Lactate Is a Metabolic Mediator That Shapes Immune Cell Fate and Function

Lactate Is a Metabolic Mediator That Shapes Immune Cell Fate and Function

Lactate and the associated H+ ions are still introduced in many biochemistry and general biology textbooks and courses as a metabolic by-product within fast or oxygen-independent glycolysis. However, the role of lactate as a fuel source has been well-appreciated in the field of physiology, and the r...

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Bibliographic Details
Main Authors: Heather L. Caslin, Daniel Abebayehu, Julia A. Pinette, John J. Ryan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Physiology
Subjects:
lactic acid
lactate
immunosuppression
Th17
immunometabolism
M2
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.688485/full

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