Nanomaterial-based optical- and electrochemical-biosensors for urine glucose detection: A comprehensive review
Urine glucose detection is an important diagnostic tool for screening and early diagnosis of diabetes mellitus. Detection of urine glucose has many advantages over blood glucose, such as non-invasive, easy-to-detect, simple sampling and being well accepted by patients. Therefore, it is commonly used...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-09-01
|
| Series: | Advanced Sensor and Energy Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773045X22000164 |
| _version_ | 1828099856969760768 |
|---|---|
| author | Tian-Tian Wang Xiao-Feng Huang Hui Huang Pei Luo Lin-Sen Qing |
| author_facet | Tian-Tian Wang Xiao-Feng Huang Hui Huang Pei Luo Lin-Sen Qing |
| author_sort | Tian-Tian Wang |
| collection | DOAJ |
| description | Urine glucose detection is an important diagnostic tool for screening and early diagnosis of diabetes mellitus. Detection of urine glucose has many advantages over blood glucose, such as non-invasive, easy-to-detect, simple sampling and being well accepted by patients. Therefore, it is commonly used to monitor diabetes progression, assist in therapeutic intervention as well as in point-of-care testing (POCT). In recent years, with the development of material science, electrochemistry and miniaturization technology, novel applications of natural enzymes, nanozymes as well as nanomaterials, such as metal (Au, Pt, Ni, Co, etc.), alloy, grapheme, in the analysis of urine glucose level have been increasing sharply. In particular, different types of nanozymes-based biosensors, inspired by natural enzymes, have been developed with improved characteristics of being low-cost, stable, and mass-produced. On the other hand, making use of portable devices, such as smartphones and microfluidic paper-based analytical devices, has facilitated on site accurate urine glucose monitoring in real time. All these rapid advancements in nanotechnologies and devices have contributed greatly to the development of cost effective, highly sensitive, user friendly urine glucose biosensors. This review summarizes the most recent improvements in two major types of urine glucose biosensors: the optical- and electrochemical-biosensors. We also discuss the limitations, challenges and perspectives of these biosensors. Finally, we propose future research directions, development trends and potential clinical applications of nanomaterial-based biosensors developed for urine glucose detection. |
| first_indexed | 2024-04-11T08:20:13Z |
| format | Article |
| id | doaj.art-61b70f95b7e044c3932ee349db6574e8 |
| institution | Directory Open Access Journal |
| issn | 2773-045X |
| language | English |
| last_indexed | 2024-04-11T08:20:13Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advanced Sensor and Energy Materials |
| spelling | doaj.art-61b70f95b7e044c3932ee349db6574e82022-12-22T04:34:59ZengElsevierAdvanced Sensor and Energy Materials2773-045X2022-09-0113100016Nanomaterial-based optical- and electrochemical-biosensors for urine glucose detection: A comprehensive reviewTian-Tian Wang0Xiao-Feng Huang1Hui Huang2Pei Luo3Lin-Sen Qing4Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; State Key Laboratory for Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau 999078, ChinaChengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, ChinaDepartment of Cardiology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518000, ChinaState Key Laboratory for Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau 999078, China; Corresponding authors.Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; Corresponding authors.Urine glucose detection is an important diagnostic tool for screening and early diagnosis of diabetes mellitus. Detection of urine glucose has many advantages over blood glucose, such as non-invasive, easy-to-detect, simple sampling and being well accepted by patients. Therefore, it is commonly used to monitor diabetes progression, assist in therapeutic intervention as well as in point-of-care testing (POCT). In recent years, with the development of material science, electrochemistry and miniaturization technology, novel applications of natural enzymes, nanozymes as well as nanomaterials, such as metal (Au, Pt, Ni, Co, etc.), alloy, grapheme, in the analysis of urine glucose level have been increasing sharply. In particular, different types of nanozymes-based biosensors, inspired by natural enzymes, have been developed with improved characteristics of being low-cost, stable, and mass-produced. On the other hand, making use of portable devices, such as smartphones and microfluidic paper-based analytical devices, has facilitated on site accurate urine glucose monitoring in real time. All these rapid advancements in nanotechnologies and devices have contributed greatly to the development of cost effective, highly sensitive, user friendly urine glucose biosensors. This review summarizes the most recent improvements in two major types of urine glucose biosensors: the optical- and electrochemical-biosensors. We also discuss the limitations, challenges and perspectives of these biosensors. Finally, we propose future research directions, development trends and potential clinical applications of nanomaterial-based biosensors developed for urine glucose detection.http://www.sciencedirect.com/science/article/pii/S2773045X22000164Urine glucoseDiabetesBiosensorNanomaterialNanozyme |
| spellingShingle | Tian-Tian Wang Xiao-Feng Huang Hui Huang Pei Luo Lin-Sen Qing Nanomaterial-based optical- and electrochemical-biosensors for urine glucose detection: A comprehensive review Advanced Sensor and Energy Materials Urine glucose Diabetes Biosensor Nanomaterial Nanozyme |
| title | Nanomaterial-based optical- and electrochemical-biosensors for urine glucose detection: A comprehensive review |
| title_full | Nanomaterial-based optical- and electrochemical-biosensors for urine glucose detection: A comprehensive review |
| title_fullStr | Nanomaterial-based optical- and electrochemical-biosensors for urine glucose detection: A comprehensive review |
| title_full_unstemmed | Nanomaterial-based optical- and electrochemical-biosensors for urine glucose detection: A comprehensive review |
| title_short | Nanomaterial-based optical- and electrochemical-biosensors for urine glucose detection: A comprehensive review |
| title_sort | nanomaterial based optical and electrochemical biosensors for urine glucose detection a comprehensive review |
| topic | Urine glucose Diabetes Biosensor Nanomaterial Nanozyme |
| url | http://www.sciencedirect.com/science/article/pii/S2773045X22000164 |
| work_keys_str_mv | AT tiantianwang nanomaterialbasedopticalandelectrochemicalbiosensorsforurineglucosedetectionacomprehensivereview AT xiaofenghuang nanomaterialbasedopticalandelectrochemicalbiosensorsforurineglucosedetectionacomprehensivereview AT huihuang nanomaterialbasedopticalandelectrochemicalbiosensorsforurineglucosedetectionacomprehensivereview AT peiluo nanomaterialbasedopticalandelectrochemicalbiosensorsforurineglucosedetectionacomprehensivereview AT linsenqing nanomaterialbasedopticalandelectrochemicalbiosensorsforurineglucosedetectionacomprehensivereview |