Solid dispersion-based pellet for colon delivery of tacrolimus through time- and pH-dependent layer coating: preparation, in vitro and in vivo studies

Solid dispersion-based pellet for colon delivery of tacrolimus through time- and pH-dependent layer coating: preparation, in vitro and in vivo studies

The intent of the present investigation is to develop and evaluate colon-specific coated tacrolimus solid dispersion pellet (SDP) that retards drug release in the stomach and small intestine but progressively releases in the colon. Tacrolimus-SDP was prepared by extrusion-spheronization technology a...

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Bibliographic Details
Main Authors: Jian Guo, Huihui Fang, Shuangying Gui, Yuzhe Huang
Format: Article
Language:English
Published: Universidade de São Paulo 2019-10-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Tacrolimus
Solid dispersion
Pellet
Oral colon-specific
Biodistribution
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100557&tlng=en

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