DrugSniper, a Tool to Exploit Loss-Of-Function Screens, Identifies <i>CREBBP</i> as a Predictive Biomarker of VOLASERTIB in Small Cell Lung Carcinoma (SCLC)

DrugSniper, a Tool to Exploit Loss-Of-Function Screens, Identifies <i>CREBBP</i> as a Predictive Biomarker of VOLASERTIB in Small Cell Lung Carcinoma (SCLC)

The development of predictive biomarkers of response to targeted therapies is an unmet clinical need for many antitumoral agents. Recent genome-wide loss-of-function screens, such as RNA interference (RNAi) and CRISPR-Cas9 libraries, are an unprecedented resource to identify novel drug targets, repo...

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Bibliographic Details
Main Authors: Fernando Carazo, Cristina Bértolo, Carlos Castilla, Xabier Cendoya, Lucía Campuzano, Diego Serrano, Marian Gimeno, Francisco J. Planes, Ruben Pio, Luis M. Montuenga, Angel Rubio
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
biomarker
small cell lung carcinoma
SCLC
CREBBP
PLK1
gene essentiality
Online Access:https://www.mdpi.com/2072-6694/12/7/1824

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