Proposed Update to the Taxonomy of Pestiviruses: Eight Additional Species within the Genus <i>Pestivirus</i>, Family <i>Flaviviridae</i>
Pestiviruses are plus-stranded RNA viruses belonging to the family <i>Flaviviridae.</i> They comprise several important pathogens like classical swine fever virus and bovine viral diarrhea virus that induce economically important animal diseases. In 2017, the last update of pestivirus ta...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/8/1542 |
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| author | Alexander Postel Donald B. Smith Paul Becher |
| author_facet | Alexander Postel Donald B. Smith Paul Becher |
| author_sort | Alexander Postel |
| collection | DOAJ |
| description | Pestiviruses are plus-stranded RNA viruses belonging to the family <i>Flaviviridae.</i> They comprise several important pathogens like classical swine fever virus and bovine viral diarrhea virus that induce economically important animal diseases. In 2017, the last update of pestivirus taxonomy resulted in demarcation of 11 species designated <i>Pestivirus</i> <i>A</i> through <i>Pestivirus K</i>. Since then, multiple new pestiviruses have been reported including pathogens associated with disease in pigs or small ruminants. In addition, pestivirus sequences have been found during metagenomics analysis of different non-ungulate hosts (bats, rodents, whale, and pangolin), but the consequences of this pestivirus diversity for animal health still need to be established. To provide a systematic classification of the newly discovered viruses, we analyzed the genetic relationship based on complete coding sequences (cds) and deduced polyprotein sequences and calculated pairwise distances that allow species demarcation. In addition, phylogenetic analysis was performed based on a highly conserved region within the non-structural protein NS5B. Taking into account the genetic relationships observed together with available information about antigenic properties, host origin, and characteristics of disease, we propose to expand the number of pestivirus species to 19 by adding eight additional species designated <i>Pestivirus</i> <i>L</i> through <i>Pestivirus</i> <i>S</i>. |
| first_indexed | 2024-03-10T08:18:34Z |
| format | Article |
| id | doaj.art-61cb8f07d0154afaa93dd19c0c22dbf0 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T08:18:34Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-61cb8f07d0154afaa93dd19c0c22dbf02023-11-22T10:11:01ZengMDPI AGViruses1999-49152021-08-01138154210.3390/v13081542Proposed Update to the Taxonomy of Pestiviruses: Eight Additional Species within the Genus <i>Pestivirus</i>, Family <i>Flaviviridae</i>Alexander Postel0Donald B. Smith1Paul Becher2Institute of Virology, University of Veterinary Medicine, 30559 Hannover, GermanyNuffield Department of Experimental Medicine, University of Oxford, Peter Medawar Building, South Parks Road, Oxford OX1 3SY, UKInstitute of Virology, University of Veterinary Medicine, 30559 Hannover, GermanyPestiviruses are plus-stranded RNA viruses belonging to the family <i>Flaviviridae.</i> They comprise several important pathogens like classical swine fever virus and bovine viral diarrhea virus that induce economically important animal diseases. In 2017, the last update of pestivirus taxonomy resulted in demarcation of 11 species designated <i>Pestivirus</i> <i>A</i> through <i>Pestivirus K</i>. Since then, multiple new pestiviruses have been reported including pathogens associated with disease in pigs or small ruminants. In addition, pestivirus sequences have been found during metagenomics analysis of different non-ungulate hosts (bats, rodents, whale, and pangolin), but the consequences of this pestivirus diversity for animal health still need to be established. To provide a systematic classification of the newly discovered viruses, we analyzed the genetic relationship based on complete coding sequences (cds) and deduced polyprotein sequences and calculated pairwise distances that allow species demarcation. In addition, phylogenetic analysis was performed based on a highly conserved region within the non-structural protein NS5B. Taking into account the genetic relationships observed together with available information about antigenic properties, host origin, and characteristics of disease, we propose to expand the number of pestivirus species to 19 by adding eight additional species designated <i>Pestivirus</i> <i>L</i> through <i>Pestivirus</i> <i>S</i>.https://www.mdpi.com/1999-4915/13/8/1542<i>Flaviviridae</i>pestivirustaxonomyspeciesgenetic distancesphylogenetic analysis |
| spellingShingle | Alexander Postel Donald B. Smith Paul Becher Proposed Update to the Taxonomy of Pestiviruses: Eight Additional Species within the Genus <i>Pestivirus</i>, Family <i>Flaviviridae</i> Viruses <i>Flaviviridae</i> pestivirus taxonomy species genetic distances phylogenetic analysis |
| title | Proposed Update to the Taxonomy of Pestiviruses: Eight Additional Species within the Genus <i>Pestivirus</i>, Family <i>Flaviviridae</i> |
| title_full | Proposed Update to the Taxonomy of Pestiviruses: Eight Additional Species within the Genus <i>Pestivirus</i>, Family <i>Flaviviridae</i> |
| title_fullStr | Proposed Update to the Taxonomy of Pestiviruses: Eight Additional Species within the Genus <i>Pestivirus</i>, Family <i>Flaviviridae</i> |
| title_full_unstemmed | Proposed Update to the Taxonomy of Pestiviruses: Eight Additional Species within the Genus <i>Pestivirus</i>, Family <i>Flaviviridae</i> |
| title_short | Proposed Update to the Taxonomy of Pestiviruses: Eight Additional Species within the Genus <i>Pestivirus</i>, Family <i>Flaviviridae</i> |
| title_sort | proposed update to the taxonomy of pestiviruses eight additional species within the genus i pestivirus i family i flaviviridae i |
| topic | <i>Flaviviridae</i> pestivirus taxonomy species genetic distances phylogenetic analysis |
| url | https://www.mdpi.com/1999-4915/13/8/1542 |
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