in the perivascular space in ependymomas and in the tumor stroma and perivascular space in the rest of the tumors analyzed. Conclusions: MCs appear to play different roles in CNS tumors. Its absence in pilocytic astrocytomas and its presence in glioblastomas suggests a role in the latter, probably related to angiogenesis. The maximum number of MCs was observed in mature teratomas, specifically in relation to stratified squamous epithelium, possibly in relation to trophic factors that contribute to epithelial renewal and maintenance. These findings call for future research to determine if MCs can be a therapeutic target or are important as a prognostic factor. https://www.revmexneurociencia.com/frame_esp.php?id=223Mast cells. Brain tumors. Glioblastoma. Teratoma. Meningioma. |
| spellingShingle | Aldair Ochoa-Rojas Ana L. Calderón-Garcidueñas César I. Peña-Ruelas Rubén Ruiz-Ramos Noé López-Amador Enrique Villarreal-Ríos Edmundo E. Castelán-Maldonado Mast cells in central nervous system neoplasms: an immunohistochemical study Revista Mexicana de Neurociencia Mast cells. Brain tumors. Glioblastoma. Teratoma. Meningioma. |
| title | Mast cells in central nervous system neoplasms: an immunohistochemical study |
| title_full | Mast cells in central nervous system neoplasms: an immunohistochemical study |
| title_fullStr | Mast cells in central nervous system neoplasms: an immunohistochemical study |
| title_full_unstemmed | Mast cells in central nervous system neoplasms: an immunohistochemical study |
| title_short | Mast cells in central nervous system neoplasms: an immunohistochemical study |
| title_sort | mast cells in central nervous system neoplasms an immunohistochemical study |
| topic | Mast cells. Brain tumors. Glioblastoma. Teratoma. Meningioma. |
| url | https://www.revmexneurociencia.com/frame_esp.php?id=223 |
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