Functional Axis of PDE5/cGMP Mediates Timosaponin-AIII-Elicited Growth Suppression of Glioblastoma U87MG Cells

Functional Axis of PDE5/cGMP Mediates Timosaponin-AIII-Elicited Growth Suppression of Glioblastoma U87MG Cells

Glioblastoma (GBM) is the most aggressive brain tumor, with high mortality. Timosaponin AIII (TIA), a steroidal saponin isolated from the medicinal plant <i>Anemarrhena asphodeloides</i> Bge., has been shown to possess anticancer properties in various cancer types. However, the effect of...

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Bibliographic Details
Main Authors: Ya-Fang Liao, Hui-Jun Pan, Nuerziba Abudurezeke, Chun-Lu Yuan, Yan-Li Yuan, Shu-Da Zhao, Dan-Dan Zhang, Shuang Huang
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Molecules
Subjects:
timosaponin AIII
glioblastoma
PDE5
cGMP pathway
β-catenin pathway
Online Access:https://www.mdpi.com/1420-3049/28/9/3795

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