Unraveling Histone Loss in Aging and Senescence
As the global population experiences a notable surge in aging demographics, the need to understand the intricate molecular pathways exacerbated by age-related stresses, including epigenetic dysregulation, becomes a priority. Epigenetic mechanisms play a critical role in driving age-related diseases...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-02-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/13/4/320 |
| _version_ | 1797298617212469248 |
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| author | Sushil Kumar Dubey Rashmi Dubey Mark Ellsworth Kleinman |
| author_facet | Sushil Kumar Dubey Rashmi Dubey Mark Ellsworth Kleinman |
| author_sort | Sushil Kumar Dubey |
| collection | DOAJ |
| description | As the global population experiences a notable surge in aging demographics, the need to understand the intricate molecular pathways exacerbated by age-related stresses, including epigenetic dysregulation, becomes a priority. Epigenetic mechanisms play a critical role in driving age-related diseases through altered gene expression, genomic instability, and irregular chromatin remodeling. In this review, we focus on histones, a central component of the epigenome, and consolidate the key findings of histone loss and genome-wide redistribution as fundamental processes contributing to aging and senescence. The review provides insights into novel histone expression profiles, nucleosome occupancy, disruptions in higher-order chromatin architecture, and the emergence of noncanonical histone variants in the aging cellular landscape. Furthermore, we explore the current state of our understanding of the molecular mechanisms of histone deficiency in aging cells. Specific emphasis is placed on highlighting histone degradation pathways in the cell and studies that have explored potential strategies to mitigate histone loss or restore histone levels in aging cells. Finally, in addressing future perspectives, the insights gained from this review hold profound implications for advancing strategies that actively intervene in modulating histone expression profiles in the context of cellular aging and identifying potential therapeutic targets for alleviating a multitude of age-related diseases. |
| first_indexed | 2024-03-07T22:37:38Z |
| format | Article |
| id | doaj.art-61e004d43fc44a48a38d687f393eb429 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-07T22:37:38Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-61e004d43fc44a48a38d687f393eb4292024-02-23T15:11:43ZengMDPI AGCells2073-44092024-02-0113432010.3390/cells13040320Unraveling Histone Loss in Aging and SenescenceSushil Kumar Dubey0Rashmi Dubey1Mark Ellsworth Kleinman2Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USADepartment of Surgery, East Tennessee State University, Johnson City, TN 37614, USADepartment of Surgery, East Tennessee State University, Johnson City, TN 37614, USAAs the global population experiences a notable surge in aging demographics, the need to understand the intricate molecular pathways exacerbated by age-related stresses, including epigenetic dysregulation, becomes a priority. Epigenetic mechanisms play a critical role in driving age-related diseases through altered gene expression, genomic instability, and irregular chromatin remodeling. In this review, we focus on histones, a central component of the epigenome, and consolidate the key findings of histone loss and genome-wide redistribution as fundamental processes contributing to aging and senescence. The review provides insights into novel histone expression profiles, nucleosome occupancy, disruptions in higher-order chromatin architecture, and the emergence of noncanonical histone variants in the aging cellular landscape. Furthermore, we explore the current state of our understanding of the molecular mechanisms of histone deficiency in aging cells. Specific emphasis is placed on highlighting histone degradation pathways in the cell and studies that have explored potential strategies to mitigate histone loss or restore histone levels in aging cells. Finally, in addressing future perspectives, the insights gained from this review hold profound implications for advancing strategies that actively intervene in modulating histone expression profiles in the context of cellular aging and identifying potential therapeutic targets for alleviating a multitude of age-related diseases.https://www.mdpi.com/2073-4409/13/4/320histonesnucleosome occupancyagingsenescenceepigeneticshistone degradation |
| spellingShingle | Sushil Kumar Dubey Rashmi Dubey Mark Ellsworth Kleinman Unraveling Histone Loss in Aging and Senescence Cells histones nucleosome occupancy aging senescence epigenetics histone degradation |
| title | Unraveling Histone Loss in Aging and Senescence |
| title_full | Unraveling Histone Loss in Aging and Senescence |
| title_fullStr | Unraveling Histone Loss in Aging and Senescence |
| title_full_unstemmed | Unraveling Histone Loss in Aging and Senescence |
| title_short | Unraveling Histone Loss in Aging and Senescence |
| title_sort | unraveling histone loss in aging and senescence |
| topic | histones nucleosome occupancy aging senescence epigenetics histone degradation |
| url | https://www.mdpi.com/2073-4409/13/4/320 |
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