Neural decoding reveals specialized kinematic tuning after an abrupt cortical transition
Summary: The primary motor cortex (M1) exhibits a protracted period of development, including the development of a sensory representation long before motor outflow emerges. In rats, this representation is present by postnatal day (P) 8, when M1 activity is “discontinuous.” Here, we ask how the repre...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-09-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723011312 |
| _version_ | 1797689274497236992 |
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| author | Ryan M. Glanz Greta Sokoloff Mark S. Blumberg |
| author_facet | Ryan M. Glanz Greta Sokoloff Mark S. Blumberg |
| author_sort | Ryan M. Glanz |
| collection | DOAJ |
| description | Summary: The primary motor cortex (M1) exhibits a protracted period of development, including the development of a sensory representation long before motor outflow emerges. In rats, this representation is present by postnatal day (P) 8, when M1 activity is “discontinuous.” Here, we ask how the representation changes upon the transition to “continuous” activity at P12. We use neural decoding to predict forelimb movements from M1 activity and show that a linear decoder effectively predicts limb movements at P8 but not at P12; instead, a nonlinear decoder better predicts limb movements at P12. The altered decoder performance reflects increased complexity and uniqueness of kinematic information in M1. We next show that M1’s representation at P12 is more susceptible to “lesioning” of inputs and “transplanting” of M1’s encoding scheme from one pup to another. Thus, the emergence of continuous M1 activity signals the developmental onset of more complex, informationally sparse, and individualized sensory representations. |
| first_indexed | 2024-03-12T01:43:23Z |
| format | Article |
| id | doaj.art-61c2ae4b637843aba453b920ff69306b |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-12T01:43:23Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-61c2ae4b637843aba453b920ff69306b2023-09-10T04:24:04ZengElsevierCell Reports2211-12472023-09-01429113119Neural decoding reveals specialized kinematic tuning after an abrupt cortical transitionRyan M. Glanz0Greta Sokoloff1Mark S. Blumberg2Department of Psychological & Brain Sciences, University of Iowa, Iowa City, IA 52242, USADepartment of Psychological & Brain Sciences, University of Iowa, Iowa City, IA 52242, USA; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242, USADepartment of Psychological & Brain Sciences, University of Iowa, Iowa City, IA 52242, USA; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242, USA; Corresponding authorSummary: The primary motor cortex (M1) exhibits a protracted period of development, including the development of a sensory representation long before motor outflow emerges. In rats, this representation is present by postnatal day (P) 8, when M1 activity is “discontinuous.” Here, we ask how the representation changes upon the transition to “continuous” activity at P12. We use neural decoding to predict forelimb movements from M1 activity and show that a linear decoder effectively predicts limb movements at P8 but not at P12; instead, a nonlinear decoder better predicts limb movements at P12. The altered decoder performance reflects increased complexity and uniqueness of kinematic information in M1. We next show that M1’s representation at P12 is more susceptible to “lesioning” of inputs and “transplanting” of M1’s encoding scheme from one pup to another. Thus, the emergence of continuous M1 activity signals the developmental onset of more complex, informationally sparse, and individualized sensory representations.http://www.sciencedirect.com/science/article/pii/S2211124723011312CP: Neuroscience |
| spellingShingle | Ryan M. Glanz Greta Sokoloff Mark S. Blumberg Neural decoding reveals specialized kinematic tuning after an abrupt cortical transition Cell Reports CP: Neuroscience |
| title | Neural decoding reveals specialized kinematic tuning after an abrupt cortical transition |
| title_full | Neural decoding reveals specialized kinematic tuning after an abrupt cortical transition |
| title_fullStr | Neural decoding reveals specialized kinematic tuning after an abrupt cortical transition |
| title_full_unstemmed | Neural decoding reveals specialized kinematic tuning after an abrupt cortical transition |
| title_short | Neural decoding reveals specialized kinematic tuning after an abrupt cortical transition |
| title_sort | neural decoding reveals specialized kinematic tuning after an abrupt cortical transition |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723011312 |
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