Supplementation with Thymbra spicata extract ameliorates lifespan, body-weight gain and Paraquat-induced oxidative stress in Drosophila melanogaster: An age- and sex-related study
Aging represents a decline in function over time. Polyphenols are dietary antioxidants that could exert beneficial effects on aging. This study investigated the effects of dietary supplementation with two extracts from Thymbra spicata L. aerial parts on the lifespan, body-weight control, and antioxi...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S175646462400080X |
| _version_ | 1827329801581494272 |
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| author | Farah Diab Daniela Beghelli Anna Nuccitelli Giulio Lupidi Mohamad Khalil Piero Portincasa Laura Vergani |
| author_facet | Farah Diab Daniela Beghelli Anna Nuccitelli Giulio Lupidi Mohamad Khalil Piero Portincasa Laura Vergani |
| author_sort | Farah Diab |
| collection | DOAJ |
| description | Aging represents a decline in function over time. Polyphenols are dietary antioxidants that could exert beneficial effects on aging. This study investigated the effects of dietary supplementation with two extracts from Thymbra spicata L. aerial parts on the lifespan, body-weight control, and antioxidant responses of Drosophila melanogaster cohorts distinguished for age and sex. The aqueous extract extended the lifespan of young female flies, and this pro-longevity potential was associated with a reduction in the body-weight gain. Furthermore, the aqueous extract promoted the antioxidant defense when young females were exposed to Paraquat by reducing oxidative stress and mortality. This study provides the first insight into the beneficial effects of T. spicata supplementation in an animal model, suggesting that the healthy effect could mainly depend on strengthening the antioxidant defenses which reflect on the lifespan. Further investigations will better clarify the mechanisms and potential of T. spicata as nutraceutics in anti-aging strategies. |
| first_indexed | 2024-03-07T15:47:26Z |
| format | Article |
| id | doaj.art-61c9837945dc41f78eb51709416b83e6 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-07T15:47:26Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-61c9837945dc41f78eb51709416b83e62024-03-05T04:29:38ZengElsevierJournal of Functional Foods1756-46462024-03-01114106078Supplementation with Thymbra spicata extract ameliorates lifespan, body-weight gain and Paraquat-induced oxidative stress in Drosophila melanogaster: An age- and sex-related studyFarah Diab0Daniela Beghelli1Anna Nuccitelli2Giulio Lupidi3Mohamad Khalil4Piero Portincasa5Laura Vergani6Department of Earth, Environment and Life Sciences (DISTAV), University of Genova, 16132 Genova, ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, ItalySchool of Pharmacy, University of Camerino, 62032 Camerino, ItalyClinica Medica “A. Murri”, Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University of Bari Medical School, Bari, ItalyClinica Medica “A. Murri”, Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University of Bari Medical School, Bari, ItalyDepartment of Earth, Environment and Life Sciences (DISTAV), University of Genova, 16132 Genova, Italy; Corresponding author at: Dipartimento di Scienze della Terra, dell’Ambiente e della Vita (DISTAV), Corso Europa 26, 16132 Genova, Italy.Aging represents a decline in function over time. Polyphenols are dietary antioxidants that could exert beneficial effects on aging. This study investigated the effects of dietary supplementation with two extracts from Thymbra spicata L. aerial parts on the lifespan, body-weight control, and antioxidant responses of Drosophila melanogaster cohorts distinguished for age and sex. The aqueous extract extended the lifespan of young female flies, and this pro-longevity potential was associated with a reduction in the body-weight gain. Furthermore, the aqueous extract promoted the antioxidant defense when young females were exposed to Paraquat by reducing oxidative stress and mortality. This study provides the first insight into the beneficial effects of T. spicata supplementation in an animal model, suggesting that the healthy effect could mainly depend on strengthening the antioxidant defenses which reflect on the lifespan. Further investigations will better clarify the mechanisms and potential of T. spicata as nutraceutics in anti-aging strategies.http://www.sciencedirect.com/science/article/pii/S175646462400080XThymbra spicata extractDietary polyphenolsDrosophila melanogasterAgingBody weightAntioxidant defense |
| spellingShingle | Farah Diab Daniela Beghelli Anna Nuccitelli Giulio Lupidi Mohamad Khalil Piero Portincasa Laura Vergani Supplementation with Thymbra spicata extract ameliorates lifespan, body-weight gain and Paraquat-induced oxidative stress in Drosophila melanogaster: An age- and sex-related study Journal of Functional Foods Thymbra spicata extract Dietary polyphenols Drosophila melanogaster Aging Body weight Antioxidant defense |
| title | Supplementation with Thymbra spicata extract ameliorates lifespan, body-weight gain and Paraquat-induced oxidative stress in Drosophila melanogaster: An age- and sex-related study |
| title_full | Supplementation with Thymbra spicata extract ameliorates lifespan, body-weight gain and Paraquat-induced oxidative stress in Drosophila melanogaster: An age- and sex-related study |
| title_fullStr | Supplementation with Thymbra spicata extract ameliorates lifespan, body-weight gain and Paraquat-induced oxidative stress in Drosophila melanogaster: An age- and sex-related study |
| title_full_unstemmed | Supplementation with Thymbra spicata extract ameliorates lifespan, body-weight gain and Paraquat-induced oxidative stress in Drosophila melanogaster: An age- and sex-related study |
| title_short | Supplementation with Thymbra spicata extract ameliorates lifespan, body-weight gain and Paraquat-induced oxidative stress in Drosophila melanogaster: An age- and sex-related study |
| title_sort | supplementation with thymbra spicata extract ameliorates lifespan body weight gain and paraquat induced oxidative stress in drosophila melanogaster an age and sex related study |
| topic | Thymbra spicata extract Dietary polyphenols Drosophila melanogaster Aging Body weight Antioxidant defense |
| url | http://www.sciencedirect.com/science/article/pii/S175646462400080X |
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