Nomogram for second trimester corpus callosum measurements: are nomograms reliable?

Objective: To define normal values of second trimester fetal corpus callosum (CC) length and width in a low-risk population and to compare the presented nomograms to those in the literature. Methods: The prenatal records of singleton fetuses who underwent second trimester anomaly screening at 18.0–...

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Main Authors: Alemdaroğlu, Songül, Baran, Şafak Yılmaz, Doğan Durdağ, Gülşen, Yüksel Şimşek, Seda, Çoban Şerbetçioğlu, Gonca, Kalaycı, Hakan
Format: Article
Language:English
Published: Perinatal Medicine Foundation 2020-12-01
Series:Perinatal Journal
Online Access:https://perinataljournal.com/Archive/Article/20200283011
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author Alemdaroğlu, Songül
Baran, Şafak Yılmaz
Doğan Durdağ, Gülşen
Yüksel Şimşek, Seda
Çoban Şerbetçioğlu, Gonca
Kalaycı, Hakan
author_facet Alemdaroğlu, Songül
Baran, Şafak Yılmaz
Doğan Durdağ, Gülşen
Yüksel Şimşek, Seda
Çoban Şerbetçioğlu, Gonca
Kalaycı, Hakan
author_sort Alemdaroğlu, Songül
collection DOAJ
description Objective: To define normal values of second trimester fetal corpus callosum (CC) length and width in a low-risk population and to compare the presented nomograms to those in the literature. Methods: The prenatal records of singleton fetuses who underwent second trimester anomaly screening at 18.0–22.0 weeks of pregnancy were retrospectively analyzed for CC width and length. A total of 710 fetuses, whose anomaly scans were completely normal, were included in the study. The correlations between CC and biparietal diameter (BPD), head circumference (HC) and gestational age (GA) were evaluated. Results: At 18.0–22.0 weeks of pregnancy, the mean CC length was 19.7±2.8 mm, while the mean CC thickness was 1.98±0.4 mm. In assessment of the correlations between the CC length and thickness values and the HC, BPD and GA values by Pearson’s correlation coefficient, there was a stronger correlation between the CC length measurements and the BPD, HC and GA values (r=0.233 vs r=0.505, p<0.001). Conclusion: Assessment of the presence of corpus callosum as well as its length and thickness during routine fetal anomaly evaluation may be important owing to the relationship between corpus callosum measurements and certain neurological disorders. Studies indicate that populations should create their own nomograms due to different values reported in the literature.
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spelling doaj.art-61c96114cd8c4c0cb8c74600d64fcc622023-02-15T16:17:44ZengPerinatal Medicine FoundationPerinatal Journal1305-31242020-12-0128319620110.2399/prn.20.0283011Nomogram for second trimester corpus callosum measurements: are nomograms reliable?Alemdaroğlu, SongülBaran, Şafak YılmazDoğan Durdağ, GülşenYüksel Şimşek, SedaÇoban Şerbetçioğlu, GoncaKalaycı, HakanObjective: To define normal values of second trimester fetal corpus callosum (CC) length and width in a low-risk population and to compare the presented nomograms to those in the literature. Methods: The prenatal records of singleton fetuses who underwent second trimester anomaly screening at 18.0–22.0 weeks of pregnancy were retrospectively analyzed for CC width and length. A total of 710 fetuses, whose anomaly scans were completely normal, were included in the study. The correlations between CC and biparietal diameter (BPD), head circumference (HC) and gestational age (GA) were evaluated. Results: At 18.0–22.0 weeks of pregnancy, the mean CC length was 19.7±2.8 mm, while the mean CC thickness was 1.98±0.4 mm. In assessment of the correlations between the CC length and thickness values and the HC, BPD and GA values by Pearson’s correlation coefficient, there was a stronger correlation between the CC length measurements and the BPD, HC and GA values (r=0.233 vs r=0.505, p<0.001). Conclusion: Assessment of the presence of corpus callosum as well as its length and thickness during routine fetal anomaly evaluation may be important owing to the relationship between corpus callosum measurements and certain neurological disorders. Studies indicate that populations should create their own nomograms due to different values reported in the literature.https://perinataljournal.com/Archive/Article/20200283011
spellingShingle Alemdaroğlu, Songül
Baran, Şafak Yılmaz
Doğan Durdağ, Gülşen
Yüksel Şimşek, Seda
Çoban Şerbetçioğlu, Gonca
Kalaycı, Hakan
Nomogram for second trimester corpus callosum measurements: are nomograms reliable?
Perinatal Journal
title Nomogram for second trimester corpus callosum measurements: are nomograms reliable?
title_full Nomogram for second trimester corpus callosum measurements: are nomograms reliable?
title_fullStr Nomogram for second trimester corpus callosum measurements: are nomograms reliable?
title_full_unstemmed Nomogram for second trimester corpus callosum measurements: are nomograms reliable?
title_short Nomogram for second trimester corpus callosum measurements: are nomograms reliable?
title_sort nomogram for second trimester corpus callosum measurements are nomograms reliable
url https://perinataljournal.com/Archive/Article/20200283011
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