Genome-wide chromosomal instability by cell-free DNA sequencing predicts survival in patients with metastatic breast cancer

Genome-wide chromosomal instability by cell-free DNA sequencing predicts survival in patients with metastatic breast cancer

Background: Genome-wide chromosomal instability, instead of specific somatic mutations or copy-number alterations in selected genes, is a significant property of cancer and may suggest a new strategy for treatment. Here we utilized cell-free DNA (cfDNA) sequencing to display the whole picture of chr...

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Bibliographic Details
Main Authors: Hongnan Mo, Xiaobing Wang, Fei Ma, Ziliang Qian, Xiaoying Sun, Zongbi Yi, Xiuwen Guan, Lixi Li, Binliang Liu, Binghe Xu
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Breast
Subjects:
Cell-free nucleic acids
Chromosomal instability
DNA Copy number alteration
Breast neoplasms
Prognosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0960977620301466

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