The Role of the Intestine in the Development of Hyperuricemia
Gout is a common inflammatory arthritis caused by the deposition of sodium urate crystals in the joints. Hyperuricemia is the fundamental factor of gout. The onset of hyperuricemia is related to purine metabolism disorders or uric acid excretion disorders. Current studies have shown that the intesti...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.845684/full |
| _version_ | 1818330923694817280 |
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| author | Hui Yin Hui Yin Na Liu Na Liu Jie Chen Jie Chen |
| author_facet | Hui Yin Hui Yin Na Liu Na Liu Jie Chen Jie Chen |
| author_sort | Hui Yin |
| collection | DOAJ |
| description | Gout is a common inflammatory arthritis caused by the deposition of sodium urate crystals in the joints. Hyperuricemia is the fundamental factor of gout. The onset of hyperuricemia is related to purine metabolism disorders or uric acid excretion disorders. Current studies have shown that the intestine is an important potential organ for the excretion of uric acid outside the kidneys. The excretion of uric acid of gut is mainly achieved through the action of uric acid transporters and the catabolism of intestinal flora, which plays an important role in the body’s uric acid balance. Here we reviewed the effects of intestinal uric acid transporters and intestinal flora on uric acid excretion, and provide new ideas for the treatment of hyperuricemia and gout. |
| first_indexed | 2024-12-13T13:11:40Z |
| format | Article |
| id | doaj.art-61e689d0cc7746ceba8b86b8f3989c0e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T13:11:40Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-61e689d0cc7746ceba8b86b8f3989c0e2022-12-21T23:44:39ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-02-011310.3389/fimmu.2022.845684845684The Role of the Intestine in the Development of HyperuricemiaHui Yin0Hui Yin1Na Liu2Na Liu3Jie Chen4Jie Chen5Department of Rheumatology and Clinical Immunology, Jiangxi Provincial People’s Hospital, The First Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Rheumatology and Clinical Immunology, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, Nanchang, ChinaDepartment of Rheumatology and Clinical Immunology, Jiangxi Provincial People’s Hospital, The First Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Rheumatology and Clinical Immunology, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, Nanchang, ChinaDepartment of Rheumatology and Clinical Immunology, Jiangxi Provincial People’s Hospital, The First Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Rheumatology and Clinical Immunology, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, Nanchang, ChinaGout is a common inflammatory arthritis caused by the deposition of sodium urate crystals in the joints. Hyperuricemia is the fundamental factor of gout. The onset of hyperuricemia is related to purine metabolism disorders or uric acid excretion disorders. Current studies have shown that the intestine is an important potential organ for the excretion of uric acid outside the kidneys. The excretion of uric acid of gut is mainly achieved through the action of uric acid transporters and the catabolism of intestinal flora, which plays an important role in the body’s uric acid balance. Here we reviewed the effects of intestinal uric acid transporters and intestinal flora on uric acid excretion, and provide new ideas for the treatment of hyperuricemia and gout.https://www.frontiersin.org/articles/10.3389/fimmu.2022.845684/fullgouthyperuricemiaABCG2SLC2A9intestinal flora |
| spellingShingle | Hui Yin Hui Yin Na Liu Na Liu Jie Chen Jie Chen The Role of the Intestine in the Development of Hyperuricemia Frontiers in Immunology gout hyperuricemia ABCG2 SLC2A9 intestinal flora |
| title | The Role of the Intestine in the Development of Hyperuricemia |
| title_full | The Role of the Intestine in the Development of Hyperuricemia |
| title_fullStr | The Role of the Intestine in the Development of Hyperuricemia |
| title_full_unstemmed | The Role of the Intestine in the Development of Hyperuricemia |
| title_short | The Role of the Intestine in the Development of Hyperuricemia |
| title_sort | role of the intestine in the development of hyperuricemia |
| topic | gout hyperuricemia ABCG2 SLC2A9 intestinal flora |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.845684/full |
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