Shared features of cryptic plasmids from environmental and pathogenic Francisella species.
The Francisella genus includes several recognized species, additional potential species, and other representatives that inhabit a range of incredibly diverse ecological niches, but are not closely related to the named species. Francisella species have been obtained from a wide variety of clinical an...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5570271?pdf=render |
| _version_ | 1819062742808526848 |
|---|---|
| author | Jean F Challacombe Segaran Pillai Cheryl R Kuske |
| author_facet | Jean F Challacombe Segaran Pillai Cheryl R Kuske |
| author_sort | Jean F Challacombe |
| collection | DOAJ |
| description | The Francisella genus includes several recognized species, additional potential species, and other representatives that inhabit a range of incredibly diverse ecological niches, but are not closely related to the named species. Francisella species have been obtained from a wide variety of clinical and environmental sources; documented species include highly virulent human and animal pathogens, fish pathogens, opportunistic human pathogens, tick endosymbionts, and free-living isolates inhabiting brackish water. While more than 120 Francisella genomes have been sequenced to date, only a few contain plasmids, and most of these appear to be cryptic, with unknown benefit to the host cell. We have identified several putative cryptic plasmids in the sequenced genomes of three Francisella novicida and F. novicida-like strains (TX07-6608, AZ06-7470, DPG_3A-IS) and two new Francisella species (F. frigiditurris CA97-1460 and F. opportunistica MA06-7296). These plasmids were compared to each other and to previously identified plasmids from other Francisella species. Some of the plasmids encoded functions potentially involved in replication, conjugal transfer and partitioning, environmental survival (transcriptional regulation, signaling, metabolism), and hypothetical proteins with no assignable functions. Genomic and phylogenetic comparisons of these new plasmids to the other known Francisella plasmids revealed some similarities that add to our understanding of the evolutionary relationships among the diverse Francisella species. |
| first_indexed | 2024-12-21T15:03:37Z |
| format | Article |
| id | doaj.art-61d375a31f674bd8b44d82ead9198f11 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T15:03:37Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-61d375a31f674bd8b44d82ead9198f112022-12-21T18:59:32ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01128e018355410.1371/journal.pone.0183554Shared features of cryptic plasmids from environmental and pathogenic Francisella species.Jean F ChallacombeSegaran PillaiCheryl R KuskeThe Francisella genus includes several recognized species, additional potential species, and other representatives that inhabit a range of incredibly diverse ecological niches, but are not closely related to the named species. Francisella species have been obtained from a wide variety of clinical and environmental sources; documented species include highly virulent human and animal pathogens, fish pathogens, opportunistic human pathogens, tick endosymbionts, and free-living isolates inhabiting brackish water. While more than 120 Francisella genomes have been sequenced to date, only a few contain plasmids, and most of these appear to be cryptic, with unknown benefit to the host cell. We have identified several putative cryptic plasmids in the sequenced genomes of three Francisella novicida and F. novicida-like strains (TX07-6608, AZ06-7470, DPG_3A-IS) and two new Francisella species (F. frigiditurris CA97-1460 and F. opportunistica MA06-7296). These plasmids were compared to each other and to previously identified plasmids from other Francisella species. Some of the plasmids encoded functions potentially involved in replication, conjugal transfer and partitioning, environmental survival (transcriptional regulation, signaling, metabolism), and hypothetical proteins with no assignable functions. Genomic and phylogenetic comparisons of these new plasmids to the other known Francisella plasmids revealed some similarities that add to our understanding of the evolutionary relationships among the diverse Francisella species.http://europepmc.org/articles/PMC5570271?pdf=render |
| spellingShingle | Jean F Challacombe Segaran Pillai Cheryl R Kuske Shared features of cryptic plasmids from environmental and pathogenic Francisella species. PLoS ONE |
| title | Shared features of cryptic plasmids from environmental and pathogenic Francisella species. |
| title_full | Shared features of cryptic plasmids from environmental and pathogenic Francisella species. |
| title_fullStr | Shared features of cryptic plasmids from environmental and pathogenic Francisella species. |
| title_full_unstemmed | Shared features of cryptic plasmids from environmental and pathogenic Francisella species. |
| title_short | Shared features of cryptic plasmids from environmental and pathogenic Francisella species. |
| title_sort | shared features of cryptic plasmids from environmental and pathogenic francisella species |
| url | http://europepmc.org/articles/PMC5570271?pdf=render |
| work_keys_str_mv | AT jeanfchallacombe sharedfeaturesofcrypticplasmidsfromenvironmentalandpathogenicfrancisellaspecies AT segaranpillai sharedfeaturesofcrypticplasmidsfromenvironmentalandpathogenicfrancisellaspecies AT cherylrkuske sharedfeaturesofcrypticplasmidsfromenvironmentalandpathogenicfrancisellaspecies |