The Role of NRF2 in Mycobacterial Infection
The incidence of pulmonary nontuberculous mycobacterial (NTM) infection is increasing worldwide, and its clinical outcomes with current chemotherapies are unsatisfactory. The incidence of tuberculosis (TB) is still high in Africa, and the existence of drug-resistant tuberculosis is also an important...
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/12/1861 |
| _version_ | 1827674376161460224 |
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| author | Masashi Matsuyama Mizu Nonaka Masayuki Nakajima Yuko Morishima Yukio Ishii Nobuyuki Hizawa |
| author_facet | Masashi Matsuyama Mizu Nonaka Masayuki Nakajima Yuko Morishima Yukio Ishii Nobuyuki Hizawa |
| author_sort | Masashi Matsuyama |
| collection | DOAJ |
| description | The incidence of pulmonary nontuberculous mycobacterial (NTM) infection is increasing worldwide, and its clinical outcomes with current chemotherapies are unsatisfactory. The incidence of tuberculosis (TB) is still high in Africa, and the existence of drug-resistant tuberculosis is also an important issue for treatment. To discover and develop new efficacious anti-mycobacterial treatments, it is important to understand the host-defense mechanisms against mycobacterial infection. Nuclear erythroid 2 p45-related factor-2 (NRF2) is known to be a major regulator of various antioxidant response element (ARE)-driven cytoprotective gene expressions, and its protective role has been demonstrated in infections. However, there are not many papers or reviews regarding the role of NRF2 in mycobacterial infectious disease. Therefore, this review focuses on the role of NRF2 in the pathogenesis of <i>Mycobacterium tuberculosis</i> and <i>Mycobacterium avium</i> infection. |
| first_indexed | 2024-03-10T04:38:33Z |
| format | Article |
| id | doaj.art-61e7ce581c6b4528bb491b1d34f1228c |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T04:38:33Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-61e7ce581c6b4528bb491b1d34f1228c2023-11-23T03:32:04ZengMDPI AGAntioxidants2076-39212021-11-011012186110.3390/antiox10121861The Role of NRF2 in Mycobacterial InfectionMasashi Matsuyama0Mizu Nonaka1Masayuki Nakajima2Yuko Morishima3Yukio Ishii4Nobuyuki Hizawa5Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Ibaraki, JapanDepartment of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Ibaraki, JapanDepartment of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Ibaraki, JapanDepartment of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Ibaraki, JapanDepartment of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Ibaraki, JapanDepartment of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Ibaraki, JapanThe incidence of pulmonary nontuberculous mycobacterial (NTM) infection is increasing worldwide, and its clinical outcomes with current chemotherapies are unsatisfactory. The incidence of tuberculosis (TB) is still high in Africa, and the existence of drug-resistant tuberculosis is also an important issue for treatment. To discover and develop new efficacious anti-mycobacterial treatments, it is important to understand the host-defense mechanisms against mycobacterial infection. Nuclear erythroid 2 p45-related factor-2 (NRF2) is known to be a major regulator of various antioxidant response element (ARE)-driven cytoprotective gene expressions, and its protective role has been demonstrated in infections. However, there are not many papers or reviews regarding the role of NRF2 in mycobacterial infectious disease. Therefore, this review focuses on the role of NRF2 in the pathogenesis of <i>Mycobacterium tuberculosis</i> and <i>Mycobacterium avium</i> infection.https://www.mdpi.com/2076-3921/10/12/1861ROSNRF2ARETBNTMIFN-γ |
| spellingShingle | Masashi Matsuyama Mizu Nonaka Masayuki Nakajima Yuko Morishima Yukio Ishii Nobuyuki Hizawa The Role of NRF2 in Mycobacterial Infection Antioxidants ROS NRF2 ARE TB NTM IFN-γ |
| title | The Role of NRF2 in Mycobacterial Infection |
| title_full | The Role of NRF2 in Mycobacterial Infection |
| title_fullStr | The Role of NRF2 in Mycobacterial Infection |
| title_full_unstemmed | The Role of NRF2 in Mycobacterial Infection |
| title_short | The Role of NRF2 in Mycobacterial Infection |
| title_sort | role of nrf2 in mycobacterial infection |
| topic | ROS NRF2 ARE TB NTM IFN-γ |
| url | https://www.mdpi.com/2076-3921/10/12/1861 |
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