No effect of the angiotensin receptor blocker candesartan on cerebrovascular autoregulation in rats during very high and low sodium intake
Autoregulation of cerebral blood flow (CBF) denotes that CBF is constant despite fluctuation of blood pressure within wide limits. Inhibition of the renin–angiotensin system (RAS) is known to decrease the lower and upper limits of CBF autoregulation. We have previously shown that this includes inhib...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publications
2019-09-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320319874615 |
| _version_ | 1797288561999872000 |
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| author | Sigurdur T Sigurdsson Peter Bie Arne H Nielsen Svend Strandgaard Olaf B Paulson |
| author_facet | Sigurdur T Sigurdsson Peter Bie Arne H Nielsen Svend Strandgaard Olaf B Paulson |
| author_sort | Sigurdur T Sigurdsson |
| collection | DOAJ |
| description | Autoregulation of cerebral blood flow (CBF) denotes that CBF is constant despite fluctuation of blood pressure within wide limits. Inhibition of the renin–angiotensin system (RAS) is known to decrease the lower and upper limits of CBF autoregulation. We have previously shown that this includes inhibition by the angiotensin receptor blocker (ARB) candesartan. In the present study we investigated the influence of the ARB candesartan on the lower limit of CBF autoregulation in two groups of Sprague-Dawley rats, on high (4.0% Na + ) and low (0.004% Na + ) sodium diet, respectively. Control animals were given the same diet, but no ARB. CBF was studied with the laser Doppler method. Blood pressure was lowered by controlled bleeding. Results revealed that both high and low sodium diet with low and high renin levels respectively block the influence of candesartan on CBF autoregulation. This was expected in rats on a high salt diet with a low renin level, but unexpected in rats with a low salt intake with a high renin level. |
| first_indexed | 2024-03-07T18:51:18Z |
| format | Article |
| id | doaj.art-61e09d99d7f44102bf69778fb075fb76 |
| institution | Directory Open Access Journal |
| issn | 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T18:51:18Z |
| publishDate | 2019-09-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-61e09d99d7f44102bf69778fb075fb762024-03-02T01:21:46ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1752-89762019-09-012010.1177/1470320319874615No effect of the angiotensin receptor blocker candesartan on cerebrovascular autoregulation in rats during very high and low sodium intakeSigurdur T Sigurdsson0Peter Bie1Arne H Nielsen2Svend Strandgaard3Olaf B Paulson4Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, DenmarkDepartment of Molecular Medicine, University of Southern Denmark, Odense, DenmarkDepartment of Nephrology, Copenhagen University Hospital at Herlev, DenmarkDepartment of Nephrology, Copenhagen University Hospital at Herlev, DenmarkDepartment of Clinical Medicine, University of Copenhagen, DenmarkAutoregulation of cerebral blood flow (CBF) denotes that CBF is constant despite fluctuation of blood pressure within wide limits. Inhibition of the renin–angiotensin system (RAS) is known to decrease the lower and upper limits of CBF autoregulation. We have previously shown that this includes inhibition by the angiotensin receptor blocker (ARB) candesartan. In the present study we investigated the influence of the ARB candesartan on the lower limit of CBF autoregulation in two groups of Sprague-Dawley rats, on high (4.0% Na + ) and low (0.004% Na + ) sodium diet, respectively. Control animals were given the same diet, but no ARB. CBF was studied with the laser Doppler method. Blood pressure was lowered by controlled bleeding. Results revealed that both high and low sodium diet with low and high renin levels respectively block the influence of candesartan on CBF autoregulation. This was expected in rats on a high salt diet with a low renin level, but unexpected in rats with a low salt intake with a high renin level.https://doi.org/10.1177/1470320319874615 |
| spellingShingle | Sigurdur T Sigurdsson Peter Bie Arne H Nielsen Svend Strandgaard Olaf B Paulson No effect of the angiotensin receptor blocker candesartan on cerebrovascular autoregulation in rats during very high and low sodium intake Journal of the Renin-Angiotensin-Aldosterone System |
| title | No effect of the angiotensin receptor blocker candesartan on cerebrovascular autoregulation in rats during very high and low sodium intake |
| title_full | No effect of the angiotensin receptor blocker candesartan on cerebrovascular autoregulation in rats during very high and low sodium intake |
| title_fullStr | No effect of the angiotensin receptor blocker candesartan on cerebrovascular autoregulation in rats during very high and low sodium intake |
| title_full_unstemmed | No effect of the angiotensin receptor blocker candesartan on cerebrovascular autoregulation in rats during very high and low sodium intake |
| title_short | No effect of the angiotensin receptor blocker candesartan on cerebrovascular autoregulation in rats during very high and low sodium intake |
| title_sort | no effect of the angiotensin receptor blocker candesartan on cerebrovascular autoregulation in rats during very high and low sodium intake |
| url | https://doi.org/10.1177/1470320319874615 |
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