Polygenic risk for major depression, attention deficit hyperactivity disorder, neuroticism, and schizophrenia are correlated with experience of intimate partner violence
Abstract Research has suggested that mental illness may be a risk factor for, as well as a sequela of, experiencing intimate partner violence (IPV). The association between IPV and mental illness may also be due in part to gene-environment correlations. Using polygenic risk scores for six psychiatri...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2024-02-01
|
| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-024-02814-1 |
| _version_ | 1797273167590326272 |
|---|---|
| author | Andrew Ratanatharathorn Luwei Quan Karestan C. Koenen Lori B. Chibnik Marc G. Weisskopf Natalie Slopen Andrea L. Roberts |
| author_facet | Andrew Ratanatharathorn Luwei Quan Karestan C. Koenen Lori B. Chibnik Marc G. Weisskopf Natalie Slopen Andrea L. Roberts |
| author_sort | Andrew Ratanatharathorn |
| collection | DOAJ |
| description | Abstract Research has suggested that mental illness may be a risk factor for, as well as a sequela of, experiencing intimate partner violence (IPV). The association between IPV and mental illness may also be due in part to gene-environment correlations. Using polygenic risk scores for six psychiatric disorders - attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BPD), major depressive disorder (MDD), neuroticism, and schizophrenia—and a combined measure of overall genetic risk for mental illness, we tested whether women’s genetic risk for mental illness was associated with the experience of three types of intimate partner violence. In this cohort of women of European ancestry (N = 11,095), participants in the highest quintile of genetic risk for ADHD (OR range: 1.38–1.49), MDD (OR range: 1.28–1.43), neuroticism (OR range: (1.18–1.25), schizophrenia (OR range: 1.30–1.34), and overall genetic risk (OR range: 1.30–1.41) were at higher risk for experiencing more severe emotional and physical abuse, and, except schizophrenia, more severe sexual abuse, as well as more types of abuse and chronic abuse. In addition, participants in the highest quintile of genetic risk for neuroticism (OR = 1.43 95% CI: 1.18, 1.72), schizophrenia (OR = 1.33 95% CI: 1.10, 1.62), and the overall genetic risk (OR = 1.40 95% CI: 1.15, 1.71) were at higher risk for experiencing intimate partner intimidation and control. Participants in the highest quintile of genetic risk for ADHD, ASD, MDD, schizophrenia, and overall genetic risk, compared to the lowest quintile, were at increased risk for experiencing harassment from a partner (OR range: 1.22–1.92). No associations were found between genetic risk for BPD with IPV. A better understanding of the salience of the multiple possible pathways linking genetic risk for mental illness with risk for IPV may aid in preventing IPV victimization or re-victimization. |
| first_indexed | 2024-03-07T14:39:42Z |
| format | Article |
| id | doaj.art-61bab0bdd9d14cc5a30efb65cb3f1cc4 |
| institution | Directory Open Access Journal |
| issn | 2158-3188 |
| language | English |
| last_indexed | 2024-03-07T14:39:42Z |
| publishDate | 2024-02-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj.art-61bab0bdd9d14cc5a30efb65cb3f1cc42024-03-05T20:26:16ZengNature Publishing GroupTranslational Psychiatry2158-31882024-02-011411810.1038/s41398-024-02814-1Polygenic risk for major depression, attention deficit hyperactivity disorder, neuroticism, and schizophrenia are correlated with experience of intimate partner violenceAndrew Ratanatharathorn0Luwei Quan1Karestan C. Koenen2Lori B. Chibnik3Marc G. Weisskopf4Natalie Slopen5Andrea L. Roberts6Department of Epidemiology, Columbia University Mailman School of Public HealthDepartment of Environmental Health, Harvard T.H. Chan School of Public HealthDepartment of Epidemiology, Harvard T.H. Chan School of Public HealthDepartment of Epidemiology, Harvard T.H. Chan School of Public HealthDepartment of Epidemiology, Harvard T.H. Chan School of Public HealthDepartment of Social and Behavioral Sciences, Harvard T.H. Chan School of Public HealthDepartment of Environmental Health, Harvard T.H. Chan School of Public HealthAbstract Research has suggested that mental illness may be a risk factor for, as well as a sequela of, experiencing intimate partner violence (IPV). The association between IPV and mental illness may also be due in part