<i>Lactobacillus plantarum</i> TWK10 Improves Muscle Mass and Functional Performance in Frail Older Adults: A Randomized, Double-Blind Clinical Trial
Sarcopenia is a condition in which there is a loss of muscle caused by aging and it is one of the most significant factors that affects physical fragility. In recent years, the role of the gut–muscle axis has garnered attention as, along with the gut microbiota, it potentially plays a significant ro...
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MDPI AG
2021-07-01
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| Online Access: | https://www.mdpi.com/2076-2607/9/7/1466 |
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| author | Mon-Chien Lee Yu-Tsai Tu Chia-Chia Lee Shiow-Chwen Tsai Han-Yin Hsu Tsung-Yu Tsai Te-Hua Liu San-Land Young Jin-Seng Lin Chi-Chang Huang |
| author_facet | Mon-Chien Lee Yu-Tsai Tu Chia-Chia Lee Shiow-Chwen Tsai Han-Yin Hsu Tsung-Yu Tsai Te-Hua Liu San-Land Young Jin-Seng Lin Chi-Chang Huang |
| author_sort | Mon-Chien Lee |
| collection | DOAJ |
| description | Sarcopenia is a condition in which there is a loss of muscle caused by aging and it is one of the most significant factors that affects physical fragility. In recent years, the role of the gut–muscle axis has garnered attention as, along with the gut microbiota, it potentially plays a significant role in muscle regeneration, in addition to nutritional supplements and exercise training. Past studies have found that supplementation with <i>Lactobacillus plantarum</i> TWK10 could effectively increase the muscle mass of animals or adult humans. Therefore, in this study, we investigated whether the supplementation of <i>L. plantarum</i> TWK10 produces increased muscle mass and improves the functional performance of elderly persons with mild fragility. A total of 68 elderly subjects were recruited, of which 13 subjects were excluded or withdrew from the study. We adopted a double-blind design, and the 55 subjects were randomly divided into three groups: the placebo group, the TWK10 low-dose group (2 × 10<sup>10</sup> CFU/day) (TWK10-L), and the TWK10 high-dose group (6 × 10<sup>10</sup> colony-forming unit (CFU)/day) (TWK10-H). For 18 weeks, all subjects were required to regularly take experimental samples, perform functional activity testing, and have their body composition analyzed before the study and every six weeks after the intervention. Finally, 17 subjects in the placebo group, 12 subjects in the TWK10-L group, and 13 subjects in the TWK10-H group finished the study. It was found that supplementation with TWK10 had a tendency to increase and improve muscle mass, left hand grip strength, lower limb muscle strength, and gait speed and balance after the sixth week, especially in the TWK10-H group, and, as the supplement time was longer up to the 18th week, it had an even greater effect (<i>p</i> < 0.05). In conclusion, consecutive supplementation of <i>L. plantarum</i> TWK10 for more than six weeks could effectively improve the muscle strength and endurance of the elderly, reducing sarcopenia and physical fragility. This trial was registered as NCT04893746. |
| first_indexed | 2024-03-10T09:31:27Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T09:31:27Z |
| publishDate | 2021-07-01 |
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| spelling | doaj.art-61dbc90ed5094a55a016f7bea70c4d3f2023-11-22T04:26:10ZengMDPI AGMicroorganisms2076-26072021-07-0197146610.3390/microorganisms9071466<i>Lactobacillus plantarum</i> TWK10 Improves Muscle Mass and Functional Performance in Frail Older Adults: A Randomized, Double-Blind Clinical TrialMon-Chien Lee0Yu-Tsai Tu1Chia-Chia Lee2Shiow-Chwen Tsai3Han-Yin Hsu4Tsung-Yu Tsai5Te-Hua Liu6San-Land Young7Jin-Seng Lin8Chi-Chang Huang9Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan City 333325, TaiwanGraduate Institute of Sports Science, National Taiwan Sport University, Taoyuan City 333325, TaiwanCulture Collection & Research Institute, SYNBIO TECH INC., Kaohsiung City 82151, TaiwanInstitute of Sports Sciences, University of Taipei, Taipei City 112, TaiwanCulture Collection & Research Institute, SYNBIO TECH INC., Kaohsiung City 82151, TaiwanDepartment of Food Science, Fu Jen