PRACTICAL ASPECTS OF ADMINISTERING CYCLIN-DEPENDENT KINASES INHIBITORS: EFFICACY AND TOLERABILITY
Although metastatic breast cancer remains an incurable disease, significant achievements have been made in this area over the recent years, allowing to convert breast cancer into a chronically controlled disease characterized by a torpid course. Patients with hormone-sensitive HER2-negative cancer a...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2018-04-01
|
| Series: | Опухоли женской репродуктивной системы |
| Subjects: | |
| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/578 |
| _version_ | 1797876004712087552 |
|---|---|
| author | E. V. Artamonova |
| author_facet | E. V. Artamonova |
| author_sort | E. V. Artamonova |
| collection | DOAJ |
| description | Although metastatic breast cancer remains an incurable disease, significant achievements have been made in this area over the recent years, allowing to convert breast cancer into a chronically controlled disease characterized by a torpid course. Patients with hormone-sensitive HER2-negative cancer are more likely to achieve this relatively favorable clinical outcome. It became possible with the development and implementation of highly effective combination treatment regimens that include recently developed inhibitors of cyclin-dependent kinases (CDK) 4 and 6. This article presents an overview of randomized clinical trials assessing the efficacy and safety of CDK4/6 inhibitors. It is shown that neutropenia is class-specific undesirable effect and characterizes all 3 drugs (palbociclib, ribociclib, abemaciclib); ribociclib therapy, in addition, is associated with hepatoand cardiotoxicity (prolongation of QTc interval); abemaciclib, in addition to neutropenia, is characterized by diarrhea and thromboembolic events. |
| first_indexed | 2024-04-10T01:56:27Z |
| format | Article |
| id | doaj.art-61bedc041cea4568be1ae89785a7b7b9 |
| institution | Directory Open Access Journal |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| last_indexed | 2024-04-10T01:56:27Z |
| publishDate | 2018-04-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj.art-61bedc041cea4568be1ae89785a7b7b92023-03-13T08:44:36ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272018-04-01141526010.17650/1994-4098-2018-14-1-52-60563PRACTICAL ASPECTS OF ADMINISTERING CYCLIN-DEPENDENT KINASES INHIBITORS: EFFICACY AND TOLERABILITYE. V. Artamonova0ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииAlthough metastatic breast cancer remains an incurable disease, significant achievements have been made in this area over the recent years, allowing to convert breast cancer into a chronically controlled disease characterized by a torpid course. Patients with hormone-sensitive HER2-negative cancer are more likely to achieve this relatively favorable clinical outcome. It became possible with the development and implementation of highly effective combination treatment regimens that include recently developed inhibitors of cyclin-dependent kinases (CDK) 4 and 6. This article presents an overview of randomized clinical trials assessing the efficacy and safety of CDK4/6 inhibitors. It is shown that neutropenia is class-specific undesirable effect and characterizes all 3 drugs (palbociclib, ribociclib, abemaciclib); ribociclib therapy, in addition, is associated with hepatoand cardiotoxicity (prolongation of QTc interval); abemaciclib, in addition to neutropenia, is characterized by diarrhea and thromboembolic events.https://ojrs.abvpress.ru/ojrs/article/view/578метастатический рак молочной железыгормонотерапияпалбоциклибрибоциклибабемациклиб |
| spellingShingle | E. V. Artamonova PRACTICAL ASPECTS OF ADMINISTERING CYCLIN-DEPENDENT KINASES INHIBITORS: EFFICACY AND TOLERABILITY Опухоли женской репродуктивной системы метастатический рак молочной железы гормонотерапия палбоциклиб рибоциклиб абемациклиб |
| title | PRACTICAL ASPECTS OF ADMINISTERING CYCLIN-DEPENDENT KINASES INHIBITORS: EFFICACY AND TOLERABILITY |
| title_full | PRACTICAL ASPECTS OF ADMINISTERING CYCLIN-DEPENDENT KINASES INHIBITORS: EFFICACY AND TOLERABILITY |
| title_fullStr | PRACTICAL ASPECTS OF ADMINISTERING CYCLIN-DEPENDENT KINASES INHIBITORS: EFFICACY AND TOLERABILITY |
| title_full_unstemmed | PRACTICAL ASPECTS OF ADMINISTERING CYCLIN-DEPENDENT KINASES INHIBITORS: EFFICACY AND TOLERABILITY |
| title_short | PRACTICAL ASPECTS OF ADMINISTERING CYCLIN-DEPENDENT KINASES INHIBITORS: EFFICACY AND TOLERABILITY |
| title_sort | practical aspects of administering cyclin dependent kinases inhibitors efficacy and tolerability |
| topic | метастатический рак молочной железы гормонотерапия палбоциклиб рибоциклиб абемациклиб |
| url | https://ojrs.abvpress.ru/ojrs/article/view/578 |
| work_keys_str_mv | AT evartamonova practicalaspectsofadministeringcyclindependentkinasesinhibitorsefficacyandtolerability |