Development of Mucoadhesive Buccal Film for Rizatriptan: In Vitro and In Vivo Evaluation

Development of Mucoadhesive Buccal Film for Rizatriptan: In Vitro and In Vivo Evaluation

The reduced therapeutic efficacy of rizatriptan in migraine treatment is primarily due to low oral bioavailability and extensive first pass metabolism. The purpose of this investigation was to optimize the thin mucoadhesive buccal film of rizatriptan and assess the practicability of its development...

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Bibliographic Details
Main Authors: Anroop B. Nair, Jigar Shah, Shery Jacob, Bandar E. Al-Dhubiab, Vimal Patel, Nagaraja Sreeharsha, Pottathil Shinu
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
migraine
Proloc
Eudragit
physicomechanical
release
in vivo
Online Access:https://www.mdpi.com/1999-4923/13/5/728

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