Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis

Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis

Enhancement of glial-derived neurotrophic factor (GDNF) is an established therapeutic target for amyotrophic lateral sclerosis (ALS). Activation of group II metabotropic glutamate (mGlu) receptors with the orthosteric agonist, LY379268, enhanced GDNF levels in cultured spinal cord astrocytes from wi...

Descrizione completa

Dettagli Bibliografici
Autori principali:	Giuseppe Battaglia, Barbara Riozzi, Domenico Bucci, Luisa Di Menna, Gemma Molinaro, Simone Pallottino, Ferdinando Nicoletti, Valeria Bruno
Natura:	Articolo
Lingua:	English
Pubblicazione:	Elsevier 2015-02-01
Serie:	Neurobiology of Disease
Soggetti:	Metabotropic glutamate receptor Neurodegeneration Neuroprotection Amyotrophic lateral sclerosis GDNF GLT-1
Accesso online:	http://www.sciencedirect.com/science/article/pii/S096999611400357X

Documenti analoghi

mGlu5 Receptor Functional Interactions and Addiction
di: Robyn eBrown, et al.
Pubblicazione: (2012-05-01)

mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists
di: Copani Agata, et al.
Pubblicazione: (2011-01-01)

A type-5 metabotropic glutamate receptor-perineuronal net axis shapes the function of cortical GABAergic interneurons in chronic pain
di: Giada Mascio, et al.
Pubblicazione: (2025-02-01)

The mGlu7 receptor provides protective effects against epileptogenesis and epileptic seizures
di: Benoit Girard, et al.
Pubblicazione: (2019-09-01)

Knocking down metabotropic glutamate receptor 1 improves survival and disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis
di: Marco Milanese, et al.
Pubblicazione: (2014-04-01)

GLT-1 Knockdown Inhibits Ceftriaxone-Mediated Improvements on Cognitive Deficits, and GLT-1 and xCT Expression and Activity in APP/PS1 AD Mice
di: JunXia Gao, et al.
Pubblicazione: (2020-10-01)

mGlu2 mechanism-based interventions to treat alcohol relapse
di: Valentina Vengeliene, et al.
Pubblicazione: (2022-09-01)

Glycosyltransferase GLT8D1 and GLT8D2 serve as potential prognostic biomarkers correlated with Tumor Immunity in Gastric Cancer
di: Huimei Xu, et al.
Pubblicazione: (2023-06-01)

Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia
di: Federica Mastroiacovo, et al.
Pubblicazione: (2017-08-01)

Negative Allosteric Modulators of mGlu7 Receptor as Putative Antipsychotic Drugs
di: Paulina Cieślik, et al.
Pubblicazione: (2018-09-01)

Targeting mGlu5 Metabotropic Glutamate Receptors in the Treatment of Cognitive Dysfunction in a Mouse Model of Phenylketonuria
di: Francesca Nardecchia, et al.
Pubblicazione: (2018-03-01)

Can Metabotropic Glutamate Receptor 7 (mGluR 7) be a Novel Target for Analgesia?
di: Shivaprakash G, et al.
Pubblicazione: (2014-09-01)

Group I metabotropic glutamate receptors (mGluR1/5) and neurodegenerative diseases
di: Elena I. Solntseva, et al.
Pubblicazione: (2019-12-01)

Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception
di: Crock Lara W, et al.
Pubblicazione: (2012-03-01)

Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection?
di: Simona Federica Spampinato, et al.
Pubblicazione: (2018-11-01)

Control of Theta Oscillatory Activity Underlying Fear Expression by mGlu<sub>5</sub> Receptors
di: Pawel Matulewicz, et al.
Pubblicazione: (2022-11-01)

Biology of GDNF and its receptors — Relevance for disorders of the central nervous system
di: Carlos F. Ibáñez, et al.
Pubblicazione: (2017-01-01)

Metabotropic glutamate receptors (mGluRs) in epileptogenesis: an update on abnormal mGluRs signaling and its therapeutic implications
di: Leyi Huang, et al.
Pubblicazione: (2024-01-01)

