Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia
Abstract Abnormalities in prenatal brain development contribute to schizophrenia vulnerability. Orbitofrontal cortex sulcogyral patterns are largely determined during prenatal development, and four types of orbitofrontal cortex sulcogyral patterns have been classified in humans. Altered orbitofronta...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-01-01
|
| Series: | npj Schizophrenia |
| Online Access: | https://doi.org/10.1038/s41537-016-0008-y |
| _version_ | 1797428735201247232 |
|---|---|
| author | Shuichi Isomura Ryota Hashimoto Motoaki Nakamura Yoji Hirano Fumio Yamashita Shin Jimbo Hidenaga Yamamori Michiko Fujimoto Yuka Yasuda Ryan P. Mears Toshiaki Onitsuka |
| author_facet | Shuichi Isomura Ryota Hashimoto Motoaki Nakamura Yoji Hirano Fumio Yamashita Shin Jimbo Hidenaga Yamamori Michiko Fujimoto Yuka Yasuda Ryan P. Mears Toshiaki Onitsuka |
| author_sort | Shuichi Isomura |
| collection | DOAJ |
| description | Abstract Abnormalities in prenatal brain development contribute to schizophrenia vulnerability. Orbitofrontal cortex sulcogyral patterns are largely determined during prenatal development, and four types of orbitofrontal cortex sulcogyral patterns have been classified in humans. Altered orbitofrontal cortex patterns have been reported in individuals with schizophrenia using magnetic resonance imaging; however, sample sizes of previous studies were small–medium effects for detection, and gender manifestation for orbitofrontal cortex sulcogyral patterns is unclear. The present study investigated orbitofrontal cortex patterns of 155 patients with schizophrenia and 375 healthy subjects. The orbitofrontal cortex sulcogyral pattern distributions of schizophrenia were significantly different compared with healthy subjects in the left hemisphere (χ 2 = 14.55, p = 0.002). In female schizophrenia, post-hoc analyses revealed significantly decreased Type I expression (χ 2 = 6.76, p = 0.009) and increased Type II expression (χ 2 = 11.56, p = 0.001) in the left hemisphere. The present study suggested that female schizophrenia showed altered orbitofrontal cortex patterns in the left hemisphere, which may be related to neurodevelopmental abnormality. |
| first_indexed | 2024-03-09T09:03:10Z |
| format | Article |
| id | doaj.art-61d45068fca742eca20fceb0c02788be |
| institution | Directory Open Access Journal |
| issn | 2334-265X |
| language | English |
| last_indexed | 2024-03-09T09:03:10Z |
| publishDate | 2017-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Schizophrenia |
| spelling | doaj.art-61d45068fca742eca20fceb0c02788be2023-12-02T11:12:45ZengNature Portfolionpj Schizophrenia2334-265X2017-01-01311410.1038/s41537-016-0008-yAltered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophreniaShuichi Isomura0Ryota Hashimoto1Motoaki Nakamura2Yoji Hirano3Fumio Yamashita4Shin Jimbo5Hidenaga Yamamori6Michiko Fujimoto7Yuka Yasuda8Ryan P. Mears9Toshiaki Onitsuka10Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu UniversityMolecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka UniversityKanagawa Psychiatric CenterDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu UniversityDivision of Ultra-high Field MRI, Institute for Biomedical Sciences, Iwate Medical UniversityDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu UniversityDepartment of Psychiatry, Osaka University Graduate School of MedicineDepartment of Psychiatry, Osaka University Graduate School of MedicineDepartment of Psychiatry, Osaka University Graduate School of MedicineDepartment of Psychology, University of FloridaDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu UniversityAbstract Abnormalities in prenatal brain development contribute to schizophrenia vulnerability. Orbitofrontal cortex sulcogyral patterns are largely determined during prenatal development, and four types of orbitofrontal cortex sulcogyral patterns have been classified in humans. Altered orbitofrontal cortex patterns have been reported in individuals with schizophrenia using magnetic resonance imaging; however, sample sizes of previous studies were small–medium effects for detection, and gender manifestation for orbitofrontal cortex sulcogyral patterns is unclear. The present study investigated orbitofrontal cortex patterns of 155 patients with schizophrenia and 375 healthy subjects. The orbitofrontal cortex sulcogyral pattern distributions of schizophrenia were significantly different compared with healthy subjects in the left hemisphere (χ 2 = 14.55, p = 0.002). In female schizophrenia, post-hoc analyses revealed significantly decreased Type I expression (χ 2 = 6.76, p = 0.009) and increased Type II expression (χ 2 = 11.56, p = 0.001) in the left hemisphere. The present study suggested that female schizophrenia showed altered orbitofrontal cortex patterns in the left hemisphere, which may be related to neurodevelopmental abnormality.https://doi.org/10.1038/s41537-016-0008-y |
| spellingShingle | Shuichi Isomura Ryota Hashimoto Motoaki Nakamura Yoji Hirano Fumio Yamashita Shin Jimbo Hidenaga Yamamori Michiko Fujimoto Yuka Yasuda Ryan P. Mears Toshiaki Onitsuka Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia npj Schizophrenia |
| title | Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia |
| title_full | Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia |
| title_fullStr | Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia |
| title_full_unstemmed | Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia |
| title_short | Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia |
| title_sort | altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia |
| url | https://doi.org/10.1038/s41537-016-0008-y |
| work_keys_str_mv | AT shuichiisomura alteredsulcogyralpatternsoforbitofrontalcortexinalargecohortofpatientswithschizophrenia AT ryotahashimoto alteredsulcogyralpatternsoforbitofrontalcortexinalargecohortofpatientswithschizophrenia AT motoakinakamura alteredsulcogyralpatternsoforbitofrontalcortexinalargecohortofpatientswithschizophrenia AT yojihirano alteredsulcogyralpatternsoforbitofrontalcortexinalargecohortofpatientswithschizophrenia AT fumioyamashita alteredsulcogyralpatternsoforbitofrontalcortexinalargecohortofpatientswithschizophrenia AT shinjimbo alteredsulcogyralpatternsoforbitofrontalcortexinalargecohortofpatientswithschizophrenia AT hidenagayamamori alteredsulcogyralpatternsoforbitofrontalcortexinalargecohortofpatientswithschizophrenia AT michikofujimoto alteredsulcogyralpatternsoforbitofrontalcortexinalargecohortofpatientswithschizophrenia AT yukayasuda alteredsulcogyralpatternsoforbitofrontalcortexinalargecohortofpatientswithschizophrenia AT ryanpmears alteredsulcogyralpatternsoforbitofrontalcortexinalargecohortofpatientswithschizophrenia AT toshiakionitsuka alteredsulcogyralpatternsoforbitofrontalcortexinalargecohortofpatientswithschizophrenia |