Application of neck ultrasound in the diagnosis of sarcoidosis
Abstract Objective To explore the significance of neck ultrasound (NUS) combined with contrast-enhanced ultrasound (CEUS) in the diagnosis of sarcoidosis. Methods 88 patients with evidence of intrathoracic lymphadenopathy and suspected sarcoidosis with enlarged cervical lymph nodes underwent NUS, CE...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-12-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-021-01769-z |
| _version_ | 1818352517157748736 |
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| author | Mengjun Shen Ying Zhou Weiqing Gu Chengsheng Yin Yin Wang Yuan Zhang |
| author_facet | Mengjun Shen Ying Zhou Weiqing Gu Chengsheng Yin Yin Wang Yuan Zhang |
| author_sort | Mengjun Shen |
| collection | DOAJ |
| description | Abstract Objective To explore the significance of neck ultrasound (NUS) combined with contrast-enhanced ultrasound (CEUS) in the diagnosis of sarcoidosis. Methods 88 patients with evidence of intrathoracic lymphadenopathy and suspected sarcoidosis with enlarged cervical lymph nodes underwent NUS, CEUS, fine-needle aspiration and core needle biopsy when technically feasible were retrospectively analyzed in this study. Seven characteristics such as enhanced mode (EM), resolution time, color Doppler flow imaging (CDFI), fading time, peaking state-uniformity, strengthen the area and symmetry were considered to perform the logistic regression model. Results Of 88 patients included in this study, sarcoidosis was accounted in 20 cases, tuberculosis in 23 cases, malignancy in 22 cases and inflammatory lymph node in 23 cases. There were statistically significant differences in symmetry, lymphatic hilum, homogeneity, CDFI pattern and elasticity score between the sarcoidosis and non-sarcoidosis groups via NUS. Similarly, we also acknowledged a statistically significant differences in EM, homogeneity, presence or absence of necrosis between the sarcoidosis and non-sarcoidosis groups via CEUS to further group the non-sarcoidosis into tuberculosis, malignancy or inflammatory disorder. The percentage correction of prediction was 90% (18/20). Conclusion NUS combined with CEUS has characteristic features in sarcoidosis with cervical lymph node involvement, which is helpful for its diagnosis and differential diagnosis. The binary classification model of NUS combined with CEUS features can help differentiate sarcoidosis from non-sarcoidosis groups. |
| first_indexed | 2024-12-13T18:54:53Z |
| format | Article |
| id | doaj.art-61c739ac202f420fbb913429651edbea |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-13T18:54:53Z |
| publishDate | 2021-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-61c739ac202f420fbb913429651edbea2022-12-21T23:34:50ZengBMCBMC Pulmonary Medicine1471-24662021-12-0121111110.1186/s12890-021-01769-zApplication of neck ultrasound in the diagnosis of sarcoidosisMengjun Shen0Ying Zhou1Weiqing Gu2Chengsheng Yin3Yin Wang4Yuan Zhang5Department of Ultrasound, Shanghai Pulmonary Hospital, School of Medicine, Tongji UniversityDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji UniversityDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji UniversityDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji UniversityDepartment of Ultrasound, Shanghai Pulmonary Hospital, School of Medicine, Tongji UniversityDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji UniversityAbstract Objective To explore the significance of neck ultrasound (NUS) combined with contrast-enhanced ultrasound (CEUS) in the diagnosis of sarcoidosis. Methods 88 patients with evidence of intrathoracic lymphadenopathy and suspected sarcoidosis with enlarged cervical lymph nodes underwent NUS, CEUS, fine-needle aspiration and core needle biopsy when technically feasible were retrospectively analyzed in this study. Seven characteristics such as enhanced mode (EM), resolution time, color Doppler flow imaging (CDFI), fading time, peaking state-uniformity, strengthen the area and symmetry were considered to perform the logistic regression model. Results Of 88 patients included in this study, sarcoidosis was accounted in 20 cases, tuberculosis in 23 cases, malignancy in 22 cases and inflammatory lymph node in 23 cases. There were statistically significant differences in symmetry, lymphatic hilum, homogeneity, CDFI pattern and elasticity score between the sarcoidosis and non-sarcoidosis groups via NUS. Similarly, we also acknowledged a statistically significant differences in EM, homogeneity, presence or absence of necrosis between the sarcoidosis and non-sarcoidosis groups via CEUS to further group the non-sarcoidosis into tuberculosis, malignancy or inflammatory disorder. The percentage correction of prediction was 90% (18/20). Conclusion NUS combined with CEUS has characteristic features in sarcoidosis with cervical lymph node involvement, which is helpful for its diagnosis and differential diagnosis. The binary classification model of NUS combined with CEUS features can help differentiate sarcoidosis from non-sarcoidosis groups.https://doi.org/10.1186/s12890-021-01769-zSarcoidosisCervical lymphadenopathyUltrasoundCEUSTuberculosis |
| spellingShingle | Mengjun Shen Ying Zhou Weiqing Gu Chengsheng Yin Yin Wang Yuan Zhang Application of neck ultrasound in the diagnosis of sarcoidosis BMC Pulmonary Medicine Sarcoidosis Cervical lymphadenopathy Ultrasound CEUS Tuberculosis |
| title | Application of neck ultrasound in the diagnosis of sarcoidosis |
| title_full | Application of neck ultrasound in the diagnosis of sarcoidosis |
| title_fullStr | Application of neck ultrasound in the diagnosis of sarcoidosis |
| title_full_unstemmed | Application of neck ultrasound in the diagnosis of sarcoidosis |
| title_short | Application of neck ultrasound in the diagnosis of sarcoidosis |
| title_sort | application of neck ultrasound in the diagnosis of sarcoidosis |
| topic | Sarcoidosis Cervical lymphadenopathy Ultrasound CEUS Tuberculosis |
| url | https://doi.org/10.1186/s12890-021-01769-z |
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