Metabotropic glutamate receptor 5 (mGluR5) regulates white adipocyte browning
di: LUO Xie, ZENG Li, YUAN Lei
Pubblicazione: (2021-01-01)

The Role of Metals in the Neuroregenerative Action of BDNF, GDNF, NGF and Other Neurotrophic Factors
di: Vincenzo Giuseppe Nicoletti, et al.
Pubblicazione: (2022-07-01)

Role of astrocytes and glutamate transporter EAAT2 / GLT1 in Amyotrophic Lateral Sclerosis
di: Daniel Castro, et al.
Pubblicazione: (2017-11-01)

Chronic Treatment with Fluoxetine Induces Sex-Dependent Analgesic Effects and Modulates HDAC2 and mGlu2 Expression in Female Mice
di: Magda Zammataro, et al.
Pubblicazione: (2017-10-01)

Long-term, stable, targeted biodelivery and efficacy of GDNF from encapsulated cells in the rat and Goettingen miniature pig brain
di: Lars U. Wahlberg, et al.
Pubblicazione: (2020-04-01)

A Modified GLT Double Faults Isolation Approach Based on MLE and RPV for Six-Gyro Redundant SINS
di: Jianhua Cheng, et al.
Pubblicazione: (2019-01-01)

Encephalitis Associated to Metabotropic Glutamate Receptor 5 (mGluR5) Antibodies in Cerebrospinal Fluid
di: Carlos Guevara, et al.
Pubblicazione: (2018-11-01)

mGlu5 Receptor Blockade Within the Nucleus Accumbens Shell Reduces Behavioral Indices of Alcohol Withdrawal-Induced Anxiety in Mice
di: Kaziya M. Lee, et al.
Pubblicazione: (2018-11-01)

EVALUATION OF IMPACT OF ELEVATED TEMPERATURES ON YOUNG’S MODULUS OF GLT BEAMS
di: Lucie Kucíková, et al.
Pubblicazione: (2021-04-01)

Study of GDNF-Family Receptor Alpha 2 And Inhibitory Activity of GDNF-Family Receptor Alpha 2b (GFRα2b) Isoform
di: Yoong, Li Foong, et al.
Pubblicazione: (2005)

Downregulation of surface AMPA receptor expression in the striatum following prolonged social isolation, a role of mGlu5 receptors
di: Li-Min Mao, et al.
Pubblicazione: (2022-12-01)

Kainic Acid and MPP+ Induce Upregulation of GLT-1 in Neuroblastoma and Glia Cells
di: Rabia UYARICI, et al.
Pubblicazione: (2021-04-01)

GDNF and the RET Receptor in Cancer: New Insights and Therapeutic Potential
di: Lois M. Mulligan
Pubblicazione: (2019-01-01)

The role of mGlu4 receptors within the nucleus accumbens in acquisition and expression of morphine-induced conditioned place preference in male rats
di: Zahra Ebrahimi, et al.
Pubblicazione: (2021-03-01)

Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice
di: Lane, T, et al.
Pubblicazione: (2013)

Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice.
di: Lane, T, et al.
Pubblicazione: (2013)

The pre-teatment effect of voluntary exercise by GDNF on lesion injectioned by 6- hydroxydopamine in brain stem of male rats Abstract
di: راضیه محمدی, et al.
Pubblicazione: (2014-04-01)

Role of Metabotropic Glutamate Receptors in Neurological Disorders
di: Rosalia Crupi, et al.
Pubblicazione: (2019-02-01)

MiRNAs Mediate GDNF-Induced Proliferation and Migration of Glioma Cells
di: Bao-Le Zhang, et al.
Pubblicazione: (2017-12-01)

GDNF protects enteric glia from apoptosis: evidence for an autocrine loop
di: Steinkamp Martin, et al.
Pubblicazione: (2012-01-01)

GLT1 overexpression in SOD1G93A mouse cervical spinal cord does not preserve diaphragm function or extend disease
di: Ke Li, et al.
Pubblicazione: (2015-06-01)

A ‘double-edged’ role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs
di: Serena Notartomaso, et al.
Pubblicazione: (2024-08-01)