An Organic–Inorganic Hybrid Nanocomposite as a Potential New Biological Agent
To solve the problem of human diseases caused by a combination of genetic and environmental factors or by microorganisms, intense research to find completely new materials is required. One of the promising systems in this area is the silver-silica nanocomposites and their derivatives. Hence, silver...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/10/12/2551 |
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| author | Mateusz Dulski Katarzyna Malarz Michał Kuczak Karolina Dudek Krzysztof Matus Sławomir Sułowicz Anna Mrozek-Wilczkiewicz Anna Nowak |
| author_facet | Mateusz Dulski Katarzyna Malarz Michał Kuczak Karolina Dudek Krzysztof Matus Sławomir Sułowicz Anna Mrozek-Wilczkiewicz Anna Nowak |
| author_sort | Mateusz Dulski |
| collection | DOAJ |
| description | To solve the problem of human diseases caused by a combination of genetic and environmental factors or by microorganisms, intense research to find completely new materials is required. One of the promising systems in this area is the silver-silica nanocomposites and their derivatives. Hence, silver and silver oxide nanoparticles that were homogeneously distributed within a silica carrier were fabricated. Their average size was d = (7.8 ± 0.3) nm. The organic polymers (carboxymethylcellulose (CMC) and sodium alginate (AS)) were added to improve the biological features of the nanocomposite. The first system was prepared as a silver chlorine salt combination that was immersed on a silica carrier with coagulated particles whose size was d = (44.1 ± 2.3) nm, which coexisted with metallic silver. The second system obtained was synergistically interacted metallic and oxidized silver nanoparticles that were distributed on a structurally defective silica network. Their average size was d = (6.6 ± 0.7) nm. Physicochemical and biological experiments showed that the tiny silver nanoparticles in Ag/SiO<sub>2</sub> and Ag/SiO<sub>2</sub>@AS inhibited <i>E. coli</i>, <i>P. aeruginosa</i>, <i>S. aureus</i>, and <i>L. plantarum’s</i> cell growth as well as caused a high anticancer effect. On the other hand, the massive silver nanoparticles of Ag/SiO<sub>2</sub>@CMC had a weaker antimicrobial effect, although they highly interacted against PANC-1. They also generated reactive oxygen species (ROS) as well as the induction of apoptosis via the p53-independent mechanism. |
| first_indexed | 2024-03-10T13:56:10Z |
| format | Article |
| id | doaj.art-61caafbd424b4b98b76b550083188cfa |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T13:56:10Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-61caafbd424b4b98b76b550083188cfa2023-11-21T01:34:57ZengMDPI AGNanomaterials2079-49912020-12-011012255110.3390/nano10122551An Organic–Inorganic Hybrid Nanocomposite as a Potential New Biological AgentMateusz Dulski0Katarzyna Malarz1Michał Kuczak2Karolina Dudek3Krzysztof Matus4Sławomir Sułowicz5Anna Mrozek-Wilczkiewicz6Anna Nowak7Institute of Materials Engineering, University of Silesia, 75 Pulku Piechoty 1a, 41-500 Chorzow, PolandSilesian Center for Education and Interdisciplinary Research, 75 Pulku Piechoty 1a, 41-500 Chorzow, PolandSilesian Center for Education and Interdisciplinary Research, 75 Pulku Piechoty 1a, 41-500 Chorzow, PolandŁukasiewicz Research Network - Institute of Ceramics and Building Materials, Refractory Materials Division in Gliwice, Toszecka 99, 44-100 Gliwice, PolandMaterials Research Laboratory, Silesian University of Technology, Konarskiego 18a, 44-100 Gliwice, PolandInstitute of Biology, Biotechnology and Environmental Protection, University of Silesia, Jagiellonska 28, 40-032 Katowice, PolandSilesian Center for Education and Interdisciplinary Research, 75 Pulku Piechoty 1a, 41-500 Chorzow, PolandInstitute of Nuclear Physics Polish Academy of Sciences, PL-31342 Krakow, PolandTo solve the problem of human diseases caused by a combination of genetic and environmental factors or by microorganisms, intense research to find completely new materials is required. One of the promising systems in this area is the silver-silica nanocomposites and their derivatives. Hence, silver and silver oxide nanoparticles that were homogeneously distributed within a silica carrier were fabricated. Their average size was d = (7.8 ± 0.3) nm. The organic polymers (carboxymethylcellulose (CMC) and sodium alginate (AS)) were added to improve the biological features of the nanocomposite. The first system was prepared as a silver chlorine salt combination that was immersed on a silica carrier with coagulated particles whose size was d = (44.1 ± 2.3) nm, which coexisted with metallic silver. The second system obtained was synergistically interacted metallic and oxidized silver nanoparticles that were distributed on a structurally defective silica network. Their average size was d = (6.6 ± 0.7) nm. Physicochemical and biological experiments showed that the tiny silver nanoparticles in Ag/SiO<sub>2</sub> and Ag/SiO<sub>2</sub>@AS inhibited <i>E. coli</i>, <i>P. aeruginosa</i>, <i>S. aureus</i>, and <i>L. plantarum’s</i> cell growth as well as caused a high anticancer effect. On the other hand, the massive silver nanoparticles of Ag/SiO<sub>2</sub>@CMC had a weaker antimicrobial effect, although they highly interacted against PANC-1. They also generated reactive oxygen species (ROS) as well as the induction of apoptosis via the p53-independent mechanism.https://www.mdpi.com/2079-4991/10/12/2551chemical reductionsilver-silica nanocompositecarboxymethylcellulosesodium alginatephysicochemical featuresantimicrobial activity |
| spellingShingle | Mateusz Dulski Katarzyna Malarz Michał Kuczak Karolina Dudek Krzysztof Matus Sławomir Sułowicz Anna Mrozek-Wilczkiewicz Anna Nowak An Organic–Inorganic Hybrid Nanocomposite as a Potential New Biological Agent Nanomaterials chemical reduction silver-silica nanocomposite carboxymethylcellulose sodium alginate physicochemical features antimicrobial activity |
| title | An Organic–Inorganic Hybrid Nanocomposite as a Potential New Biological Agent |
| title_full | An Organic–Inorganic Hybrid Nanocomposite as a Potential New Biological Agent |
| title_fullStr | An Organic–Inorganic Hybrid Nanocomposite as a Potential New Biological Agent |
| title_full_unstemmed | An Organic–Inorganic Hybrid Nanocomposite as a Potential New Biological Agent |
| title_short | An Organic–Inorganic Hybrid Nanocomposite as a Potential New Biological Agent |
| title_sort | organic inorganic hybrid nanocomposite as a potential new biological agent |
| topic | chemical reduction silver-silica nanocomposite carboxymethylcellulose sodium alginate physicochemical features antimicrobial activity |
| url | https://www.mdpi.com/2079-4991/10/12/2551 |
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