Biological Activities and Solubilization Methodologies of Naringin
Naringin (NG), a natural flavanone glycoside, possesses a multitude of pharmacological properties, encompassing anti-inflammatory, sedative, antioxidant, anticancer, anti-osteoporosis, and lipid-lowering functions, and serves as a facilitator for the absorption of other drugs. Despite these powerful...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/12/12/2327 |
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| author | Hao Jiang Mutang Zhang Xiaoling Lin Xiaoqing Zheng Heming Qi Junping Chen Xiaofang Zeng Weidong Bai Gengsheng Xiao |
| author_facet | Hao Jiang Mutang Zhang Xiaoling Lin Xiaoqing Zheng Heming Qi Junping Chen Xiaofang Zeng Weidong Bai Gengsheng Xiao |
| author_sort | Hao Jiang |
| collection | DOAJ |
| description | Naringin (NG), a natural flavanone glycoside, possesses a multitude of pharmacological properties, encompassing anti-inflammatory, sedative, antioxidant, anticancer, anti-osteoporosis, and lipid-lowering functions, and serves as a facilitator for the absorption of other drugs. Despite these powerful qualities, NG’s limited solubility and bioavailability primarily undermine its therapeutic potential. Consequently, innovative solubilization methodologies have received considerable attention, propelling a surge of scholarly investigation in this arena. Among the most promising solutions is the enhancement of NG’s solubility and physiological activity without compromising its inherent active structure, therefore enabling the formulation of non-toxic and benign human body preparations. This article delivers a comprehensive overview of NG and its physiological activities, particularly emphasizing the impacts of structural modification, solid dispersions (SDs), inclusion compound, polymeric micelle, liposomes, and nanoparticles on NG solubilization. By synthesizing current research, this research elucidates the bioavailability of NG, broadens its clinical applicability, and paves the way for further exploration and expansion of its application spectrum. |
| first_indexed | 2024-03-11T02:28:41Z |
| format | Article |
| id | doaj.art-61db55c7e802420a862fa5b157c09604 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-11T02:28:41Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-61db55c7e802420a862fa5b157c096042023-11-18T10:24:11ZengMDPI AGFoods2304-81582023-06-011212232710.3390/foods12122327Biological Activities and Solubilization Methodologies of NaringinHao Jiang0Mutang Zhang1Xiaoling Lin2Xiaoqing Zheng3Heming Qi4Junping Chen5Xiaofang Zeng6Weidong Bai7Gengsheng Xiao8Guangdong Provincial Key Laboratory of Lingnan Specialty Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, ChinaCollege of Light Industry and Food Sciences, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, ChinaCollege of Light Industry and Food Sciences, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, ChinaCollege of Light Industry and Food Sciences, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, ChinaScience and Technology Research Center of China Customs, Beijing 100026, ChinaMeizhou Feilong Fruit Co., Ltd., Meizhou 514600, ChinaGuangdong Provincial Key Laboratory of Lingnan Specialty Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, ChinaGuangdong Provincial Key Laboratory of Lingnan Specialty Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, ChinaGuangdong Provincial Key Laboratory of Lingnan Specialty Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, ChinaNaringin (NG), a natural flavanone glycoside, possesses a multitude of pharmacological properties, encompassing anti-inflammatory, sedative, antioxidant, anticancer, anti-osteoporosis, and lipid-lowering functions, and serves as a facilitator for the absorption of other drugs. Despite these powerful qualities, NG’s limited solubility and bioavailability primarily undermine its therapeutic potential. Consequently, innovative solubilization methodologies have received considerable attention, propelling a surge of scholarly investigation in this arena. Among the most promising solutions is the enhancement of NG’s solubility and physiological activity without compromising its inherent active structure, therefore enabling the formulation of non-toxic and benign human body preparations. This article delivers a comprehensive overview of NG and its physiological activities, particularly emphasizing the impacts of structural modification, solid dispersions (SDs), inclusion compound, polymeric micelle, liposomes, and nanoparticles on NG solubilization. By synthesizing current research, this research elucidates the bioavailability of NG, broadens its clinical applicability, and paves the way for further exploration and expansion of its application spectrum.https://www.mdpi.com/2304-8158/12/12/2327naringinphysiological activitysolubilizationsolubilitybioavailability |
| spellingShingle | Hao Jiang Mutang Zhang Xiaoling Lin Xiaoqing Zheng Heming Qi Junping Chen Xiaofang Zeng Weidong Bai Gengsheng Xiao Biological Activities and Solubilization Methodologies of Naringin Foods naringin physiological activity solubilization solubility bioavailability |
| title | Biological Activities and Solubilization Methodologies of Naringin |
| title_full | Biological Activities and Solubilization Methodologies of Naringin |
| title_fullStr | Biological Activities and Solubilization Methodologies of Naringin |
| title_full_unstemmed | Biological Activities and Solubilization Methodologies of Naringin |
| title_short | Biological Activities and Solubilization Methodologies of Naringin |
| title_sort | biological activities and solubilization methodologies of naringin |
| topic | naringin physiological activity solubilization solubility bioavailability |
| url | https://www.mdpi.com/2304-8158/12/12/2327 |
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