Evaluation of the Effect of Platelet Rich Fibrin Matrix in the Correction of Periorbital Wrinkles: An Experimental Clinical Trial
Introduction: Skin rejuvenation techniques have gained substantial popularity due to increased life expectancy over recent years. Platelet-rich fibrin matrix (PRFM) is the new generation of platelet aggregate products that have surfaced in recent years to treat skin aging. Objectives: We intend t...
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| Format: | Article |
| Language: | English |
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Mattioli1885
2023-01-01
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| Series: | Dermatology Practical & Conceptual |
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| Online Access: | https://dpcj.org/index.php/dpc/article/view/2535 |
| _version_ | 1811172120010424320 |
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| author | Razieh Ahmadi Mahmoodabadi Habib Allah Golafshan Fatemehsadat Pezeshkian Reza Shahriarirad Mohammad Reza Namazi |
| author_facet | Razieh Ahmadi Mahmoodabadi Habib Allah Golafshan Fatemehsadat Pezeshkian Reza Shahriarirad Mohammad Reza Namazi |
| author_sort | Razieh Ahmadi Mahmoodabadi |
| collection | DOAJ |
| description |
Introduction: Skin rejuvenation techniques have gained substantial popularity due to increased life expectancy over recent years. Platelet-rich fibrin matrix (PRFM) is the new generation of platelet aggregate products that have surfaced in recent years to treat skin aging.
Objectives: We intend to use PRF to correct periorbital wrinkles in 15 volunteers and evaluate its effectiveness in this study.
Methods: To evaluate the efficacy of PRFM intervention, eight men and women over the age of thirty entered our study. Blood samples were taken and were immediately centrifuged at 700rpm for 5 minutes. PRFM was extracted from the plasma and was injected at the sub-dermis site in periorbital areas. The initial severity of periorbital wrinkles was determined by Visioface 1000D, and obtained numbers were delivered to the statistical unit for statistical analysis. Scoring and evaluation were based on tissue volume and depth and were measured before and twelve weeks after injection. Adverse effects were also taken into consideration.
Results: The results demonstrated noticeable improvement in deep, fine, and small wrinkles, periocular hyperpigmentation, and overall skin freshness of the injection site. The subjects had swelling in the injection site for up to one day after the injection, which resolved without complications.
Conclusions: PRFM was observed to have potential in skin rejuvenation, demonstrating promising outcomes in terms of safety and long-term effects in improving skin condition.
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| first_indexed | 2024-04-10T17:25:53Z |
| format | Article |
| id | doaj.art-61b42abf2aac4355a3fcda0819c217f2 |
| institution | Directory Open Access Journal |
| issn | 2160-9381 |
| language | English |
| last_indexed | 2024-04-10T17:25:53Z |
| publishDate | 2023-01-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Dermatology Practical & Conceptual |
| spelling | doaj.art-61b42abf2aac4355a3fcda0819c217f22023-02-04T11:17:25ZengMattioli1885Dermatology Practical & Conceptual2160-93812023-01-0113110.5826/dpc.1301a50Evaluation of the Effect of Platelet Rich Fibrin Matrix in the Correction of Periorbital Wrinkles: An Experimental Clinical TrialRazieh Ahmadi Mahmoodabadi0Habib Allah Golafshan1Fatemehsadat Pezeshkian2Reza Shahriarirad3Mohammad Reza Namazi4Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, IranShiraz Paramedical School, Shiraz University of Medical Sciences, Shiraz, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranSchool of Medicine, Shiraz University of Medical Sciences, Shiraz, IranMolecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Introduction: Skin rejuvenation techniques have gained substantial popularity due to increased life expectancy over recent years. Platelet-rich fibrin matrix (PRFM) is the new generation of platelet aggregate products that have surfaced in recent years to treat skin aging. Objectives: We intend to use PRF to correct periorbital wrinkles in 15 volunteers and evaluate its effectiveness in this study. Methods: To evaluate the efficacy of PRFM intervention, eight men and women over the age of thirty entered our study. Blood samples were taken and were immediately centrifuged at 700rpm for 5 minutes. PRFM was extracted from the plasma and was injected at the sub-dermis site in periorbital areas. The initial severity of periorbital wrinkles was determined by Visioface 1000D, and obtained numbers were delivered to the statistical unit for statistical analysis. Scoring and evaluation were based on tissue volume and depth and were measured before and twelve weeks after injection. Adverse effects were also taken into consideration. Results: The results demonstrated noticeable improvement in deep, fine, and small wrinkles, periocular hyperpigmentation, and overall skin freshness of the injection site. The subjects had swelling in the injection site for up to one day after the injection, which resolved without complications. Conclusions: PRFM was observed to have potential in skin rejuvenation, demonstrating promising outcomes in terms of safety and long-term effects in improving skin condition. https://dpcj.org/index.php/dpc/article/view/2535Platelet-rich fibrin matrixSkinCosmetics |
| spellingShingle | Razieh Ahmadi Mahmoodabadi Habib Allah Golafshan Fatemehsadat Pezeshkian Reza Shahriarirad Mohammad Reza Namazi Evaluation of the Effect of Platelet Rich Fibrin Matrix in the Correction of Periorbital Wrinkles: An Experimental Clinical Trial Dermatology Practical & Conceptual Platelet-rich fibrin matrix Skin Cosmetics |
| title | Evaluation of the Effect of Platelet Rich Fibrin Matrix in the Correction of Periorbital Wrinkles: An Experimental Clinical Trial |
| title_full | Evaluation of the Effect of Platelet Rich Fibrin Matrix in the Correction of Periorbital Wrinkles: An Experimental Clinical Trial |
| title_fullStr | Evaluation of the Effect of Platelet Rich Fibrin Matrix in the Correction of Periorbital Wrinkles: An Experimental Clinical Trial |
| title_full_unstemmed | Evaluation of the Effect of Platelet Rich Fibrin Matrix in the Correction of Periorbital Wrinkles: An Experimental Clinical Trial |
| title_short | Evaluation of the Effect of Platelet Rich Fibrin Matrix in the Correction of Periorbital Wrinkles: An Experimental Clinical Trial |
| title_sort | evaluation of the effect of platelet rich fibrin matrix in the correction of periorbital wrinkles an experimental clinical trial |
| topic | Platelet-rich fibrin matrix Skin Cosmetics |
| url | https://dpcj.org/index.php/dpc/article/view/2535 |
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