MGluR5 mediates the interaction between late-LTP, network activity, and learning.

MGluR5 mediates the interaction between late-LTP, network activity, and learning.

Hippocampal synaptic plasticity and learning are strongly regulated by metabotropic glutamate receptors (mGluRs) and particularly by mGluR5. Here, we investigated the mechanisms underlying mGluR5-modulation of these phenomena. Prolonged pharmacological blockade of mGluR5 with MPEP produced a profoun...

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Bibliographic Details
Main Authors:	Arthur Bikbaev, Sergey Neyman, Richard Teke Ngomba, P Jeffrey Conn, Ferdinando Nicoletti, Denise Manahan-Vaughan
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2008-05-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC2364645?pdf=render

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