Epigenetic inactivation of HOXD10 is associated with human colon cancer via inhibiting the RHOC/AKT/MAPK signaling pathway

Epigenetic inactivation of HOXD10 is associated with human colon cancer via inhibiting the RHOC/AKT/MAPK signaling pathway

Abstract Background To examine the influence of HOXD10 on the metabolism and growth of colon carcinoma cells by suppressing the RHOC/AKT/MAPK pathway. Methods Thirty-seven paired colon cancer and its adjacent samples from The Cancer Genome Atlas (TCGA) were analyzed. Chip Analysis Methylation Pipeli...

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Bibliographic Details
Main Authors: Yu-hong Yuan, Han-yu Wang, Yu Lai, Wa Zhong, Wei-ling Liang, Fu-de Yan, Zhong Yu, Jun-kai Chen, Ying Lin
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Cell Communication and Signaling
Subjects:
Colon cancer
Methylation
5-Aza-dC
HOXD10
RHOC/AKT/MAPK pathway
Online Access:http://link.springer.com/article/10.1186/s12964-018-0316-0

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