Catholic University, New Taipei City 24205, TaiwanDepartment of Food Science, Fu Jen Catholic University, New Taipei City 24205, TaiwanCulture Collection & Research Institute, SYNBIO TECH INC., Kaohsiung City 82151, TaiwanCulture Collection & Research Institute, SYNBIO TECH INC., Kaohsiung City 82151, TaiwanGraduate Institute of Sports Science, National Taiwan Sport University, Taoyuan City 333325, TaiwanSarcopenia is a condition in which there is a loss of muscle caused by aging and it is one of the most significant factors that affects physical fragility. In recent years, the role of the gut–muscle axis has garnered attention as, along with the gut microbiota, it potentially plays a significant role in muscle regeneration, in addition to nutritional supplements and exercise training. Past studies have found that supplementation with <i>Lactobacillus plantarum</i> TWK10 could effectively increase the muscle mass of animals or adult humans. Therefore, in this study, we investigated whether the supplementation of <i>L. plantarum</i> TWK10 produces increased muscle mass and improves the functional performance of elderly persons with mild fragility. A total of 68 elderly subjects were recruited, of which 13 subjects were excluded or withdrew from the study. We adopted a double-blind design, and the 55 subjects were randomly divided into three groups: the placebo group, the TWK10 low-dose group (2 × 10<sup>10</sup> CFU/day) (TWK10-L), and the TWK10 high-dose group (6 × 10<sup>10</sup> colony-forming unit (CFU)/day) (TWK10-H). For 18 weeks, all subjects were required to regularly take experimental samples, perform functional activity testing, and have their body composition analyzed before the study and every six weeks after the intervention. Finally, 17 subjects in the placebo group, 12 subjects in the TWK10-L group, and 13 subjects in the TWK10-H group finished the study. It was found that supplementation with TWK10 had a tendency to increase and improve muscle mass, left hand grip strength, lower limb muscle strength, and gait speed and balance after the sixth week, especially in the TWK10-H group, and, as the supplement time was longer up to the 18th week, it had an even greater effect (<i>p</i> < 0.05). In conclusion, consecutive supplementation of <i>L. plantarum</i> TWK10 for more than six weeks could effectively improve the muscle strength and endurance of the elderly, reducing sarcopenia and physical fragility. This trial was registered as NCT04893746.https://www.mdpi.com/2076-2607/9/7/1466<i>Lactobacillus plantarum</i>elderlyagingmuscle masssarcopeniaphysical fragility |
| spellingShingle | Mon-Chien Lee Yu-Tsai Tu Chia-Chia Lee Shiow-Chwen Tsai Han-Yin Hsu Tsung-Yu Tsai Te-Hua Liu San-Land Young Jin-Seng Lin Chi-Chang Huang <i>Lactobacillus plantarum</i> TWK10 Improves Muscle Mass and Functional Performance in Frail Older Adults: A Randomized, Double-Blind Clinical Trial Microorganisms <i>Lactobacillus plantarum</i> elderly aging muscle mass sarcopenia physical fragility |
| title | <i>Lactobacillus plantarum</i> TWK10 Improves Muscle Mass and Functional Performance in Frail Older Adults: A Randomized, Double-Blind Clinical Trial |
| title_full | <i>Lactobacillus plantarum</i> TWK10 Improves Muscle Mass and Functional Performance in Frail Older Adults: A Randomized, Double-Blind Clinical Trial |
| title_fullStr | <i>Lactobacillus plantarum</i> TWK10 Improves Muscle Mass and Functional Performance in Frail Older Adults: A Randomized, Double-Blind Clinical Trial |
| title_full_unstemmed | <i>Lactobacillus plantarum</i> TWK10 Improves Muscle Mass and Functional Performance in Frail Older Adults: A Randomized, Double-Blind Clinical Trial |
| title_short | <i>Lactobacillus plantarum</i> TWK10 Improves Muscle Mass and Functional Performance in Frail Older Adults: A Randomized, Double-Blind Clinical Trial |
| title_sort | i lactobacillus plantarum i twk10 improves muscle mass and functional performance in frail older adults a randomized double blind clinical trial |
| topic | <i>Lactobacillus plantarum</i> elderly aging muscle mass sarcopenia physical fragility |
| url | https://www.mdpi.com/2076-2607/9/7/1466 |
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