Afamin and adropin in patients with alcohol-induced liver cirrhosis
The aim of the study was to determine serum concentrations of afamin and adropin in patients with alcoholic liver cirrhosis and to define their correlation with the stage of disease. The study included 99 patients with alcoholic cirrhosis from the region of Lublin, (Eastern Poland). Liver cirrhosis...
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Institute of Rural Health
2018-09-01
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| Series: | Annals of Agricultural and Environmental Medicine |
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| Online Access: | http://www.journalssystem.com/aaem/Afamin-and-adropin-in-patients-with-alcohol-induced-liver-cirrhosis,92650,0,2.html |
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| author | Andrzej Prystupa Paweł Kiciński Dorota Luchowska-Kocot Jarosław Sak Tomasz Prystupa Ko-Hsin Chen Yu-Chieh Chen Lech Panasiuk Wojciech Załuska |
| author_facet | Andrzej Prystupa Paweł Kiciński Dorota Luchowska-Kocot Jarosław Sak Tomasz Prystupa Ko-Hsin Chen Yu-Chieh Chen Lech Panasiuk Wojciech Załuska |
| author_sort | Andrzej Prystupa |
| collection | DOAJ |
| description | The aim of the study was to determine serum concentrations of afamin and adropin in patients with alcoholic liver cirrhosis and to define their correlation with the stage of disease. The study included 99 patients with alcoholic cirrhosis from the region of Lublin, (Eastern Poland). Liver cirrhosis was diagnosed based on clinical features, history of heavy alcohol consumption, laboratory tests and abdominal ultrasonography. The control group consisted of 20 healthy individuals without liver disease who did not abuse alcohol. The serum afamin and adropin concentrations were determined using ELISA kits. The concentration of afamin was found to be significantly lower in patients with compensated alcoholic liver cirrhosis, i.e. P-Ch B (85.1±40.6 μg/ml) and P-Ch C (56.4±32.3 μg/ml) individuals, compared to the control group (135.9±43.6 μg/ml); p-value was <0.01 and <0.001, respectively. As far as adropin is concerned, a reverse relationship was demonstrated: the highest concentration was found in patients with P-Ch C (11.7±5.7 ng/ml) cirrhosis. Furthermore, the above concentration was significantly higher compared to patients with P-Ch A cirrhosis (7.2±2.8 ng/ml; p<0.05) and controls (7.5±2.6 ng/ml; p<0.05). The concentration of afamin decreases with the severity of alcoholic liver cirrhosis, which most likely results from impaired hepatic synthesis. Otherwise, the higher the stage of disease according to the Child-Pugh score, the higher the concentration of adropin. |
| first_indexed | 2024-12-21T19:33:17Z |
| format | Article |
| id | doaj.art-61e59ff27f284967a193ff01ae9ee8a9 |
| institution | Directory Open Access Journal |
| issn | 1232-1966 1898-2263 |
| language | English |
| last_indexed | 2024-12-21T19:33:17Z |
| publishDate | 2018-09-01 |
| publisher | Institute of Rural Health |
| record_format | Article |
| series | Annals of Agricultural and Environmental Medicine |
| spelling | doaj.art-61e59ff27f284967a193ff01ae9ee8a92022-12-21T18:52:39ZengInstitute of Rural HealthAnnals of Agricultural and Environmental Medicine1232-19661898-22632018-09-0125352753110.26444/aaem/9265092650Afamin and adropin in patients with alcohol-induced liver cirrhosisAndrzej Prystupa0Paweł Kiciński1Dorota Luchowska-Kocot2Jarosław Sak3Tomasz Prystupa4Ko-Hsin Chen5Yu-Chieh Chen6Lech Panasiuk7Wojciech Załuska8Department of Internal Medicine, Medical University of Lublin, Lublin, PolandDepartment of Experimental Hematooncology, Medical University of Lublin, Lublin, PolandDepartment of Medical Chemistry, Medical University of Lublin, Lublin, PolandDepartment of Ethics and Human Philosophy, Medical University of Lublin, Lublin, PolandIndependent Public Teaching Hospital No 4 in Lublin, PolandStudents' Scientific Society, Medical University of Lublin, Lublin, PolandStudents' Scientific Society, Medical University of Lublin, Lublin, PolandDepartment of Internal Diseases and Hypertension, Institute of Rural Medicine, Lublin, PolandDepartment of Nephrology, Medical University of Lublin, Lublin, PolandThe aim of the study was to determine serum concentrations of afamin and adropin in patients with alcoholic liver cirrhosis and to define their correlation with the stage of disease. The study included 99 patients with alcoholic cirrhosis from the region of Lublin, (Eastern Poland). Liver cirrhosis was diagnosed based on clinical features, history of heavy alcohol consumption, laboratory tests and abdominal ultrasonography. The control group consisted of 20 healthy individuals without liver disease who did not abuse alcohol. The serum afamin and adropin concentrations were determined using ELISA kits. The concentration of afamin was found to be significantly lower in patients with compensated alcoholic liver cirrhosis, i.e. P-Ch B (85.1±40.6 μg/ml) and P-Ch C (56.4±32.3 μg/ml) individuals, compared to the control group (135.9±43.6 μg/ml); p-value was <0.01 and <0.001, respectively. As far as adropin is concerned, a reverse relationship was demonstrated: the highest concentration was found in patients with P-Ch C (11.7±5.7 ng/ml) cirrhosis. Furthermore, the above concentration was significantly higher compared to patients with P-Ch A cirrhosis (7.2±2.8 ng/ml; p<0.05) and controls (7.5±2.6 ng/ml; p<0.05). The concentration of afamin decreases with the severity of alcoholic liver cirrhosis, which most likely results from impaired hepatic synthesis. Otherwise, the higher the stage of disease according to the Child-Pugh score, the higher the concentration of adropin.http://www.journalssystem.com/aaem/Afamin-and-adropin-in-patients-with-alcohol-induced-liver-cirrhosis,92650,0,2.htmlalcoholic liver cirrhosisAdropinChild-Pugh scoreafamin |
| spellingShingle | Andrzej Prystupa Paweł Kiciński Dorota Luchowska-Kocot Jarosław Sak Tomasz Prystupa Ko-Hsin Chen Yu-Chieh Chen Lech Panasiuk Wojciech Załuska Afamin and adropin in patients with alcohol-induced liver cirrhosis Annals of Agricultural and Environmental Medicine alcoholic liver cirrhosis Adropin Child-Pugh score afamin |
| title | Afamin and adropin in patients with alcohol-induced liver cirrhosis |
| title_full | Afamin and adropin in patients with alcohol-induced liver cirrhosis |
| title_fullStr | Afamin and adropin in patients with alcohol-induced liver cirrhosis |
| title_full_unstemmed | Afamin and adropin in patients with alcohol-induced liver cirrhosis |
| title_short | Afamin and adropin in patients with alcohol-induced liver cirrhosis |
| title_sort | afamin and adropin in patients with alcohol induced liver cirrhosis |
| topic | alcoholic liver cirrhosis Adropin Child-Pugh score afamin |
| url | http://www.journalssystem.com/aaem/Afamin-and-adropin-in-patients-with-alcohol-induced-liver-cirrhosis,92650,0,2.html |
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