John William Trevan’s concept of Median Lethal Dose (LD50/LC50) – more misused than used

John William Trevan’s concept of Median Lethal Dose (LD50/LC50) – more misused than used

Introduction Median lethal dose (MLD) has been a controversial subject among biologists and animal ethicists since its inception in 1927 by Trevan. Toxicologists use MLD (LD50) as the first step to assess the toxicity of a substance. Animal ethicists criticize LD50 tests because animals suffer pain,...

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Bibliographic Details
Main Authors: Sadasivan Kalathil Pillai, Katsumi Kobayashi, Mathews Michael, Thomson Mathai, Bhavana Sivakumar, Parvathy Sadasivan
Format: Article
Language:English
Published: Institute of Rural Health 2021-07-01
Series:Journal of Pre-Clinical and Clinical Research
Subjects:
ld50
jw trevan
acute toxicity
median lethal dose
mld
litchfield and wicoxon
Online Access:https://www.jpccr.eu/John-William-Trevan-s-concept-of-Median-Lethal-Dose-LD50-LC50-more-misused-than-used,139588,0,2.html

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