Effect of Lovastatin on Learning and Spatial Memory in Adult Male Rats
Background: Previous studies have shown that statins exert neuroprotective effects. The aim of the present study was to evaluate the effects of lovastatin on learning and memory processes in adult male rats without brain damage. Materials and Methods: In this experimental study, 35 adult male Wistar...
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| Format: | Article |
| Language: | English |
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Bushehr University of Medical Sciences
2018-07-01
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| Series: | Iranian South Medical Journal |
| Subjects: | |
| Online Access: | http://ismj.bpums.ac.ir/browse.php?a_code=A-10-1-50&slc_lang=en&sid=1 |
| _version_ | 1818835063916199936 |
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| author | Azadeh Eskandary Ahmad Ali Moazedi Nastaran Zamani |
| author_facet | Azadeh Eskandary Ahmad Ali Moazedi Nastaran Zamani |
| author_sort | Azadeh Eskandary |
| collection | DOAJ |
| description | Background: Previous studies have shown that statins exert neuroprotective effects. The aim of the present study was to evaluate the effects of lovastatin on learning and memory processes in adult male rats without brain damage.
Materials and Methods: In this experimental study, 35 adult male Wistar rats were randomly divided into 5 groups of 7 rats. Group 1, the control, without any injection; groups 2-4, test groups, each group received lovastatin (1, 10 and 20 mg/kg, IP daily for five days) and group 5, vehicle-treated group received the same volume of DMSO 5% as lovastatin vehicle. At the end of the treatment with lovastatin or vehicle, 8-arm radial maze and Y-maze task were used to evaluate spatial memory.
Results: The results showed that lovastatin (10, 20 mg/kg) reduced reference and working memory errors and the time elapsed in the 8-arm radial maze task in the acquisition test (P˂0.05) and further reduced these functions in retention testing (P˂0.05) compared to the control group. On the Y maze test, alternation percentage showed a significant increase in 20 mg/kg group compared to the control (P˂0.01).
Conclusion: Our results suggest that high doses of lovastatin improve spatial memory although the exact mechanism by which lovastatin affects memory is unclear and requires further investigation.
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| first_indexed | 2024-12-19T02:44:46Z |
| format | Article |
| id | doaj.art-61c8bcd283e74dd6a21e0b91b2949c09 |
| institution | Directory Open Access Journal |
| issn | 1735-4374 1735-6954 |
| language | English |
| last_indexed | 2024-12-19T02:44:46Z |
| publishDate | 2018-07-01 |
| publisher | Bushehr University of Medical Sciences |
| record_format | Article |
| series | Iranian South Medical Journal |
| spelling | doaj.art-61c8bcd283e74dd6a21e0b91b2949c092022-12-21T20:38:57ZengBushehr University of Medical SciencesIranian South Medical Journal1735-43741735-69542018-07-01213197208Effect of Lovastatin on Learning and Spatial Memory in Adult Male RatsAzadeh Eskandary0Ahmad Ali Moazedi1Nastaran Zamani2 Department of Biology, School of Sciences, Shahid Chamran University, Ahvaz, Iran Department of Biology, School of Sciences, Shahid Chamran University, Ahvaz, Iran Department of Biology, School of Sciences, Payamnoor University, Tehran, Iran Background: Previous studies have shown that statins exert neuroprotective effects. The aim of the present study was to evaluate the effects of lovastatin on learning and memory processes in adult male rats without brain damage. Materials and Methods: In this experimental study, 35 adult male Wistar rats were randomly divided into 5 groups of 7 rats. Group 1, the control, without any injection; groups 2-4, test groups, each group received lovastatin (1, 10 and 20 mg/kg, IP daily for five days) and group 5, vehicle-treated group received the same volume of DMSO 5% as lovastatin vehicle. At the end of the treatment with lovastatin or vehicle, 8-arm radial maze and Y-maze task were used to evaluate spatial memory. Results: The results showed that lovastatin (10, 20 mg/kg) reduced reference and working memory errors and the time elapsed in the 8-arm radial maze task in the acquisition test (P˂0.05) and further reduced these functions in retention testing (P˂0.05) compared to the control group. On the Y maze test, alternation percentage showed a significant increase in 20 mg/kg group compared to the control (P˂0.01). Conclusion: Our results suggest that high doses of lovastatin improve spatial memory although the exact mechanism by which lovastatin affects memory is unclear and requires further investigation. http://ismj.bpums.ac.ir/browse.php?a_code=A-10-1-50&slc_lang=en&sid=1Lovastatin Learning Memory Rat |
| spellingShingle | Azadeh Eskandary Ahmad Ali Moazedi Nastaran Zamani Effect of Lovastatin on Learning and Spatial Memory in Adult Male Rats Iranian South Medical Journal Lovastatin Learning Memory Rat |
| title | Effect of Lovastatin on Learning and Spatial Memory in Adult Male Rats |
| title_full | Effect of Lovastatin on Learning and Spatial Memory in Adult Male Rats |
| title_fullStr | Effect of Lovastatin on Learning and Spatial Memory in Adult Male Rats |
| title_full_unstemmed | Effect of Lovastatin on Learning and Spatial Memory in Adult Male Rats |
| title_short | Effect of Lovastatin on Learning and Spatial Memory in Adult Male Rats |
| title_sort | effect of lovastatin on learning and spatial memory in adult male rats |
| topic | Lovastatin Learning Memory Rat |
| url | http://ismj.bpums.ac.ir/browse.php?a_code=A-10-1-50&slc_lang=en&sid=1 |
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