Altered expression of K13 disrupts DNA replication and repair in Plasmodium falciparum

Altered expression of K13 disrupts DNA replication and repair in Plasmodium falciparum

Abstract Background Plasmodium falciparum exhibits resistance to the artemisinin component of the frontline antimalarial treatment Artemisinin-based Combination Therapy in South East Asia. Millions of lives will be at risk if artemisinin resistance (ART-R) spreads to Africa. Single non-synonymous mu...

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Bibliographic Details
Main Authors: Justin Gibbons, Katrina A. Button-Simons, Swamy R. Adapa, Suzanne Li, Maxwell Pietsch, Min Zhang, Xiangyun Liao, John H. Adams, Michael T. Ferdig, Rays H. Y. Jiang
Format: Article
Language:English
Published: BMC 2018-11-01
Series:BMC Genomics
Subjects:
Malaria
Artemisinin
K13
Drug-resistance
Online Access:http://link.springer.com/article/10.1186/s12864-018-5207-7

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