Relative contributions of arterial stiffness to cardiovascular disease risk score in Chinese women in framingham and China-PAR model
BackgroundArterial stiffness played an important role in the development of cardiovascular disease (CVD) events. The aim of this study was to verify the relative importance of arterial stiffness for different CVD risk scores in a large sample of Chinese women.MethodsWe measured arterial velocity pul...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-06-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1169250/full |
| _version_ | 1797803793684889600 |
|---|---|
| author | Lin Jin Lin Jin Jianxiong Chen Lingheng Wu Mengjiao Zhang Jiali Sun Cuiqin Shen Lianfang Du Dingqian Wang Zhaojun Li Zhaojun Li |
| author_facet | Lin Jin Lin Jin Jianxiong Chen Lingheng Wu Mengjiao Zhang Jiali Sun Cuiqin Shen Lianfang Du Dingqian Wang Zhaojun Li Zhaojun Li |
| author_sort | Lin Jin |
| collection | DOAJ |
| description | BackgroundArterial stiffness played an important role in the development of cardiovascular disease (CVD) events. The aim of this study was to verify the relative importance of arterial stiffness for different CVD risk scores in a large sample of Chinese women.MethodsWe measured arterial velocity pulse index (AVI) and CVD risk scores in 2220 female participants (mean age 57 years). Framingham Risk Score (FRS), and the prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) were used to estimate CVD risk, respectively. The relationships between AVI and risk scores were investigated by linear regressions and restricted cubic spline (RCS) analysis. To determine the relative importance of AVI in predicting CVD risk scores, random forest analysis was used.ResultsThere was a significant positive correlation between AVI and FRS, China-PAR in all subgroup groups stratified by age, blood pressure and BMI. AVI showed higher importance in predicting CVD risk scores in FRS model, compared with these traditional risk factors. In China-PAR model, although AVI was not as predictive as SBP, it had better predictive power than many known risk factors such as lipids. Furthermore, AVI had significant J-shaped associations both with FRS and China-PAR scores.ConclusionsAVI was significantly associated with CVD risk score. In FRS and China-PAR model, AVI showed relatively high importance in predicting CVD risk scores. These findings may support the use of arterial stiffness measurements in CVD risk assessment. |
| first_indexed | 2024-03-13T05:27:21Z |
| format | Article |
| id | doaj.art-61de79b9636b4a799b21ddbb8617c24e |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-13T05:27:21Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-61de79b9636b4a799b21ddbb8617c24e2023-06-15T05:13:54ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-06-011010.3389/fcvm.2023.11692501169250Relative contributions of arterial stiffness to cardiovascular disease risk score in Chinese women in framingham and China-PAR modelLin Jin0Lin Jin1Jianxiong Chen2Lingheng Wu3Mengjiao Zhang4Jiali Sun5Cuiqin Shen6Lianfang Du7Dingqian Wang8Zhaojun Li9Zhaojun Li10Department of Ultrasound, Jiading Branch of Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Ultrasound, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Ultrasound, Mindong Hospital Affiliated to Fujian Medical University, Ningde, ChinaDepartment of Ultrasound, Mindong Hospital Affiliated to Fujian Medical University, Ningde, ChinaDepartment of Ultrasound, Jiading Branch of Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Ultrasound, Jiading Branch of Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Ultrasound, Jiading Branch of Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Ultrasound, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaSchool of Informatics, College of Science & Engineering, The University of Edinburgh, Edinburgh, United KingdomDepartment of Ultrasound, Jiading Branch of Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Ultrasound, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaBackgroundArterial stiffness played an important role in the development of cardiovascular disease (CVD) events. The aim of this study was to verify the relative importance of arterial stiffness for different CVD risk scores in a large sample of