A Review on the Pathogenesis and Clinical Management of Placental Site Trophoblastic Tumors
Placental site trophoblastic tumor (PSTT) is a rare type of gestational trophoblastic disease originating from the intermediate trophoblast. Compared with hydatidiform mole, invasive hydatidiform mole and choriocarcinoma, the diagnosis of PSTT is more complicated and lacks specific and sensitive tum...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2019.00937/full |
| _version_ | 1818152860929490944 |
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| author | Xuan Feng Xuan Feng Xuan Feng Zhi Wei Zhi Wei Zhi Wei Sai Zhang Sai Zhang Sai Zhang Yan Du Yan Du Yan Du Hongbo Zhao Hongbo Zhao Hongbo Zhao |
| author_facet | Xuan Feng Xuan Feng Xuan Feng Zhi Wei Zhi Wei Zhi Wei Sai Zhang Sai Zhang Sai Zhang Yan Du Yan Du Yan Du Hongbo Zhao Hongbo Zhao Hongbo Zhao |
| author_sort | Xuan Feng |
| collection | DOAJ |
| description | Placental site trophoblastic tumor (PSTT) is a rare type of gestational trophoblastic disease originating from the intermediate trophoblast. Compared with hydatidiform mole, invasive hydatidiform mole and choriocarcinoma, the diagnosis of PSTT is more complicated and lacks specific and sensitive tumor markers. Most PSTT patients demonstrate malignant potential, and the primary treatment of PSTT is hysterectomy. However, metastasis occasionally occurs and even causes death in a small number of PSTT patients. Most PSTT patients are young women hence fertility preservation is an important consideration. The major obstacle for PSTT patient prognosis is chemotherapy resistance. However, the current understanding of the pathogenesis of PSTT and clinical treatment remains elusive. In this review, we summarized the research progress of PSTT in recent years from three aspects: mechanism, clinical presentation, and treatment and prognosis. Well-conducted multi-center studies with sufficient sample sizes are of great importance to better examine the pathological progress and evaluate the prognosis of PSTT patients, so as to develop prevention and early detection programs, as well as novel treatment strategies, and finally improve prognosis for PSTT patients. |
| first_indexed | 2024-12-11T14:01:26Z |
| format | Article |
| id | doaj.art-61cec24802c5474fa476ac108db5195b |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-11T14:01:26Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-61cec24802c5474fa476ac108db5195b2022-12-22T01:03:50ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2019-11-01910.3389/fonc.2019.00937473323A Review on the Pathogenesis and Clinical Management of Placental Site Trophoblastic TumorsXuan Feng0Xuan Feng1Xuan Feng2Zhi Wei3Zhi Wei4Zhi Wei5Sai Zhang6Sai Zhang7Sai Zhang8Yan Du9Yan Du10Yan Du11Hongbo Zhao12Hongbo Zhao13Hongbo Zhao14Obstetrics and Gynecology Hospital, Fudan University, Shanghai, ChinaDepartment of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai, ChinaShanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, ChinaObstetrics and Gynecology Hospital, Fudan University, Shanghai, ChinaDepartment of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai, ChinaShanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, ChinaObstetrics and Gynecology Hospital, Fudan University, Shanghai, ChinaDepartment of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai, ChinaShanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, ChinaObstetrics and Gynecology Hospital, Fudan University, Shanghai, ChinaDepartment of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai, ChinaShanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, ChinaObstetrics and Gynecology Hospital, Fudan University, Shanghai, ChinaDepartment of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai, ChinaShanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, ChinaPlacental site trophoblastic tumor (PSTT) is a rare type of gestational trophoblastic disease originating from the intermediate trophoblast. Compared with hydatidiform mole, invasive hydatidiform mole and choriocarcinoma, the diagnosis of PSTT is more complicated and lacks specific and sensitive tumor markers. Most PSTT patients demonstrate malignant potential, and the primary treatment of PSTT is hysterectomy. However, metastasis occasionally occurs and even causes death in a small number of PSTT patients. Most PSTT patients are young women hence fertility preservation is an important consideration. The major obstacle for PSTT patient prognosis is chemotherapy resistance. However, the current understanding of the pathogenesis of PSTT and clinical treatment remains elusive. In this review, we summarized the research progress of PSTT in recent years from three aspects: mechanism, clinical presentation, and treatment and prognosis. Well-conducted multi-center studies with sufficient sample sizes are of great importance to better examine the pathological progress and evaluate the prognosis of PSTT patients, so as to develop prevention and early detection programs, as well as novel treatment strategies, and finally improve prognosis for PSTT patients.https://www.frontiersin.org/article/10.3389/fonc.2019.00937/fullplacenta site trophoblastic tumorclinical presentationmechanismtreatmentprognosis |
| spellingShingle | Xuan Feng Xuan Feng Xuan Feng Zhi Wei Zhi Wei Zhi Wei Sai Zhang Sai Zhang Sai Zhang Yan Du Yan Du Yan Du Hongbo Zhao Hongbo Zhao Hongbo Zhao A Review on the Pathogenesis and Clinical Management of Placental Site Trophoblastic Tumors Frontiers in Oncology placenta site trophoblastic tumor clinical presentation mechanism treatment prognosis |
| title | A Review on the Pathogenesis and Clinical Management of Placental Site Trophoblastic Tumors |
| title_full | A Review on the Pathogenesis and Clinical Management of Placental Site Trophoblastic Tumors |
| title_fullStr | A Review on the Pathogenesis and Clinical Management of Placental Site Trophoblastic Tumors |
| title_full_unstemmed | A Review on the Pathogenesis and Clinical Management of Placental Site Trophoblastic Tumors |
| title_short | A Review on the Pathogenesis and Clinical Management of Placental Site Trophoblastic Tumors |
| title_sort | review on the pathogenesis and clinical management of placental site trophoblastic tumors |
| topic | placenta site trophoblastic tumor clinical presentation mechanism treatment prognosis |
| url | https://www.frontiersin.org/article/10.3389/fonc.2019.00937/full |
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