Astroglia in Autism Spectrum Disorder
Autism spectrum disorder (ASD) is an umbrella term encompassing several neurodevelopmental disorders such as Asperger syndrome or autism. It is characterised by the occurrence of distinct deficits in social behaviour and communication and repetitive patterns of behaviour. The symptoms may be of diff...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-10-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/21/11544 |
| _version_ | 1797512424736161792 |
|---|---|
| author | Kinga Gzielo Agnieszka Nikiforuk |
| author_facet | Kinga Gzielo Agnieszka Nikiforuk |
| author_sort | Kinga Gzielo |
| collection | DOAJ |
| description | Autism spectrum disorder (ASD) is an umbrella term encompassing several neurodevelopmental disorders such as Asperger syndrome or autism. It is characterised by the occurrence of distinct deficits in social behaviour and communication and repetitive patterns of behaviour. The symptoms may be of different intensity and may vary in types. Risk factors for ASD include disturbed brain homeostasis, genetic predispositions, or inflammation during the prenatal period caused by viruses or bacteria. The number of diagnosed cases is growing, but the main cause and mechanism leading to ASD is still uncertain. Recent findings from animal models and human cases highlight the contribution of glia to the ASD pathophysiology. It is known that glia cells are not only “gluing” neurons together but are key players participating in different processes crucial for proper brain functioning, including neurogenesis, synaptogenesis, inflammation, myelination, proper glutamate processing and many others. Despite the prerequisites for the involvement of glia in the processes related to the onset of autism, there are far too little data regarding the engagement of these cells in the development of ASD. |
| first_indexed | 2024-03-10T06:01:38Z |
| format | Article |
| id | doaj.art-61b3b4142b95473fb72b52b3ce9f4aaa |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:01:38Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-61b3b4142b95473fb72b52b3ce9f4aaa2023-11-22T20:53:56ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-10-0122211154410.3390/ijms222111544Astroglia in Autism Spectrum DisorderKinga Gzielo0Agnieszka Nikiforuk1Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Behavioral Neuroscience and Drug Development, 12 Smętna Street, 31-343 Kraków, PolandMaj Institute of Pharmacology, Polish Academy of Sciences, Department of Behavioral Neuroscience and Drug Development, 12 Smętna Street, 31-343 Kraków, PolandAutism spectrum disorder (ASD) is an umbrella term encompassing several neurodevelopmental disorders such as Asperger syndrome or autism. It is characterised by the occurrence of distinct deficits in social behaviour and communication and repetitive patterns of behaviour. The symptoms may be of different intensity and may vary in types. Risk factors for ASD include disturbed brain homeostasis, genetic predispositions, or inflammation during the prenatal period caused by viruses or bacteria. The number of diagnosed cases is growing, but the main cause and mechanism leading to ASD is still uncertain. Recent findings from animal models and human cases highlight the contribution of glia to the ASD pathophysiology. It is known that glia cells are not only “gluing” neurons together but are key players participating in different processes crucial for proper brain functioning, including neurogenesis, synaptogenesis, inflammation, myelination, proper glutamate processing and many others. Despite the prerequisites for the involvement of glia in the processes related to the onset of autism, there are far too little data regarding the engagement of these cells in the development of ASD.https://www.mdpi.com/1422-0067/22/21/11544autismastrocytesglia |
| spellingShingle | Kinga Gzielo Agnieszka Nikiforuk Astroglia in Autism Spectrum Disorder International Journal of Molecular Sciences autism astrocytes glia |
| title | Astroglia in Autism Spectrum Disorder |
| title_full | Astroglia in Autism Spectrum Disorder |
| title_fullStr | Astroglia in Autism Spectrum Disorder |
| title_full_unstemmed | Astroglia in Autism Spectrum Disorder |
| title_short | Astroglia in Autism Spectrum Disorder |
| title_sort | astroglia in autism spectrum disorder |
| topic | autism astrocytes glia |
| url | https://www.mdpi.com/1422-0067/22/21/11544 |
| work_keys_str_mv | AT kingagzielo astrogliainautismspectrumdisorder AT agnieszkanikiforuk astrogliainautismspectrumdisorder |