Functional analysis of Hsp70 inhibitors.
The molecular chaperones of the Hsp70 family have been recognized as targets for anti-cancer therapy. Since several paralogs of Hsp70 proteins exist in cytosol, endoplasmic reticulum and mitochondria, we investigated which isoform needs to be down-regulated for reducing viability of cancer cells. Fo...
Main Authors: | Rainer Schlecht, Sebastian R Scholz, Heike Dahmen, Ansgar Wegener, Christian Sirrenberg, Djordje Musil, Joerg Bomke, Hans-Michael Eggenweiler, Matthias P Mayer, Bernd Bukau |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24265689/?tool=EBI |
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