Clinical Assessment of Acute Organophosphorus Pesticide Poisoning in Pediatric Patients Admitted to the Toxicology Emergency Department
Pesticide poisoning in pediatric patients is still an important reason for presenting to the emergency department in Romania. In this context, the present study aims to raise awareness of the toxicological impact of pesticides on human health in pediatrics. For this purpose, the demographic characte...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/10/10/582 |
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| author | Ioana-Cezara Caba Violeta Ștreangă Mona-Elisabeta Dobrin Cristina Jităreanu Alexandra Jităreanu Bianca-Ștefania Profire Maria Apotrosoaei Alin-Viorel Focșa Bogdan Caba Luminița Agoroaei |
| author_facet | Ioana-Cezara Caba Violeta Ștreangă Mona-Elisabeta Dobrin Cristina Jităreanu Alexandra Jităreanu Bianca-Ștefania Profire Maria Apotrosoaei Alin-Viorel Focșa Bogdan Caba Luminița Agoroaei |
| author_sort | Ioana-Cezara Caba |
| collection | DOAJ |
| description | Pesticide poisoning in pediatric patients is still an important reason for presenting to the emergency department in Romania. In this context, the present study aims to raise awareness of the toxicological impact of pesticides on human health in pediatrics. For this purpose, the demographic characteristics, clinical assessment, and outcome of pediatric patients with acute pesticide poisoning admitted to the toxicology department of “Saint Mary” Emergency Children’s Hospital from Iasi, were analyzed. This retrospective study focused on the clinical and laboratory data of patients aged under 18 years diagnosed with acute pesticide poisoning between 2010–2020. The statistical analysis was performed using the Statistica 10 package. A total of 49 patients presented with manifestations of acute pesticide poisoning, and the most common pesticide involved was diazinon. The most frequent exposure route was accidentally ingesting pesticide products (95%). The primary clinical manifestations were toxic encephalopathy, coma, depressive disorder, gastric disorders, and respiratory failure. Changes in the glycemic status, liver, and kidney damage were also present. Treatment included decontamination, administration of antidote, supportive care, and recommendations to be closely monitored to avoid a new incident. These results highlight the toxic potential of pesticides on human health and their biological consequences, which require an increase in consciousness of the precautions imposed on their use, especially when children are nearby. |
| first_indexed | 2024-03-09T19:25:47Z |
| format | Article |
| id | doaj.art-61c4349eef484416ad7507c76655907d |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-09T19:25:47Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-61c4349eef484416ad7507c76655907d2023-11-24T02:57:28ZengMDPI AGToxics2305-63042022-10-01101058210.3390/toxics10100582Clinical Assessment of Acute Organophosphorus Pesticide Poisoning in Pediatric Patients Admitted to the Toxicology Emergency DepartmentIoana-Cezara Caba0Violeta Ștreangă1Mona-Elisabeta Dobrin2Cristina Jităreanu3Alexandra Jităreanu4Bianca-Ștefania Profire5Maria Apotrosoaei6Alin-Viorel Focșa7Bogdan Caba8Luminița Agoroaei9Department of Toxicology, Faculty of Pharmacy, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, RomaniaDepartment of Toxicology, “Saint Mary” Children Emergency Hospital, 700309 Iasi, RomaniaDepartment of Clinical Biochemistry, Clinical Hospital of Pulmonary Disease, 700115 Iasi, RomaniaDepartment of Toxicology, “Saint Mary” Children Emergency Hospital, 700309 Iasi, RomaniaDepartment of Toxicology, Faculty of Pharmacy, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, RomaniaDepartment of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, RomaniaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, RomaniaDepartment of Drug Industry and Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, RomaniaDepartment of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, RomaniaDepartment of Toxicology, Faculty of Pharmacy, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, RomaniaPesticide poisoning in pediatric patients is still an important reason for presenting to the emergency department in Romania. In this context, the present study aims to raise awareness of the toxicological impact of pesticides on human health in pediatrics. For this purpose, the demographic characteristics, clinical assessment, and outcome of pediatric patients with acute pesticide poisoning admitted to the toxicology department of “Saint Mary” Emergency Children’s Hospital from Iasi, were analyzed. This retrospective study focused on the clinical and laboratory data of patients aged under 18 years diagnosed with acute pesticide poisoning between 2010–2020. The statistical analysis was performed using the Statistica 10 package. A total of 49 patients presented with manifestations of acute pesticide poisoning, and the most common pesticide involved was diazinon. The most frequent exposure route was accidentally ingesting pesticide products (95%). The primary clinical manifestations were toxic encephalopathy, coma, depressive disorder, gastric disorders, and respiratory failure. Changes in the glycemic status, liver, and kidney damage were also present. Treatment included decontamination, administration of antidote, supportive care, and recommendations to be closely monitored to avoid a new incident. These results highlight the toxic potential of pesticides on human health and their biological consequences, which require an increase in consciousness of the precautions imposed on their use, especially when children are nearby.https://www.mdpi.com/2305-6304/10/10/582organophosphate pesticide poisoningtoxicity of pesticidespediatric patientsbiochemical parametersclinical toxicology assessment |
| spellingShingle | Ioana-Cezara Caba Violeta Ștreangă Mona-Elisabeta Dobrin Cristina Jităreanu Alexandra Jităreanu Bianca-Ștefania Profire Maria Apotrosoaei Alin-Viorel Focșa Bogdan Caba Luminița Agoroaei Clinical Assessment of Acute Organophosphorus Pesticide Poisoning in Pediatric Patients Admitted to the Toxicology Emergency Department Toxics organophosphate pesticide poisoning toxicity of pesticides pediatric patients biochemical parameters clinical toxicology assessment |
| title | Clinical Assessment of Acute Organophosphorus Pesticide Poisoning in Pediatric Patients Admitted to the Toxicology Emergency Department |
| title_full | Clinical Assessment of Acute Organophosphorus Pesticide Poisoning in Pediatric Patients Admitted to the Toxicology Emergency Department |
| title_fullStr | Clinical Assessment of Acute Organophosphorus Pesticide Poisoning in Pediatric Patients Admitted to the Toxicology Emergency Department |
| title_full_unstemmed | Clinical Assessment of Acute Organophosphorus Pesticide Poisoning in Pediatric Patients Admitted to the Toxicology Emergency Department |
| title_short | Clinical Assessment of Acute Organophosphorus Pesticide Poisoning in Pediatric Patients Admitted to the Toxicology Emergency Department |
| title_sort | clinical assessment of acute organophosphorus pesticide poisoning in pediatric patients admitted to the toxicology emergency department |
| topic | organophosphate pesticide poisoning toxicity of pesticides pediatric patients biochemical parameters clinical toxicology assessment |
| url | https://www.mdpi.com/2305-6304/10/10/582 |
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