to gene-environment correlations. Using polygenic risk scores for six psychiatric disorders - attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BPD), major depressive disorder (MDD), neuroticism, and schizophrenia—and a combined measure of overall genetic risk for mental illness, we tested whether women’s genetic risk for mental illness was associated with the experience of three types of intimate partner violence. In this cohort of women of European ancestry (N = 11,095), participants in the highest quintile of genetic risk for ADHD (OR range: 1.38–1.49), MDD (OR range: 1.28–1.43), neuroticism (OR range: (1.18–1.25), schizophrenia (OR range: 1.30–1.34), and overall genetic risk (OR range: 1.30–1.41) were at higher risk for experiencing more severe emotional and physical abuse, and, except schizophrenia, more severe sexual abuse, as well as more types of abuse and chronic abuse. In addition, participants in the highest quintile of genetic risk for neuroticism (OR = 1.43 95% CI: 1.18, 1.72), schizophrenia (OR = 1.33 95% CI: 1.10, 1.62), and the overall genetic risk (OR = 1.40 95% CI: 1.15, 1.71) were at higher risk for experiencing intimate partner intimidation and control. Participants in the highest quintile of genetic risk for ADHD, ASD, MDD, schizophrenia, and overall genetic risk, compared to the lowest quintile, were at increased risk for experiencing harassment from a partner (OR range: 1.22–1.92). No associations were found between genetic risk for BPD with IPV. A better understanding of the salience of the multiple possible pathways linking genetic risk for mental illness with risk for IPV may aid in preventing IPV victimization or re-victimization.https://doi.org/10.1038/s41398-024-02814-1 |
| spellingShingle | Andrew Ratanatharathorn Luwei Quan Karestan C. Koenen Lori B. Chibnik Marc G. Weisskopf Natalie Slopen Andrea L. Roberts Polygenic risk for major depression, attention deficit hyperactivity disorder, neuroticism, and schizophrenia are correlated with experience of intimate partner violence Translational Psychiatry |
| title | Polygenic risk for major depression, attention deficit hyperactivity disorder, neuroticism, and schizophrenia are correlated with experience of intimate partner violence |
| title_full | Polygenic risk for major depression, attention deficit hyperactivity disorder, neuroticism, and schizophrenia are correlated with experience of intimate partner violence |
| title_fullStr | Polygenic risk for major depression, attention deficit hyperactivity disorder, neuroticism, and schizophrenia are correlated with experience of intimate partner violence |
| title_full_unstemmed | Polygenic risk for major depression, attention deficit hyperactivity disorder, neuroticism, and schizophrenia are correlated with experience of intimate partner violence |
| title_short | Polygenic risk for major depression, attention deficit hyperactivity disorder, neuroticism, and schizophrenia are correlated with experience of intimate partner violence |
| title_sort | polygenic risk for major depression attention deficit hyperactivity disorder neuroticism and schizophrenia are correlated with experience of intimate partner violence |
| url | https://doi.org/10.1038/s41398-024-02814-1 |
| work_keys_str_mv | AT andrewratanatharathorn polygenicriskformajordepressionattentiondeficithyperactivitydisorderneuroticismandschizophreniaarecorrelatedwithexperienceofintimatepartnerviolence AT luweiquan polygenicriskformajordepressionattentiondeficithyperactivitydisorderneuroticismandschizophreniaarecorrelatedwithexperienceofintimatepartnerviolence AT karestanckoenen polygenicriskformajordepressionattentiondeficithyperactivitydisorderneuroticismandschizophreniaarecorrelatedwithexperienceofintimatepartnerviolence AT loribchibnik polygenicriskformajordepressionattentiondeficithyperactivitydisorderneuroticismandschizophreniaarecorrelatedwithexperienceofintimatepartnerviolence AT marcgweisskopf polygenicriskformajordepressionattentiondeficithyperactivitydisorderneuroticismandschizophreniaarecorrelatedwithexperienceofintimatepartnerviolence AT natalieslopen polygenicriskformajordepressionattentiondeficithyperactivitydisorderneuroticismandschizophreniaarecorrelatedwithexperienceofintimatepartnerviolence AT andrealroberts polygenicriskformajordepressionattentiondeficithyperactivitydisorderneuroticismandschizophreniaarecorrelatedwithexperienceofintimatepartnerviolence |