Andrographis Paniculata (Burm. F.) Flavonoid Compound and Prevention of Diabetic Retinopathy
Abstract Purpose: To explore the effect of the flavonoid compounds of Andrographis paniculata by evaluating the glycemic profile, oxidative process, and inflammatory values in rats with diabetic retinopathy (DR). Methods: An extract of A. paniculata was macerated with ethanol which yielded flavonoid...
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| Format: | Article |
| Language: | English |
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Knowledge E
2024-03-01
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| Series: | Journal of Ophthalmic & Vision Research |
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| Online Access: | https://doi.org/10.18502/jovr.v19i1.15435 |
| _version_ | 1797230388534312960 |
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| author | Ramzi Amin Muhammad Apriliandy Shariff Petty Purwanita Mgs Irsan Saleh |
| author_facet | Ramzi Amin Muhammad Apriliandy Shariff Petty Purwanita Mgs Irsan Saleh |
| author_sort | Ramzi Amin |
| collection | DOAJ |
| description | Abstract Purpose: To explore the effect of the flavonoid compounds of Andrographis paniculata by evaluating the glycemic profile, oxidative process, and inflammatory values in rats with diabetic retinopathy (DR). Methods: An extract of A. paniculata was macerated with ethanol which yielded flavonoid compounds. Streptozotocin was utilized to induce diabetes mellitus in male Wistar rats. Vucetic's methods were used to evaluate the retinal vessel diameters. Antioxidant parameters and inflammatory cytokines were assessed in retinal tissue. Results: A funduscopic examination revealed some alterations in the retinal veins. In comparison to the DR group with no treatment, the diameter of the retinal vessels in the DR group that was treated with the flavonoid component of the A. paniculata extract (FAP) at doses of 20 and 40 mg/kg body weight (BW) was significantly smaller (P < 0.05). The DR treatment groups administered with FAP at doses of 20 and 40 mg/kg BW had a greater ability to reduce TNF-alpha and VEGF levels as compared to the DR rats without treatment (P < 0.05), Glutathione, superoxide dismutase (SOD), and catalase levels were increased after receiving FAP at doses of 20 and 40 mg/kg BW (P < 0.05). Conclusion: Administration of doses of 20 and 40 mg/kg BW of the A. paniculata's flavonoid compoundsimproved DR in rats via retinal vessel diameter reduction, TNF- α and VEGF level reduction, and increasing antioxidants, SOD, catalase, and glutathione. |
| first_indexed | 2024-04-24T15:27:42Z |
| format | Article |
| id | doaj.art-61e687ff31254a64a84ebd3423f8449f |
| institution | Directory Open Access Journal |
| issn | 2008-2010 2008-322X |
| language | English |
| last_indexed | 2024-04-24T15:27:42Z |
| publishDate | 2024-03-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj.art-61e687ff31254a64a84ebd3423f8449f2024-04-02T05:30:46ZengKnowledge EJournal of Ophthalmic & Vision Research2008-20102008-322X2024-03-01191334010.18502/jovr.v19i1.15435jovr.v19i1.15435Andrographis Paniculata (Burm. F.) Flavonoid Compound and Prevention of Diabetic RetinopathyRamzi Amin0Muhammad Apriliandy Shariff1Petty Purwanita2Mgs Irsan Saleh3 Department of Ophthalmology, Faculty of Medicine, Universitas Sriwijaya/Dr Moh Hoesin General Hospital, Palembang, Indonesia Department of Ophthalmology, Faculty of Medicine, Universitas Sriwijaya/Dr Moh Hoesin General Hospital, Palembang, Indonesia Department of Ophthalmology, Faculty of Medicine, Universitas Sriwijaya/Dr Moh Hoesin General Hospital, Palembang, Indonesia Department of Pharmacology, Faculty of Medicine, Universitas Sriwijaya, Palembang, IndonesiaAbstract Purpose: To explore the effect of the flavonoid compounds of Andrographis paniculata by evaluating the glycemic profile, oxidative process, and inflammatory values in rats with diabetic retinopathy (DR). Methods: An extract of A. paniculata was macerated with ethanol which yielded flavonoid compounds. Streptozotocin was utilized to induce diabetes mellitus in male Wistar rats. Vucetic's methods were used to evaluate the retinal vessel diameters. Antioxidant parameters and inflammatory cytokines were assessed in retinal tissue. Results: A funduscopic examination revealed some alterations in the retinal veins. In comparison to the DR group with no treatment, the diameter of the retinal vessels in the DR group that was treated with the flavonoid component of the A. paniculata extract (FAP) at doses of 20 and 40 mg/kg body weight (BW) was significantly smaller (P < 0.05). The DR treatment groups administered with FAP at doses of 20 and 40 mg/kg BW had a greater ability to reduce TNF-alpha and VEGF levels as compared to the DR rats without treatment (P < 0.05), Glutathione, superoxide dismutase (SOD), and catalase levels were increased after receiving FAP at doses of 20 and 40 mg/kg BW (P < 0.05). Conclusion: Administration of doses of 20 and 40 mg/kg BW of the A. paniculata's flavonoid compoundsimproved DR in rats via retinal vessel diameter reduction, TNF- α and VEGF level reduction, and increasing antioxidants, SOD, catalase, and glutathione.https://doi.org/10.18502/jovr.v19i1.15435andrographis paniculata antioxidants diabetic retinopathy plant extracts retinal vessels |
| spellingShingle | Ramzi Amin Muhammad Apriliandy Shariff Petty Purwanita Mgs Irsan Saleh Andrographis Paniculata (Burm. F.) Flavonoid Compound and Prevention of Diabetic Retinopathy Journal of Ophthalmic & Vision Research andrographis paniculata antioxidants diabetic retinopathy plant extracts retinal vessels |
| title | Andrographis Paniculata (Burm. F.) Flavonoid Compound
and Prevention of Diabetic Retinopathy |
| title_full | Andrographis Paniculata (Burm. F.) Flavonoid Compound
and Prevention of Diabetic Retinopathy |
| title_fullStr | Andrographis Paniculata (Burm. F.) Flavonoid Compound
and Prevention of Diabetic Retinopathy |
| title_full_unstemmed | Andrographis Paniculata (Burm. F.) Flavonoid Compound
and Prevention of Diabetic Retinopathy |
| title_short | Andrographis Paniculata (Burm. F.) Flavonoid Compound
and Prevention of Diabetic Retinopathy |
| title_sort | andrographis paniculata burm f flavonoid compound and prevention of diabetic retinopathy |
| topic | andrographis paniculata antioxidants diabetic retinopathy plant extracts retinal vessels |
| url | https://doi.org/10.18502/jovr.v19i1.15435 |
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