Development of ASIC1a ligand-gated ion channel drug screening assays across multiple automated patch clamp platforms

Development of ASIC1a ligand-gated ion channel drug screening assays across multiple automated patch clamp platforms

Human acid-sensing ion channels (ASIC) are ligand-gated ionotropic receptors expressed widely in peripheral tissues as well as sensory and central neurons and implicated in detection of inflammation, tissue injury, and hypoxia-induced acidosis. This makes ASIC channels promising targets for drug dis...

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Bibliographic Details
Main Authors: John Ridley, Sam Manyweathers, Raymond Tang, Tom Goetze, Nadine Becker, Ilka Rinke-Weiß, Robert Kirby, Alison Obergrussberger, Marc Rogers
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
automated patch clamp
ligand-gated ionotropic receptor
acid-sensitive ion channel
drug discovery
screening assay
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.982689/full

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