Chinese women.MethodsWe measured arterial velocity pulse index (AVI) and CVD risk scores in 2220 female participants (mean age 57 years). Framingham Risk Score (FRS), and the prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) were used to estimate CVD risk, respectively. The relationships between AVI and risk scores were investigated by linear regressions and restricted cubic spline (RCS) analysis. To determine the relative importance of AVI in predicting CVD risk scores, random forest analysis was used.ResultsThere was a significant positive correlation between AVI and FRS, China-PAR in all subgroup groups stratified by age, blood pressure and BMI. AVI showed higher importance in predicting CVD risk scores in FRS model, compared with these traditional risk factors. In China-PAR model, although AVI was not as predictive as SBP, it had better predictive power than many known risk factors such as lipids. Furthermore, AVI had significant J-shaped associations both with FRS and China-PAR scores.ConclusionsAVI was significantly associated with CVD risk score. In FRS and China-PAR model, AVI showed relatively high importance in predicting CVD risk scores. These findings may support the use of arterial stiffness measurements in CVD risk assessment.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1169250/fullarterial stiffnesscardiovascular diseaserisk factorsfemalerisk score |
| spellingShingle | Lin Jin Lin Jin Jianxiong Chen Lingheng Wu Mengjiao Zhang Jiali Sun Cuiqin Shen Lianfang Du Dingqian Wang Zhaojun Li Zhaojun Li Relative contributions of arterial stiffness to cardiovascular disease risk score in Chinese women in framingham and China-PAR model Frontiers in Cardiovascular Medicine arterial stiffness cardiovascular disease risk factors female risk score |
| title | Relative contributions of arterial stiffness to cardiovascular disease risk score in Chinese women in framingham and China-PAR model |
| title_full | Relative contributions of arterial stiffness to cardiovascular disease risk score in Chinese women in framingham and China-PAR model |
| title_fullStr | Relative contributions of arterial stiffness to cardiovascular disease risk score in Chinese women in framingham and China-PAR model |
| title_full_unstemmed | Relative contributions of arterial stiffness to cardiovascular disease risk score in Chinese women in framingham and China-PAR model |
| title_short | Relative contributions of arterial stiffness to cardiovascular disease risk score in Chinese women in framingham and China-PAR model |
| title_sort | relative contributions of arterial stiffness to cardiovascular disease risk score in chinese women in framingham and china par model |
| topic | arterial stiffness cardiovascular disease risk factors female risk score |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1169250/full |
| work_keys_str_mv | AT linjin relativecontributionsofarterialstiffnesstocardiovasculardiseaseriskscoreinchinesewomeninframinghamandchinaparmodel AT linjin relativecontributionsofarterialstiffnesstocardiovasculardiseaseriskscoreinchinesewomeninframinghamandchinaparmodel AT jianxiongchen relativecontributionsofarterialstiffnesstocardiovasculardiseaseriskscoreinchinesewomeninframinghamandchinaparmodel AT linghengwu relativecontributionsofarterialstiffnesstocardiovasculardiseaseriskscoreinchinesewomeninframinghamandchinaparmodel AT mengjiaozhang relativecontributionsofarterialstiffnesstocardiovasculardiseaseriskscoreinchinesewomeninframinghamandchinaparmodel AT jialisun relativecontributionsofarterialstiffnesstocardiovasculardiseaseriskscoreinchinesewomeninframinghamandchinaparmodel AT cuiqinshen relativecontributionsofarterialstiffnesstocardiovasculardiseaseriskscoreinchinesewomeninframinghamandchinaparmodel AT lianfangdu relativecontributionsofarterialstiffnesstocardiovasculardiseaseriskscoreinchinesewomeninframinghamandchinaparmodel AT dingqianwang relativecontributionsofarterialstiffnesstocardiovasculardiseaseriskscoreinchinesewomeninframinghamandchinaparmodel AT zhaojunli relativecontributionsofarterialstiffnesstocardiovasculardiseaseriskscoreinchinesewomeninframinghamandchinaparmodel AT zhaojunli relativecontributionsofarterialstiffnesstocardiovasculardiseaseriskscoreinchinesewomeninframinghamandchinaparmodel |