Lower levels of uric acid and striatal dopamine in non-tremor dominant Parkinson's disease subtype.
Parkinson's disease (PD) patients who present with tremor and maintain a predominance of tremor have a better prognosis. Similarly, PD patients with high levels of uric acid (UA), a natural neuroprotectant, have also a better disease course. Our aim was to investigate whether PD motor subtypes...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5373593?pdf=render |
| _version_ | 1818325042066358272 |
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| author | Ismael Huertas Silvia Jesús José Antonio Lojo Francisco Javier García-Gómez María Teresa Cáceres-Redondo Juan Manuel Oropesa-Ruiz Fátima Carrillo Laura Vargas-Gonzalez Juan Francisco Martín Rodríguez Pilar Gómez-Garre David García-Solís Pablo Mir |
| author_facet | Ismael Huertas Silvia Jesús José Antonio Lojo Francisco Javier García-Gómez María Teresa Cáceres-Redondo Juan Manuel Oropesa-Ruiz Fátima Carrillo Laura Vargas-Gonzalez Juan Francisco Martín Rodríguez Pilar Gómez-Garre David García-Solís Pablo Mir |
| author_sort | Ismael Huertas |
| collection | DOAJ |
| description | Parkinson's disease (PD) patients who present with tremor and maintain a predominance of tremor have a better prognosis. Similarly, PD patients with high levels of uric acid (UA), a natural neuroprotectant, have also a better disease course. Our aim was to investigate whether PD motor subtypes differ in their levels of UA, and if these differences correlate with the degree of dopamine transporter (DAT) availability. We included 75 PD patients from whom we collected information about their motor symptoms, DAT imaging and UA concentration levels. Based on the predominance of their motor symptoms, patients were classified into postural instability and gait disorder (PIGD, n = 36), intermediate (I, n = 22), and tremor-dominant (TD, n = 17) subtypes. The levels of UA and striatal DAT were compared across subtypes and the correlation between these two measures was also explored. We found that PIGD patients had lower levels of UA (3.7 vs 4.5 vs 5.3 mg/dL; P<0.001) and striatal DAT than patients with an intermediate or TD phenotype. Furthermore, UA levels significantly correlated with the levels of striatal DAT. We also observed that some PIGD (25%) and I (45%) patients had a predominance of tremor at disease onset. We speculate that UA might be involved in the maintenance of the less damaging TD phenotype and thus also in the conversion from TD to PIGD. Low levels of this natural antioxidant could lead to a major neuronal damage and therefore influence the conversion to a more severe motor phenotype. |
| first_indexed | 2024-12-13T11:38:11Z |
| format | Article |
| id | doaj.art-61d73dd05dd44f138ac5cd6393e23ddb |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T11:38:11Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-61d73dd05dd44f138ac5cd6393e23ddb2022-12-21T23:47:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01123e017464410.1371/journal.pone.0174644Lower levels of uric acid and striatal dopamine in non-tremor dominant Parkinson's disease subtype.Ismael HuertasSilvia JesúsJosé Antonio LojoFrancisco Javier García-GómezMaría Teresa Cáceres-RedondoJuan Manuel Oropesa-RuizFátima CarrilloLaura Vargas-GonzalezJuan Francisco Martín RodríguezPilar Gómez-GarreDavid García-SolísPablo MirParkinson's disease (PD) patients who present with tremor and maintain a predominance of tremor have a better prognosis. Similarly, PD patients with high levels of uric acid (UA), a natural neuroprotectant, have also a better disease course. Our aim was to investigate whether PD motor subtypes differ in their levels of UA, and if these differences correlate with the degree of dopamine transporter (DAT) availability. We included 75 PD patients from whom we collected information about their motor symptoms, DAT imaging and UA concentration levels. Based on the predominance of their motor symptoms, patients were classified into postural instability and gait disorder (PIGD, n = 36), intermediate (I, n = 22), and tremor-dominant (TD, n = 17) subtypes. The levels of UA and striatal DAT were compared across subtypes and the correlation between these two measures was also explored. We found that PIGD patients had lower levels of UA (3.7 vs 4.5 vs 5.3 mg/dL; P<0.001) and striatal DAT than patients with an intermediate or TD phenotype. Furthermore, UA levels significantly correlated with the levels of striatal DAT. We also observed that some PIGD (25%) and I (45%) patients had a predominance of tremor at disease onset. We speculate that UA might be involved in the maintenance of the less damaging TD phenotype and thus also in the conversion from TD to PIGD. Low levels of this natural antioxidant could lead to a major neuronal damage and therefore influence the conversion to a more severe motor phenotype.http://europepmc.org/articles/PMC5373593?pdf=render |
| spellingShingle | Ismael Huertas Silvia Jesús José Antonio Lojo Francisco Javier García-Gómez María Teresa Cáceres-Redondo Juan Manuel Oropesa-Ruiz Fátima Carrillo Laura Vargas-Gonzalez Juan Francisco Martín Rodríguez Pilar Gómez-Garre David García-Solís Pablo Mir Lower levels of uric acid and striatal dopamine in non-tremor dominant Parkinson's disease subtype. PLoS ONE |
| title | Lower levels of uric acid and striatal dopamine in non-tremor dominant Parkinson's disease subtype. |
| title_full | Lower levels of uric acid and striatal dopamine in non-tremor dominant Parkinson's disease subtype. |
| title_fullStr | Lower levels of uric acid and striatal dopamine in non-tremor dominant Parkinson's disease subtype. |
| title_full_unstemmed | Lower levels of uric acid and striatal dopamine in non-tremor dominant Parkinson's disease subtype. |
| title_short | Lower levels of uric acid and striatal dopamine in non-tremor dominant Parkinson's disease subtype. |
| title_sort | lower levels of uric acid and striatal dopamine in non tremor dominant parkinson s disease subtype |
| url | http://europepmc.org/articles/PMC5373593?pdf=render |
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