Deuterium depletion induces anxiolytic-like effects in rats
Deuterium-depleted water (DDW) has a concentration of deuterium 6-7 times lower than naturally occurring water (20-25 ppm vs. 150 ppm). When administered for a longer period, it can reduce the concentration of deuterium throughout the body, activating cellular mechanisms that depend on p...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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University of Belgrade, University of Novi Sad
2014-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402947M.pdf |
| _version_ | 1818215459705585664 |
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| author | Mladin Cristian Ciobica Alin Lefter Radu Popescu Alexandru Bild Walther |
| author_facet | Mladin Cristian Ciobica Alin Lefter Radu Popescu Alexandru Bild Walther |
| author_sort | Mladin Cristian |
| collection | DOAJ |
| description | Deuterium-depleted water (DDW) has a concentration of deuterium 6-7 times
lower than naturally occurring water (20-25 ppm vs. 150 ppm). When
administered for a longer period, it can reduce the concentration of
deuterium throughout the body, activating cellular mechanisms that depend on
protons. The aim of the present work was to investigate the influence of
chronic DDW administration on anxiety-related processes in Wistar rats when
compared to a control group that received distilled water, as studied in an
elevated plus maze behavioral test. Our results describe a possible
anxiolytic-like effect of DDW administration on rats, as shown by the
increase in the percentage of time and number of entries in the open arms of
the elevated plus maze. The administration of DDW also resulted in stimulated
head-dipping behavior in the open arms, which is a behavioral change that
characterizes the exploratory behavior and decreased inhibition/ fear in an
unfamiliar environment. We conclude that the change in this balance may have
important consequences for many biological mechanisms. A deuterium
desaturation treatment with DDW might have a use in anxiety disorders. |
| first_indexed | 2024-12-12T06:36:25Z |
| format | Article |
| id | doaj.art-61b8b06bfb074f0baad202e99bd50ab5 |
| institution | Directory Open Access Journal |
| issn | 0354-4664 1821-4339 |
| language | English |
| last_indexed | 2024-12-12T06:36:25Z |
| publishDate | 2014-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj.art-61b8b06bfb074f0baad202e99bd50ab52022-12-22T00:34:28ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46641821-43392014-01-0166294795310.2298/ABS1402947M0354-46641402947MDeuterium depletion induces anxiolytic-like effects in ratsMladin Cristian0Ciobica Alin1Lefter Radu2Popescu Alexandru3Bild Walther4University of Craiova, Faculty of Chemistry, Craiova, Romania“Alexandru Ioan Cuza” University, Iasi, Romania + Center of Biomedical Research of the Romanian Academy, Iasi Branch, Romania“Alexandru Ioan Cuza” University, Iasi, RomaniaUniversity of Craiova, Faculty of Chemistry, Craiova, RomaniaCenter of Biomedical Research of the Romanian Academy, Iasi Branch, Romania + “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, RomaniaDeuterium-depleted water (DDW) has a concentration of deuterium 6-7 times lower than naturally occurring water (20-25 ppm vs. 150 ppm). When administered for a longer period, it can reduce the concentration of deuterium throughout the body, activating cellular mechanisms that depend on protons. The aim of the present work was to investigate the influence of chronic DDW administration on anxiety-related processes in Wistar rats when compared to a control group that received distilled water, as studied in an elevated plus maze behavioral test. Our results describe a possible anxiolytic-like effect of DDW administration on rats, as shown by the increase in the percentage of time and number of entries in the open arms of the elevated plus maze. The administration of DDW also resulted in stimulated head-dipping behavior in the open arms, which is a behavioral change that characterizes the exploratory behavior and decreased inhibition/ fear in an unfamiliar environment. We conclude that the change in this balance may have important consequences for many biological mechanisms. A deuterium desaturation treatment with DDW might have a use in anxiety disorders.http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402947M.pdfDeuterium-depleted wateranxietyelevated plus maze |
| spellingShingle | Mladin Cristian Ciobica Alin Lefter Radu Popescu Alexandru Bild Walther Deuterium depletion induces anxiolytic-like effects in rats Archives of Biological Sciences Deuterium-depleted water anxiety elevated plus maze |
| title | Deuterium depletion induces anxiolytic-like effects in rats |
| title_full | Deuterium depletion induces anxiolytic-like effects in rats |
| title_fullStr | Deuterium depletion induces anxiolytic-like effects in rats |
| title_full_unstemmed | Deuterium depletion induces anxiolytic-like effects in rats |
| title_short | Deuterium depletion induces anxiolytic-like effects in rats |
| title_sort | deuterium depletion induces anxiolytic like effects in rats |
| topic | Deuterium-depleted water anxiety elevated plus maze |
| url | http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402947M.pdf |
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