Hepcidin is a useful biomarker to evaluate hyperferritinemia associated with metabolic syndrome
Abstract: Investigation of hyperferritinemia in metabolic syndrome patients represents a diagnostic challenge, but it is essential for the identification of individuals with iron overload. Hepcidin negatively regulates iron absorption and release. An increase in hepcidin occurs when iron levels are...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Ciências
2019-05-01
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| Series: | Anais da Academia Brasileira de Ciências |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300803&lng=en&tlng=en |
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| author | MARIANA R. RAUBER DIOGO A. PILGER DAIANE K. CECCONELLO FREDERICO S. FALCETTA NATÁLIA A. MARCONDES GUSTAVO A.M. FAULHABER |
| author_facet | MARIANA R. RAUBER DIOGO A. PILGER DAIANE K. CECCONELLO FREDERICO S. FALCETTA NATÁLIA A. MARCONDES GUSTAVO A.M. FAULHABER |
| author_sort | MARIANA R. RAUBER |
| collection | DOAJ |
| description | Abstract: Investigation of hyperferritinemia in metabolic syndrome patients represents a diagnostic challenge, but it is essential for the identification of individuals with iron overload. Hepcidin negatively regulates iron absorption and release. An increase in hepcidin occurs when iron levels are sufficient or in inflammatory states, conditions often associated with hyperferritinemia. Hemochromatosis causes hyperferritinemia due to iron overload, but frequently has low hepcidin levels. Our aim was to evaluate biochemical and molecular parameters related to iron metabolism in patients with metabolic syndrome. We evaluated 94 patients with metabolic syndrome according to the International Diabetes Federation criteria in a cross-sectional study. Anthropometric data and diagnostic criteria for metabolic syndrome, iron dosage, ferritin, transferrin saturation, hepcidin, and the C282Y and H63D mutations in the HFE hemochromatosis gene were evaluated. Prevalence of hyperferritinemia in the study population was 27.7% and was higher in males (46.2%) than in females (14.5%). Increase in transferrin saturation correlated with mutations in the hemochromatosis gene. Hyperferritinemia was associated to transferrin saturation and hepcidin after logistic regression analysis. In conclusion, hyperferritinemia is a frequent finding in metabolic syndrome patients, most frequently in men; and hepcidin assessment can be useful for the investigation of ferritin increase in those subjects. |
| first_indexed | 2024-12-21T08:26:14Z |
| format | Article |
| id | doaj.art-61e6f6fef6634afaba11fe7bfcb444b0 |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-12-21T08:26:14Z |
| publishDate | 2019-05-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-61e6f6fef6634afaba11fe7bfcb444b02022-12-21T19:10:19ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902019-05-0191210.1590/0001-3765201920180286S0001-37652019000300803Hepcidin is a useful biomarker to evaluate hyperferritinemia associated with metabolic syndromeMARIANA R. RAUBERDIOGO A. PILGERDAIANE K. CECCONELLOFREDERICO S. FALCETTANATÁLIA A. MARCONDESGUSTAVO A.M. FAULHABERAbstract: Investigation of hyperferritinemia in metabolic syndrome patients represents a diagnostic challenge, but it is essential for the identification of individuals with iron overload. Hepcidin negatively regulates iron absorption and release. An increase in hepcidin occurs when iron levels are sufficient or in inflammatory states, conditions often associated with hyperferritinemia. Hemochromatosis causes hyperferritinemia due to iron overload, but frequently has low hepcidin levels. Our aim was to evaluate biochemical and molecular parameters related to iron metabolism in patients with metabolic syndrome. We evaluated 94 patients with metabolic syndrome according to the International Diabetes Federation criteria in a cross-sectional study. Anthropometric data and diagnostic criteria for metabolic syndrome, iron dosage, ferritin, transferrin saturation, hepcidin, and the C282Y and H63D mutations in the HFE hemochromatosis gene were evaluated. Prevalence of hyperferritinemia in the study population was 27.7% and was higher in males (46.2%) than in females (14.5%). Increase in transferrin saturation correlated with mutations in the hemochromatosis gene. Hyperferritinemia was associated to transferrin saturation and hepcidin after logistic regression analysis. In conclusion, hyperferritinemia is a frequent finding in metabolic syndrome patients, most frequently in men; and hepcidin assessment can be useful for the investigation of ferritin increase in those subjects.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300803&lng=en&tlng=endiagnostic screeningferritinhepcidinironmetabolic syndrome |
| spellingShingle | MARIANA R. RAUBER DIOGO A. PILGER DAIANE K. CECCONELLO FREDERICO S. FALCETTA NATÁLIA A. MARCONDES GUSTAVO A.M. FAULHABER Hepcidin is a useful biomarker to evaluate hyperferritinemia associated with metabolic syndrome Anais da Academia Brasileira de Ciências diagnostic screening ferritin hepcidin iron metabolic syndrome |
| title | Hepcidin is a useful biomarker to evaluate hyperferritinemia associated with metabolic syndrome |
| title_full | Hepcidin is a useful biomarker to evaluate hyperferritinemia associated with metabolic syndrome |
| title_fullStr | Hepcidin is a useful biomarker to evaluate hyperferritinemia associated with metabolic syndrome |
| title_full_unstemmed | Hepcidin is a useful biomarker to evaluate hyperferritinemia associated with metabolic syndrome |
| title_short | Hepcidin is a useful biomarker to evaluate hyperferritinemia associated with metabolic syndrome |
| title_sort | hepcidin is a useful biomarker to evaluate hyperferritinemia associated with metabolic syndrome |
| topic | diagnostic screening ferritin hepcidin iron metabolic syndrome |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300803&lng=en&tlng=en |
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