Ambient particulate matter, maternal thyroid function, and birth weight: A mediation analysis
Background: Birth weight (BW) is an indicator of fetal growth and development. Previous studies showed inconsistent results on the association of ambient particulate matter (PM) exposure with BW, and the role of maternal thyroid function has not been clarified. Methods: We recruited 1711 gravidas be...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323009247 |
| _version_ | 1797676680559460352 |
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| author | Yuting Gong Yueshu Zhao Xiaoan Zhang Xin Zhao Hui Chang Jia Huang Zengli Yu Huanhuan Zhang Hongyan Liu |
| author_facet | Yuting Gong Yueshu Zhao Xiaoan Zhang Xin Zhao Hui Chang Jia Huang Zengli Yu Huanhuan Zhang Hongyan Liu |
| author_sort | Yuting Gong |
| collection | DOAJ |
| description | Background: Birth weight (BW) is an indicator of fetal growth and development. Previous studies showed inconsistent results on the association of ambient particulate matter (PM) exposure with BW, and the role of maternal thyroid function has not been clarified. Methods: We recruited 1711 gravidas between 2017 and 2019 in Henan, China. All participants were followed up until delivery. Daily concentrations of PM, including PM2.5 and PM10, were evaluated by using the spatial-temporal model. Maternal thyroid hormone (TH) levels were quantified by electrochemiluminescent microparticle immunoassay. Linear regression models were employed to examine the association among PM, BW, and maternal TH. Mediating effects of maternal TH interrelated with PM exposure on BW were investigated by causal mediation analyses. Results: A total of 1049 gravidas were identified. We found that per 10 µg/m3 increase in PM2.5 and PM10 were associated with a decreased BW of 9.941 g, and 7.758 g (PM2.5: 95 %CI: −18.184, −1.698; PM10: 95 %CI: −14.436, −1.080). An inverse correlation of maternal FT4 levels with BW was found, with the pooled β of −319.983 g (95 %CI: −483.216, −156.750). We found a prominent positive correlation between gestational FT4 and PM exposure (PM2.5: β = 0.004, 95 %CI: 0.001, 0.007; PM10: β = 0.003, 95 %CI: 0.000, 0.006). Mediation analysis found that FT4 levels mediated the relationship between maternal PM exposure and BW, ranging from 5.55 % to 15.86 %. Conclusions: Maternal PM exposure may induce a reduction in newborn BW by affecting the maternal TH concentrations. |
| first_indexed | 2024-03-11T22:31:49Z |
| format | Article |
| id | doaj.art-61e857bcaee04b79b05f066610cd223b |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-03-11T22:31:49Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-61e857bcaee04b79b05f066610cd223b2023-09-23T05:09:57ZengElsevierEcotoxicology and Environmental Safety0147-65132023-10-01264115420Ambient particulate matter, maternal thyroid function, and birth weight: A mediation analysisYuting Gong0Yueshu Zhao1Xiaoan Zhang2Xin Zhao3Hui Chang4Jia Huang5Zengli Yu6Huanhuan Zhang7Hongyan Liu8Department of Medical Genetics, Henan Provincial People’s Hospital; People’s Hospital of Zhengzhou University, Zhengzhou, China; School of Public Health, Zhengzhou University, Zhengzhou, ChinaThe Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaThe Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaThe Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaThe Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Medical Genetics, Henan Provincial People’s Hospital; People’s Hospital of Zhengzhou University, Zhengzhou, ChinaSchool of Public Health, Zhengzhou University, Zhengzhou, ChinaSchool of Public Health, Zhengzhou University, Zhengzhou, China; Corresponding author.Department of Medical Genetics, Henan Provincial People’s Hospital; People’s Hospital of Zhengzhou University, Zhengzhou, China; Correspondence to: Department of Medical Genetics, Henan Provincial People’s Hospital Affiliated Zhengzhou University, Zhengzhou, China.Background: Birth weight (BW) is an indicator of fetal growth and development. Previous studies showed inconsistent results on the association of ambient particulate matter (PM) exposure with BW, and the role of maternal thyroid function has not been clarified. Methods: We recruited 1711 gravidas between 2017 and 2019 in Henan, China. All participants were followed up until delivery. Daily concentrations of PM, including PM2.5 and PM10, were evaluated by using the spatial-temporal model. Maternal thyroid hormone (TH) levels were quantified by electrochemiluminescent microparticle immunoassay. Linear regression models were employed to examine the association among PM, BW, and maternal TH. Mediating effects of maternal TH interrelated with PM exposure on BW were investigated by causal mediation analyses. Results: A total of 1049 gravidas were identified. We found that per 10 µg/m3 increase in PM2.5 and PM10 were associated with a decreased BW of 9.941 g, and 7.758 g (PM2.5: 95 %CI: −18.184, −1.698; PM10: 95 %CI: −14.436, −1.080). An inverse correlation of maternal FT4 levels with BW was found, with the pooled β of −319.983 g (95 %CI: −483.216, −156.750). We found a prominent positive correlation between gestational FT4 and PM exposure (PM2.5: β = 0.004, 95 %CI: 0.001, 0.007; PM10: β = 0.003, 95 %CI: 0.000, 0.006). Mediation analysis found that FT4 levels mediated the relationship between maternal PM exposure and BW, ranging from 5.55 % to 15.86 %. Conclusions: Maternal PM exposure may induce a reduction in newborn BW by affecting the maternal TH concentrations.http://www.sciencedirect.com/science/article/pii/S0147651323009247Particulate matterThyroid functionBirth weightMediation analysis |
| spellingShingle | Yuting Gong Yueshu Zhao Xiaoan Zhang Xin Zhao Hui Chang Jia Huang Zengli Yu Huanhuan Zhang Hongyan Liu Ambient particulate matter, maternal thyroid function, and birth weight: A mediation analysis Ecotoxicology and Environmental Safety Particulate matter Thyroid function Birth weight Mediation analysis |
| title | Ambient particulate matter, maternal thyroid function, and birth weight: A mediation analysis |
| title_full | Ambient particulate matter, maternal thyroid function, and birth weight: A mediation analysis |
| title_fullStr | Ambient particulate matter, maternal thyroid function, and birth weight: A mediation analysis |
| title_full_unstemmed | Ambient particulate matter, maternal thyroid function, and birth weight: A mediation analysis |
| title_short | Ambient particulate matter, maternal thyroid function, and birth weight: A mediation analysis |
| title_sort | ambient particulate matter maternal thyroid function and birth weight a mediation analysis |
| topic | Particulate matter Thyroid function Birth weight Mediation analysis |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323009247 |
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