MGluR5 mediates the interaction between late-LTP, network activity, and learning.
Hippocampal synaptic plasticity and learning are strongly regulated by metabotropic glutamate receptors (mGluRs) and particularly by mGluR5. Here, we investigated the mechanisms underlying mGluR5-modulation of these phenomena. Prolonged pharmacological blockade of mGluR5 with MPEP produced a profoun...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2008-05-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2364645?pdf=render |
| _version_ | 1819062521070354432 |
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| author | Arthur Bikbaev Sergey Neyman Richard Teke Ngomba P Jeffrey Conn Ferdinando Nicoletti Denise Manahan-Vaughan |
| author_facet | Arthur Bikbaev Sergey Neyman Richard Teke Ngomba P Jeffrey Conn Ferdinando Nicoletti Denise Manahan-Vaughan |
| author_sort | Arthur Bikbaev |
| collection | DOAJ |
| description | Hippocampal synaptic plasticity and learning are strongly regulated by metabotropic glutamate receptors (mGluRs) and particularly by mGluR5. Here, we investigated the mechanisms underlying mGluR5-modulation of these phenomena. Prolonged pharmacological blockade of mGluR5 with MPEP produced a profound impairment of spatial memory. Effects were associated with 1) a reduction of mGluR1a-expression in the dentate gyrus; 2) impaired dentate gyrus LTP; 3) enhanced CA1-LTP and 4) suppressed theta (5-10 Hz) and gamma (30-100 Hz) oscillations in the dentate gyrus. Allosteric potentiation of mGluR1 after mGluR5 blockade significantly ameliorated dentate gyrus LTP, as well as suppression of gamma oscillatory activity. CA3-lesioning prevented MPEP effects on CA1-LTP, suggesting that plasticity levels in CA1 are driven by mGluR5-dependent synaptic and network activity in the dentate gyrus. These data support the hypothesis that prolonged mGluR5-inactivation causes altered hippocampal LTP levels and network activity, which is mediated in part by impaired mGluR1-expression in the dentate gyrus. The consequence is impairment of long-term learning. |
| first_indexed | 2024-12-21T15:00:06Z |
| format | Article |
| id | doaj.art-61cad06c517f4eaa91878c406480bb4c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T15:00:06Z |
| publishDate | 2008-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-61cad06c517f4eaa91878c406480bb4c2022-12-21T18:59:36ZengPublic Library of Science (PLoS)PLoS ONE1932-62032008-05-0135e215510.1371/journal.pone.0002155MGluR5 mediates the interaction between late-LTP, network activity, and learning.Arthur BikbaevSergey NeymanRichard Teke NgombaP Jeffrey ConnFerdinando NicolettiDenise Manahan-VaughanHippocampal synaptic plasticity and learning are strongly regulated by metabotropic glutamate receptors (mGluRs) and particularly by mGluR5. Here, we investigated the mechanisms underlying mGluR5-modulation of these phenomena. Prolonged pharmacological blockade of mGluR5 with MPEP produced a profound impairment of spatial memory. Effects were associated with 1) a reduction of mGluR1a-expression in the dentate gyrus; 2) impaired dentate gyrus LTP; 3) enhanced CA1-LTP and 4) suppressed theta (5-10 Hz) and gamma (30-100 Hz) oscillations in the dentate gyrus. Allosteric potentiation of mGluR1 after mGluR5 blockade significantly ameliorated dentate gyrus LTP, as well as suppression of gamma oscillatory activity. CA3-lesioning prevented MPEP effects on CA1-LTP, suggesting that plasticity levels in CA1 are driven by mGluR5-dependent synaptic and network activity in the dentate gyrus. These data support the hypothesis that prolonged mGluR5-inactivation causes altered hippocampal LTP levels and network activity, which is mediated in part by impaired mGluR1-expression in the dentate gyrus. The consequence is impairment of long-term learning.http://europepmc.org/articles/PMC2364645?pdf=render |
| spellingShingle | Arthur Bikbaev Sergey Neyman Richard Teke Ngomba P Jeffrey Conn Ferdinando Nicoletti Denise Manahan-Vaughan MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE |
| title | MGluR5 mediates the interaction between late-LTP, network activity, and learning. |
| title_full | MGluR5 mediates the interaction between late-LTP, network activity, and learning. |
| title_fullStr | MGluR5 mediates the interaction between late-LTP, network activity, and learning. |
| title_full_unstemmed | MGluR5 mediates the interaction between late-LTP, network activity, and learning. |
| title_short | MGluR5 mediates the interaction between late-LTP, network activity, and learning. |
| title_sort | mglur5 mediates the interaction between late ltp network activity and learning |
| url | http://europepmc.org/articles/PMC2364645?pdf=render |
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