NMN partially rescues cuproptosis by upregulating sirt2 to increase intracellular NADPH

NMN partially rescues cuproptosis by upregulating sirt2 to increase intracellular NADPH

Abstract Cuproptosis is characterized by lipoylated protein aggregation and loss of iron–sulfur (Fe–S) proteins, which are crucial for a wide range of important cellular functions, including DNA replication and damage repair. Sirt2 and sirt4 are lipoamidases that remove the lipoyl moiety from lipoyl...

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Bibliographic Details
Main Authors: Yingying Zhang, Shuting Qiu, Shihan Shao, Yuejia Cao, Yu Hong, Xianrong Xu, Xuexian Fang, Chunhong Di, Jun Yang, Xiaohua Tan
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:Scientific Reports
Subjects:
Cuproptosis
DNA damage response
Nicotinamide mononucleotide
sirt2
NADPH
Online Access:https://doi.org/10.1038/s41598-024-70245-5

Internet

https://doi.org/10.1038/s41598-024-70245-5

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