Intracerebroventricular Administration of an Endothelin ETB–Receptor Agonist Increases Expression of Matrix Metalloproteinase-2 and -9 in Rat Brain

Intracerebroventricular Administration of an Endothelin ETB–Receptor Agonist Increases Expression of Matrix Metalloproteinase-2 and -9 in Rat Brain

Abstract.: Matrix metalloproteinases (MMPs), a family of zinc-endopeptidases, have a critical role in the pathophysiological responses in damaged brains. MMPs are up-regulated in brain pathologies. To clarify the extracellular signals involved in brain MMP production, the effects of endothelins (ETs...

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Bibliographic Details
Main Authors:	Yutaka Koyama, Kazuhiro Tanaka
Format:	Article
Language:	English
Published:	Elsevier 2010-01-01
Series:	Journal of Pharmacological Sciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861319308217

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